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Male Puberty and Its Disorders

  • Chapter
Male Reproductive Function

Part of the book series: Mineralogical Society Series ((ENDO,volume 5))

Abstract

This chapter selectively highlights the major advances in the past three years. Consideration is given to those areas which have made a significant impact on our understanding of the mechanisms of pubertal regulation and influenced clinical management of male pubertal disorders. For a more comprehensive general coverage of this topic, the reader should refer to other recent reviews and monographs (Plant, 1994; Plant, 1995; Grumbach and Styne, 1998).

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References

  • Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates onset of puberty in normal female mice. J Clin Invest 1997;99:391–5.

    PubMed  CAS  Google Scholar 

  • Aittomaki K, Dieguez L, Lucena JL, Pakarinen P, Sistonen P, Tapanainen J, Gromoll J, Kaskikari R, Sankila EM, Lehvaslaiho H, Engel AR. Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic hypogonadism. Cell 1995;82:959–968.

    PubMed  CAS  Google Scholar 

  • Aittomaki K, Herva R, Stenman UH, Juntunen K, Ylostalo P, Hovatta O, de la Chapelle A. Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene. J Clin Endocrinol Metab 1996;81:3722–6.

    PubMed  CAS  Google Scholar 

  • Albanese C, Colin IM, Crowley WF, Ito M, Pestell RG, Weiss J, Jameson JL. The gonadotrpin genes: evolution of distinct mechanisms for hormone control. Rec Progr Horm Res 1996;51:23–58.

    PubMed  CAS  Google Scholar 

  • Albanese A, Kewley GD, Long A, Pearl KN, Robins DG, Stanhope R. Oral treatment for consitutional delay of growth and puberty in boys: a randomised trial of an anabolic steroid or testosterone undecanoate. Arch Dis Child 1994;71:315–7.

    PubMed  CAS  Google Scholar 

  • Albertsson-Wikland K, Rosberg S, Lannering B, Dunkel L, Selstam G, Norjavaara E. Twenty-four hour profiles of luteinizing hormone, follicle stimulating hormone, testosterone, and estradiol levels: a semilongitudinal study throughout puberty in healthy boys. J Clin Endocrinol Metab 1997;82:541–549.

    PubMed  CAS  Google Scholar 

  • Andersson AM, Juul A, Petersen JH, Muller J, Groome NP, Skakkebaek NE. Serum inhibin B in healthy pubertal and adolescent boys: relation to age, stage of puberty and FSH, Lh, tstosterone and estradiol levels. J Clin Endocrinol Metab 1997;82:3976–81.

    PubMed  CAS  Google Scholar 

  • Apter D, B, Cacciatore B, Alfthan H, Stenman U-H. Serum luteinizing hormone concentrations increase 100 fold in females from 7 years of age to adulthood as measured by time-resolved immunofluoremetric assay. J Clin Endocrinol and Metab 1989;68: 53–57.

    CAS  Google Scholar 

  • Attie KM, Ramirez NR, Conte FA, et al. The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency:evidence for a direct role of sex steroids. J Clin Endocrinol Metab 1990;71:975–83.

    PubMed  CAS  Google Scholar 

  • Auwerx J, Staels B. Leptin. Lancet1998;351:737–42.

    PubMed  CAS  Google Scholar 

  • Aynsley-Green A, Zachman M, Prader A. Interrelations of the therapeutic effects of growth hormoen and testosterone on growth in hypotuitarism. J Pediatr 1976;89:992–9.

    PubMed  CAS  Google Scholar 

  • Bacharach BE, Smith EP. The role of sex steroids in bone growth and development: evolving new concepts. Endocrinologist 1996;6:362–8.

    Google Scholar 

  • Ballabio A, Zoghbi HY. “Kallmann’s syndrome” In The Metabolic and Molecular Basis of Inherited Diseases. 7yh Edn. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle eds. New York: McGraw-Hill, 1995.pp4549–57.

    Google Scholar 

  • Bassi F, Neri AS, Gheri RG, et al. Oxandrolone in consitutional delay of growth: analysis of the growht patterns up to final stature. J Endocrinol Invest 1993; 16:133–7.

    PubMed  CAS  Google Scholar 

  • Bauman A. Markedly delayed puberty or Kallmann’s syndrome variant. J Androl 1986;7:224–7.

