Animal models for the investigation of the action of factors on bone metabolism

  • Colin R. Dunstan
  • Brendan F. Boyce


There is increasing interest from the world’s pharmaceutical industry in the problems of bone pathology, and many of the large companies and many smaller biotechnology companies have active bone research programmes. This chapter has been structured to encompass the requirements for both investigational (i.e. research) and preclinical assessment of factors with putative action (therapeutic or otherwise) on bone resorption or formation associated with bone modelling and remodelling. Models of fracture and repair of segmental defects are beyond the scope of this chapter. Investigational requirements centre around identification of an activity or validation of an activity identified in in vitro systems. Preclinical assessment centres around application of an activity to human disease. Under normal circumstances there is a progression from the investigational studies into preclinical assessment.


Bone Loss Bone Resorption Cancellous Bone Growth Plate Cynomolgus Monkey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Chapman and Hall Ltd 1998

Authors and Affiliations

  • Colin R. Dunstan
  • Brendan F. Boyce

There are no affiliations available

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