Advances in the therapy of the myelodysplastic syndromes

  • Peter A. Kouides
  • John M. Bennett
Part of the Cancer Treatment and Research book series (CTAR, volume 99)


The myelodysplastic syndrome (MDS) has been a most challenging disease for hematologists for decades. In terms of diagnosis, it was less than 20 years ago that the French-American-British (FAB) group developed criteria for the diagnosis and the classification of the myelodysplastic syndromes [1]. The FAB classification has provided a common language for hematologists, morphologists, and pathologists in the investigation of this clonal bone marrow disease, since, studies could be compared in part by stratifying patients into the appropriate MDS subgroup. Since its development, the FAB classification has led to countless studies — from kinder, gentler approaches using various vitamins in hopes of inducing differentiation of the MDS clone to ‘brute force’ approaches of high-dose therapy with allogeneic marrow rescue. This chapter will review therapeutic studies published in the past four years; readers interested in details of earlier studies can consult several references [2,3].


Acute Myeloid Leukemia Clin Oncol Myelodysplastic Syndrome Acute Myelogenous Leukemia Stem Cell Factor 


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Copyright information

© Kluwer Academic Publishers, Boston 1999

Authors and Affiliations

  • Peter A. Kouides
  • John M. Bennett

There are no affiliations available

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