    PubMed  CAS  Google Scholar 

  • Blum F, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy childrren and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904–10.

    PubMed  CAS  Google Scholar 

  • Boepple PA, Mansfield MJ, Wierman ME, et al. Use of a potent, long-acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Endocr Rev 1986;7:24–33.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Franchimont P. Puberty-related increase in episodic LHRH release from rat hypothalamus in vitro. Endocrinology 1984; 114:1941–3.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Gerard A, Alverez Gonazalez ML, Ournelle G, Franchimont P. Endogenous glutamate involvement in pulsatile secretion of Gonadotropin-releasing hormone: evidence from glutamate effect and developmental changes. Endocrinology 1995;136:911–6.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Gerard A, Mathieu J, Mathieu A, Franchimont P. Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty:I. Increased activation of N-methyl-D-aspartate receptors. Endocrinology 1990; 127:873–81.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Gerard A, Purnelle G et al. Dulaity of glutaminergic and Gabaergic control of pulsatile GnRH secretion by rate hypothalamic explants:I. Eeffects of antisense oligonucleotides using expiants including or excluding the preoptic area. J Neuroendocrinol 1997;9:183–91.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Gerard A, Purnelle G et al. Dulaity of glutaminergic and Gabaergic control of pulsatile GnRH secretion by rate hypothalamic explants:II. Reduced NR2C-and GABAA-receptor-mediated inhibition at initiation of sexual maturation. J Neuroendocrinol 1997;9:193–9.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP, Jaeken J, Gerard, A, deZegher F. Amino acid neurotransmission and initiation of puberty: Evidence from nonketotic hyperglycinemia in a female infant and gonadotropin-releasing hormone secretion by rat hypothalamic explants. J Clin Endocrinol Metab 1997; 82:1899–1903.

    PubMed  CAS  Google Scholar 

  • Bourguignon JP. Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr Rev 1988;9:467–88.

    PubMed  CAS  Google Scholar 

  • Bourguinon JP, Gerard A, Mathieu J, Mathieu A, Franchimont P. Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at the onset of puberty: I. Increased activation of N-methyl-D-aspartate receptors. Endocrinology 1990;127:873–881.

    Google Scholar 

  • Brann DW, Mahesh VB. Excitatory amino acids: evidence for a role in the control of reproduction and antrior pituitary hormone secretion. Endocr Rev 1997; 18:678–700

    PubMed  CAS  Google Scholar 

  • Brezezinski A. Melatonin in humans. N Eng J Med 1997; 336:186–95.

    CAS  Google Scholar 

  • Bronson FH. Mammalian reproduction: an ecological perspective. Biol Reprod1985;32:1–26.

    PubMed  CAS  Google Scholar 

  • Bronson FH. The biology of puberty. Biol Rev 1986;61:157–95.

    PubMed  CAS  Google Scholar 

  • Brown DC, Butler GE, Kelnar CJH, Wu, FCW. A double blind placebo controlled study of the effects of low dose testosterone undecanoate on the growth of small for age, prepubertal boys. Arch Dis Child 1995;73:131–5.

    PubMed  CAS  Google Scholar 

  • Brown DC, Stirling HF, Butler GE, Kelnar CJH, Wu FCW. Use of the ultrasensitive time-resolved immunofluorometric assay of LH in the differential diagnosis of normal male prepuberty and hypogonadotrophic hypogonadism. Horm Res 1996; 46:83–87.

    PubMed  CAS  Google Scholar 

  • Buchanan C, Mahesh V, Zamorano P, Brann D. Central nervous system effects of leptin. Trends Endocrinol Metab 1998;9:146–50

    CAS  Google Scholar 

  • Bulun SE. Aromatase deficiency in women and men: would you have predicted the phenotypes? J Clin Endocrinol Metab 1996;81:867–71.

    PubMed  CAS  Google Scholar 

  • Burris TP, Guo W, McCabe ERB. The gene responsible for linked adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily. Rec Progr Horm Res 1996;51:241–59.

    PubMed  CAS  Google Scholar 

  • Burris TP, Guo WW, Le T, McCabe ERB. Identification of a putative steroidogenic factor-1 response element in the DAX-1 promotor. Biochem Biophy Res Comm 1995; 214:576–81.

