Models for mechanical loading of hone and hone cells in vivo and in vitro

  • Timothy M. Skerry


While the skeleton has many functions, the one that governs the shape and mass of each bone is the requirement to resist the effects of mechanical forces. When this requirement is not met, bones break. Since the disability associated with a broken bone affects the survival of an individual and therefore the species, there has been an evolutionary drive to minimize fracture incidence. Against this are the needs of efficiency, since an overengineered skeleton is excessively heavy to grow, maintain and use. The end result of these opposing requirements is that in each individual the mass of bone is adapted to habitual activity so that most normal and even abnormal loading incidents will not cause fracture.


Bone Formation Bone Loss Bone Mass Mechanical Loading Bone Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Chapman and Hall Ltd 1998

Authors and Affiliations

  • Timothy M. Skerry

There are no affiliations available

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