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Therapy of diffuse aggressive lymphomas

  • Yener Koc
  • David P. Schenkein
Part of the Cancer Treatment and Research book series (CTAR, volume 99)

Abstract

The non-Hodgkin’s lymphomas (NHLs) represent a heterogeneous group of disorders linked together by the commonality of a malignant monoclonal population of either B or T lymphocytes but differing in clinical presentation, prognosis, and treatment strategies. In 1997, the estimated number of new cases of NHL was 53,600, with a slight preponderance toward males (M/F ratio: 1.3)[1]. The estimated number of deaths secondary to NHL was 23,800 (44.4%) in the same year. Non-Hodgkin’s lymphoma is among the top 10 leading cancers in females and males, constituting 4% of newly diagnosed cancers in both sexes[1]. Among the reported deaths due to cancer in the United States, NHL is the second most frequent cause in males in the 15-34 age group and the third most frequent cause in the 35-54 age group[1]. The most common aggressive lymphoma is diffuse large B-cell lymphoma, accounting for 60%-70% of cases in the United States and Europe. The focus of this chapter will be the review of the treatment approaches for aggressive lymphomas as defined by both the Working Formulation (WF) and the Revised European-American Lymphoma (REAL) classification systems[2]. Treatment for the follicular lymphomas will be covered elsewhere.

Keywords

Complete Remission Clin Oncol International Prognostic Index Anaplastic Large Cell Lymphoma Complete Remission Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Yener Koc
  • David P. Schenkein

There are no affiliations available

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