    CAS  Google Scholar 

  • Butler, G.E., Walker, R.F., Kelnar C.J.H. and Wu, F.C.W. Oral testosterone undecanoate in puberty: pharmcodynamics and effects on growth and sexual maturation. Journal of Clinical Endocrinology and Metabolism, 75, 37–44, 1992.

    PubMed  CAS  Google Scholar 

  • Cacciari E, Frejaville E, Cicognani A, et al. How many cases of true precocious puberty in girls are idiopathic? J Pediatr 1983;102:357–60.

    PubMed  CAS  Google Scholar 

  • Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546–9.

    PubMed  CAS  Google Scholar 

  • Carani C, Kenan Q, Simoni M, et al. Effect of testosterone and estradiol in a man with aromatase deficiency. N Eng J Med 1997;337:91–5.

    CAS  Google Scholar 

  • Caraty A, Locatelli A, Moenter SM, Karsch FJ. “Sampling of hypophyseal portal blood of conscious sheep for direct monitoring of hypothalamic neurosecretory substances” In Pulsatility in Neuroendocrine Systems, J.E. Levine P.M. Conn, eds. New York: Academic Press 1994;pp 162–83.

    Google Scholar 

  • Caraty A, Locatelli A. 1988 Effect of time after castration on secretion of LHRH and LH in the ram. J Reprod Fertil 82: 263–69.

    PubMed  CAS  Google Scholar 

  • Cavallo A, Ritschel WA. Pharmacokinetics of melatonin in human sexual maturation. J Clin Endocrinol Metab 1996;81:1882–6.

    PubMed  CAS  Google Scholar 

  • Cavallo A. Melatonin and human puberty: current perspectives. J Pineal Res 1993: 15:115–121.

    PubMed  CAS  Google Scholar 

  • Chan SM, Cutler GB. Molecular aspects of precocious puberty. Adv Mol Cell Endocrinol 1998;2:121–41.

    CAS  Google Scholar 

  • Chehab FF, Mounzih K, Lu R, Lim MF. Early onset of reproductive function in normal female mice treated with leptin. Science 1997;275:88–90.

    PubMed  CAS  Google Scholar 

  • Cheung CC, Thornton JE, Kuijper JL, et al. Leptin is a meetabolic gate for the onset of puberty in the female rat. Endocrinology 1997; 138:855–8.

    PubMed  CAS  Google Scholar 

  • Chongthammankun S, Claypool LE, Terasawa E. Ovariectomy increases in vivo luteinizing hormone releasing hormone releases in pubertal, but not prepibertal, female rhesus monkeys. J Neuroendocrinol 1993:5:41–50.

    Google Scholar 

  • Chongthammankun S, Terasawa E. Negative feedback effects of estrogen on luteinizing hormone releasing hormone release occur in pubertal, but not prepubertal, ovareictomized female rhesus monkeys. Endocrinology 1993; 132:735–43.

    Google Scholar 

  • Clark PA, Iranmanesh A, Veldhuis JD, Rogol AD. Comparison of pulsatile luteinizing hormone secretion between prepubertal children and young adults: evidence for a mass/amplitude-dependent difference without gender or day/night contrasts. J Clin Endocrinol Metab 1997;82:2950–55.

    PubMed  CAS  Google Scholar 

  • Clarke IJ, Cummins JT. 1982 The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomised ewes. Endocrinology 111: 1737–39.

    PubMed  CAS  Google Scholar 

  • Clayton PE, Gill MS, Hall CM, et al. Serum leptin through childhood and adolescence. Clin Endocrinol 1997;46:727–33.

    CAS  Google Scholar 

  • Conn PM, Crowley WF. Gonadotrpin-releasing hormone and its analogs. Ann Rev Med 1994;45:391–405.

    PubMed  CAS  Google Scholar 

  • Conn PM, Janovick JA, Stanislaus D, Kuphal, Jennes L. Molecular and cellular bases of gonaodotropin-releasing hormone action in the pituitary and central nervous system. Vit Horm 1995;50:151–214.

    CAS  Google Scholar 

  • Considine RV, Sinha MK, Heiman ML, et al. Serum immunoactive-leptin concentrations in norma-weight and obese humans. N Eng J Med 1996;334:292–5.

    CAS  Google Scholar 

  • Crawford PA, Dorn C, Sadovsky Y, Milbrandt J. Nuclear receptor DAX-1 recriots nuclear receptor corepressor N-cor to steroidogenic factor 1. Mol Cell Biol 1998;18:2949–56.

