Apoptosis in Normal and Pathological Vessels

  • Ziad Mallat
  • Alain Tedgui
Part of the Basic Science for the Cardiologist book series (BASC, volume 1)


Vascular pathologists have long been intrigued by the observation of a form of active vascular cell death within the arterial wall in atherosclerosis [1, 2] or during normal aging [3] in the absence of overt necrosis. Rational explanations for these observations may now be at hand after the description by Kerr and colleagues in the early 1970s of a novel form of cell death distinct from necrosis, which they designated “apoptosis” (from the Greek word for falling) [4]. It has since been increasingly recognized that apoptosis may be involved in a number of critical events occurring during normal development and may play a key role in a wide variety of diseases [5].


Vascular Endothelial Growth Factor Vascular Smooth Muscle Cell Atherosclerotic Plaque Human Endothelial Cell Arterioscler Thromb Vasc Biol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Ziad Mallat
    • 1
  • Alain Tedgui
    • 1
  1. 1.Lariboisière HospitalInserm U141ParisFrance

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