    PubMed  CAS  Google Scholar 

  • Crofton PM, Illingworth PJ, Groome NP, et al. Changes in dimeric inhibin A and B during normal early puberty in boys and girls. Clin Endocrinol 1997;46: 109–114.

    CAS  Google Scholar 

  • Crowley Jr WF, Comite F, Vale WA, et al. Therapeutic use of pituitary-desensitization with a long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab 1981;52:370–2.

    PubMed  Google Scholar 

  • Cutler GB Jr. “Overview of premature sexual development” In Sexual Precocity: Etiology, Diagnosis and Management, G.D. Grave, G.B. Cutler Jr eds. New York: Raven Press 1993;pp1–10.

    Google Scholar 

  • Cutler GB. The role of estrogen in bone growth and maturation during childhood. J Steroid Biochem Molec 1997;61:141–4

    CAS  Google Scholar 

  • Danon MS, Robboy SH, Kin S, et al. Cushing syndrome, sexual precocity, and polyostotoc fibrous dysplasia. J Pediatr 1975;87:917–21.

    PubMed  CAS  Google Scholar 

  • de Roux N, Misrahi M, Young J, et al. Genetic abnormalities and expression in disease of GnRHand gonadotropin receptors. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27;S45–3.

    Google Scholar 

  • de Roux N, Young J, Misrahi M, et al. A family with hypogonaotropic hypogonaidsm and mutations in the gonadotropin-releasing hormone receptor. N Eng J Med 1997;337:1597–16–2.

    Google Scholar 

  • Dufau ML. The luteinizinh hormone receptor. Curr Opinion Endocr Diabestes 1995;2:365–74.

    CAS  Google Scholar 

  • Dunkel L, Alfthan H, Stenman U-H et al. Developmental changes in 24-hour profiles of luteinizing hormone and follicle stimulating hormone from prepuberty to midstages of puberty in boys. J Clin Endocrinol Metab 1992;74:890–7.

    PubMed  CAS  Google Scholar 

  • Dunkel L, Alfthan H, Stenman U-H, Perheentupa J. Gonadal control of pulsatile secretion of luteinizing hormone and follicle-stimulating hormone evaluated by ultrasensitive time-resolved immunofluorometric assays. J Clin Endocrinol and Metab 1990;70: 107–114.

    CAS  Google Scholar 

  • Dunkel L, Alfthan H, Stenman U-H, Perheentupa. Gonadal control of pulsatile secretion of luteinizing hormone and follicle stimulating hormone in prepubertal boys evaluated by ultrasensitive time-resolved immunofluorometric assays. J Clin Endocrinol Metab 1990;70:107–114.

    PubMed  CAS  Google Scholar 

  • Ehrmann D, Rosenfield RL, Cuttler L, Burstein S, Cara JF, Levitsky L. A new test of combined pituitary testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty: Pilot studies. J Clin Endocrinol Metab 1989;69:963–8.

    PubMed  CAS  Google Scholar 

  • Erickson JC, Ahima R, Hallopeter G, Flier JS, Palmiter RD. Endocrine function of the nueuropeptide Y knoutont mice. Regul Pept 1997;70:199–202.

    PubMed  CAS  Google Scholar 

  • Eyigor O, Jennes L. Expression of glutamate receptor subunit mRNA in gonadotrpin-releasing hormone neuron during the sexual maturation of the female rat. Neuroendocrinol 1997; 66:122–9.

    CAS  Google Scholar 

  • Filicori M, Flamigni C, Crowley Jr WF. The critical role of blood sampling frequency in the estimation of episodic luteinizing hormone secretion in normal women. In The Episodic Secretion of Hormones. WF Crowley Jr, Hofler JG eds. New York: Churchill Livingstone, 1989 pp5–13.

    Google Scholar 

  • Finkelstein JS, Klibanski A, Neer RM. A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty. J Clin Endocrinol Metab 1996;81:1152–5.

    PubMed  CAS  Google Scholar 

  • Finkelstein JS, Neer RM, Biller BMK, Crawford JD, Klibanski A. Osteopenia in adult men with histories of delayed puberty. N Eng J Med 1992;326:600–4.

    CAS  Google Scholar 

  • Flier JS. What’s in a name? In search of leptin’s physiological role. J Clin Endocrinol Metab 1998;88:1407–13.

    Google Scholar 

  • Fraioli F, Cappa M, Fabbri A et al. Lack of endogenous opioid inhibitory tone on LH secretion in eraly puberty. Clin Endocrinol 1984;20:299–305.

    CAS  Google Scholar 

  • Frisch RE, McArthur JW. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for thier maintenance or onset. Science 1974; 185:949–51.

    PubMed  CAS  Google Scholar 

  • Frisch RE. Critical fat hypothesis. Am J Physiol 1997;273:E231–2

    PubMed  CAS  Google Scholar 

  • Garcia-Mayor RV, Andrade A, Rios M, et al. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 1997;82:2849–55.

    PubMed  CAS  Google Scholar 

  • Georgopoulos NA, Pralong FP, Seidman CE, et al. Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency. J Clin Endocrinol Metab 1997;82:213–7.

    PubMed  CAS  Google Scholar 

  • Ghai K, Cara JF, Rosenfield RL. Gonadotropin-releasing hormone agonist (Nafarelin) test to differentiatae gonadotropin deficiency from contitutional delayead puberty in teenage boys-A clinical research centre study. J Clin Endocrinol Metab 1995;80:2980–6.

    PubMed  CAS  Google Scholar 

  • Giovanelli G, Bernacomi S, Banchini G. McCune-Albright syndrome in a male child: a clinical and endocrinological enigma. J Pediatr 1978;92:220–6.

    Google Scholar 

  • Goji K, Tanikaze S. Spontaenous gonadotrpin and testosterone concentration profiles in prepubertal and pubertal boys: temporal relationship between luteinizing hormone and testosterone. Pediatr Res 1993;34:229–36.

    PubMed  CAS  Google Scholar 

  • Goldsmith PC, Lamberts R, Jao YC. “Gonadotropin-releasing neurons and pathways in primate hypothalamus and forebrain” In Neuroendocrine Aspects of Reproduction. New york: Raven Press, pp27–45. 1983

    Google Scholar 

  • Gruaz NM, Lalaoui M, Pierroz DD, et al. Failure of leptin administration to advance sexual maturation in the female rat. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27; P3–668.

    Google Scholar 

  • Grumbach MM & Styne DM. “Puberty: ontogeny, neuroendocrinology, physiology, and disorders” In Williams Textbook of Endocrinology, 9th Edition J.D. Wilson, D.W. Foster eds. Philadelphia: W.B. Saunders & Co. 1998, pp 1509–1625.

    Google Scholar 

  • Guo W, Burris TP, Zhang YH, et al. Genomic sequence of the DAX-1 gene: an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypoggonadotropic hypogonadism. J Clin Endocrinol Metab 1995;81:2481–6.

    Google Scholar 

  • Guo W, Mason JS, Stone CG, et al. Diagnosis of X-linked linked adrenal hypoplasia congenita by mutation analysiis of the DAX-1 gene. JAMA 1995; 274:324–30.

    PubMed  CAS  Google Scholar 

  • Haavisto A-M, Pettersson K, Bergendahl M, Virkmaki A, Huhtaniemi I. Occurrence and biological properties of a common genetic variant of luteinizing hormone. J Clin Endocrinol Metab 1995;80:1257–63.

    PubMed  CAS  Google Scholar 

  • Habiby RL, Boepple P, Nachtigall. Et al. Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalamic and pituitary defects in gonadotropin production. J Clin Invest 1996;98:1055–62.

    PubMed  CAS  Google Scholar 

  • Hahn FJ, Leibrock LG, Huseman CA et al. The MR apperance of hypothalamic harmatoma. Neuroradiology 1988;30:65–8.

    PubMed  CAS  Google Scholar 

  • Haisenleder DJ, Cox ME, parsons SJ, Marshall JC. Gonadotropin-releasing hormone pulses are required to maantain activation of mitogenic-activated protein kinase: role in stimulation of gonadotrope gene expression. Endocrinology 1998;139:3104–11.

    PubMed  CAS  Google Scholar 

  • Haisenleder DJ, Katt JA, Ortolano GA et al. A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadtropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo. Endocrinology 1991;128:509–17.

    PubMed  CAS  Google Scholar 

  • Haisenleder DJ, Yasin M, Marshall JC. Gonadotropin subunit and gonadotropin-releasing hormone receptor geneexpression are regulated by alterations in the frequency of calcium pulsatile signals. Endocrinology 1997; 138:5227–30.

    PubMed  CAS  Google Scholar 

  • Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6.

    PubMed  CAS  Google Scholar 

  • Hardelin JP, Levilliers J, Blanchard S, et al. Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndrome, Human Mol Genet 1993;2:373–7.

    CAS  Google Scholar 

  • Hardelin JP, Levilliers J, del Castillo, et al. Genetic heterogeneity evidenced by low incidence of KAL-1 gene mutations in sporadic cases of gonadotropin-releasing hormone deficiency. Proc Natl acad Sci 1992;89:8190–4.

    PubMed  CAS  Google Scholar 

  • Hardelin JP, Petit C. A molecular approach to the pathophysiology of the X chromosome-linked Kallmanns’ syndrome. Balliere’s Clin Endocrinol Metab 1995;9:489–507.

    CAS  Google Scholar 

  • Hayes FJ, Crowley Jr WF. Gonadotropin pulsations across development. Horm Res 1998;49:163–68

    PubMed  CAS  Google Scholar 

  • Hochman HI, Judge DM, Reichlin S. Precocious puberty and hypothalamic harmatoma. Pediatrics 1981;67:236–244.

    PubMed  CAS  Google Scholar 

  • Holland FJ. Gonadotropin-independent precocious puberty. Endocrinol Metab Clin North Am 1991;20:191–210.

    PubMed  CAS  Google Scholar 

  • Houseknecht KL, Baile CA, Matteri RL, Spurlock ME. The biology of leptin: A review. J Animal Sci 1998;76:1405–20.

    CAS  Google Scholar 

  • Huhtaniemi I, Pettersson K. Mutations and polymorphisms in the gonadotrphin genes; clinical relevance. Clin Endocrinol 1998;48:675–82.

    CAS  Google Scholar 

  • Ibanez L, Potau N, Zampolli M, et al. Use of leuprolide acetate response pattern in the early diagnosis if pubertal disorders: comparison with the gonadotropin-releasing hormone test. J Clin Endocrinol Metab 1994;76:30–5.

    Google Scholar 

  • Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL. The nuclear factor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 1995;9:478–86.

    PubMed  CAS  Google Scholar 

  • Ikeda Y, Swain A, Weber TJ, et al. Steroidogenic facotr 1 and DAX-1 colocolize in multiple cell lineages: potential links in endocrine development. Mol Endocrinol 1996; 10:1261–72.

    PubMed  CAS  Google Scholar 

  • Ikeda Y, Swain A, Weber TJ, et al. Steroidogenic-factor-1 and DAX-1 colocalize in multiple cell lineages-potential links in endocrine development. Mol Endocrinol 1996; 10:12661–72.

    Google Scholar 

  • Ito M, Yu RN, Jameson JL. DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita. Mol Cell Biol 1997;17:1476–83.

    PubMed  CAS  Google Scholar 

  • Judge DM, Kulin HE, Santen R, et al. Hypothalamic harmartoma: a source of lutenizing hormone-releasing factor in precocious puberty. N Eng J Med 1977;296:7–10.

    CAS  Google Scholar 

  • Jung H, Shannon EM, Fritschy JM, Ojeda SR. Several GABA(A) receptor subunits are expressed in LHRH neurons of juvenile female rats. Brain Res 1998;780:218–229.

    PubMed  CAS  Google Scholar 

  • Junier M, Hill DF, Costa ME, Felder S, Ojeda SR. Hypothalamic lesions that induce female precocious puberty activate glial expression of the epidermal growth factor receptor gene: defferential regulation of alternatvely spliced transcripts. J Neuroscience 1993;13:703–13.

    CAS  Google Scholar 

  • Junier M, Ma YJ, Costa ME, Hoffman G, Hill DF, Ojeda SR. Transforming growth factor alpha contributes to the mechanism by which hypothalamic injery induces precocious puberty. Proc Nat Aca Sci USA 1991;88:9743–7.

    CAS  Google Scholar 

  • Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotrpin subunit and GnRH receptor message. Endocrinology 1997; 138:1224–31.

    PubMed  CAS  Google Scholar 

  • Kaiser UB, Sabbagh E, Katzenellenbogen RA Conn PM, Chin WW. A mechanism for the differential regulation of goandotropin subunit gene expression by gonadotropin-releasing hormone. Proc Natl Acad. Sci USA 1995;92:12280–4.

    PubMed  CAS  Google Scholar 

  • Kaiser UR, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev 1997; 18:46–70.

    PubMed  CAS  Google Scholar 

  • Kakar SS, Musgrove LC, Devor DC, Sellers JC, Neill JD. Cloning, sequencing, and expression of human gonadotropin-releasing hormone (GnRH) receptor. Biochem Biophys Res Commun 1992;189:289–95.

    PubMed  CAS  Google Scholar 

  • Kakar SS. Molecular structure of the human gonadotropin-releasing hormone receptor gene. Europ J Endocrinol 1997;137:183–92.

    CAS  Google Scholar 

  • Karten MJ, Rivier JE. Gonadotropin-releasing hormone analog design-structure-function studies toward the development of agonists and antagonists: rationale and prespective. Endocr Rev 1986;7:44–66.

    PubMed  CAS  Google Scholar 

  • Katt JA, Duncan JA, Herbon L, Barkan A, Marshall JC. The frequency of gonadotropin-releasing hormone stimulation determines the number of pituitary gonadotropin-releasing hormone receptors. Endocrinology 1985; 116:2113–5.

    PubMed  CAS  Google Scholar 

  • Keenan BS, Richards GE, Ponder SW, et al. Androgen-stimulated pubertal growth: the effects og testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty. J Clin Endocrinol Metab 1993;76:996–1001.

    PubMed  CAS  Google Scholar 

  • Keloff GJ, Lubet RA, Lieberman R, et al. Aromatase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomark Prevent 1998;7:65–78.

    Google Scholar 

  • Klein KO, Martha PM, Blizzarad RM, et al. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys:II. Estrogen levels as determined by an ultrasenstivie bioassay. J Clin Endocrinol Metab 1996;81:3203–7.

    PubMed  CAS  Google Scholar 

  • Kletter GB, Gorski JL. Kelch RP. Congenital adrenal hypoplasia and isolated gonadotropin deficiency. Trends Endocrinol Metab 1991;2:123–8.

    Google Scholar 

  • Kletter GB, Kelch RB. Clinical Review 60: Effects of gonadotropin-releasing hormone analog therapy on adult stature in precocious puberty. J Clin Endocrinol Metab 1994;79:331–4

    PubMed  CAS  Google Scholar 

  • Kosut SS, Wood RI, Herbosa Encarnacion C, Foster DL. Prenatal androgens time neuroendocrine puberty in the sheep: Effect of testosterone dose. JN-Endocrinology 1997;138:1072–7

    CAS  Google Scholar 

  • Kottler ML, Caron P, Christin-Maitre S, Lagarde JP, Counis R, Bouchard P. A complete familial hypogonadism due to a compound heterozygous mutation of the gonadotropin releasing hormone (GnRH) receptor gene. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27; P2–40.

    Google Scholar 

  • Kremer H, Kraaj R, Toledo SPA, et a. Male pseudohermaphroditism due to homozygous mutation of the luteinizing hormone receptor gene. Nature Gnentics 1995;9:160–4.

    CAS  Google Scholar 

  • Kremer H, Mariman E, Otten BJ, et al. Cosegregation of missense mutations of luteinizing hormone receptor gene with familial male-limited precocious puberty. Hum Mol Genet 1993;2:1779–83.

    PubMed  CAS  Google Scholar 

  • Kulin H, Demers L, Chinchilli V, et al. Usefulness of sequential urinary follicle-stimulating-hormone and luteininzing-hormone measurements in the diagnosis of adolescent hypogonadotropism in males. J Clin Endocrinol Metab 1994;78:1208–11.

    PubMed  CAS  Google Scholar 

  • Kulin HE, Finkelstein JW, D’Arcangelo R, et al. Diversity of pubertal testosterone changes in boys with consitutional delay in growth and/or adolescence. J Pediatr Endocrinol Metab 1997; 10:395–400.

    PubMed  CAS  Google Scholar 

  • Kulin HE. Extensive personal experience. Delayed puberty. J Clin Endocrinol Metab 1996;81:3460–4

    PubMed  CAS  Google Scholar 

  • Kumar TR, Wang Y, Lu N, Matzuk MM. Follicel-stimulating hormone is required for ovarian follicle maturation but not male fertility. Nature Genetics 1997;15:201–4.

    PubMed  CAS  Google Scholar 

  • Lalli E, Bardoni B, Zazopoulos E, et al. A transcxiptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita. Mol Endocrinol 1997; 11:1950–60.

    PubMed  CAS  Google Scholar 

  • Lanes R, Gunczler P, Osuna JA, et al. Effectiveness and limitations of the use of the gonadotropin-releasing hormone agonist leuprolide acetate in the diagnosis of delayed puberty in males. Hormone Research 1997;48:1–4.

    PubMed  CAS  Google Scholar 

  • Latronico AC, Anasti J, Arnhold IJP, et al. Testicular and ovarian resistance to luteinizing hormone receptor gene. N Eng J Med 1996;334:507–12.

    CAS  Google Scholar 

  • Laue L, Kenigsberg D, Pescovitz OH et al. Treatment of familial male precocious puberty with spironolactone and testolactone. N Eng J Med 1989; 320:496–502.

    CAS  Google Scholar 

  • Laue L, Merke DP, Jones JV, Barnes KM, Hill S, Cutler GB. A preliminary study of flutamide, testolactone and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia. J Clin Endcrinol Metab 1996; 81:3535–39.

    CAS  Google Scholar 

  • Lavoie HB, Martin KA, Taylor AE, Croelwy WF, Hall JE. Exaggeerated free alpha-subunit levels during pulsatile gonadotropin-releasing hormone replacement in women with idiopathic hypogonadotropic hypogonadims. J Clin Endocrinol Metab 1998;83:241–7.

    PubMed  CAS  Google Scholar 

  • Layman LC, Amde S, Cohen DP, Jin M, Xie J. The Finnish follicle-stimulating hormone receptor gene mutation is rare in North American women with 46, XX ovarian failure Fertil Steri 1 1998;69:300–2

    CAS  Google Scholar 

  • Layman LC, Cohen DP, Jin M, et al. Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. Nature Genetics 1997; 18:14–5.

    Google Scholar 

  • Layman LC, Cohen DP, Xie J, Li Z, Bick DP, Sherins RJ. The prevalence of gonadotropin-releasing hormone receptor gene mutations in patients with idiopathic hypogonadotropic hypogonadism. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27; P1–344.

    Google Scholar 

  • Layman LC, Lee E-J, Peak DB, et al. Delayed puberty and hypogonadism caused by mutations in the follicle stimulating hormone β-subunit gene. Neng J Med 1997;337:607–11.

    CAS  Google Scholar 

  • Layman LC, Peak DB, Xie J, Sohn SH, Reindollar RH, Gray MR. Mutation analysis of the gonadotropin-releasing hormone receptor gene in idiopathic hypogonadotropic hypogoandism. Fertil Steril 1997;68:1079–85.

    PubMed  CAS  Google Scholar 

  • Lemcke B, Zentgraf J, Behre HM, Kliesch S, Bramswig JH, Nieschlag E. Long-term effects on testicular function of high-dose testosterone treatment for excessive tall stature. J Clin Endocrinol Metab 1996;81:296–301.

    PubMed  CAS  Google Scholar 

  • Levine Ross J, Loriaux DL, Cutler Jr GB. 1983 Development changes in neuroendocrine regulation of gonadotropin secretion in gonadal dysgenesis. J Clin Endocrinol Metab 57: 288–293.

    Google Scholar 

  • Luboshitsky R, Lavi s, Thuma I et al. Increased nocturnal melatonin secretion in male patietns with hypogonadotropic hypogonadism and delayed puberty. J Clin Endocrinol Metab 1995;80:2144–8.

    Google Scholar 

  • Luo X, Ikeda Y, Parker KL. A cell specific nuclear receptro is essential for adrenal and gonadal development and sexual differnetiation. Cell 1994;77:481–90.

    PubMed  CAS  Google Scholar 

  • Ma YJ, Costa ME, Ojeda SR. developmental expression of the genes encoding transforming growth factor alpha (TGF α) snf its receptor in the hypothalamus of the female rhesus macaque. Neuroendocrinol 1994;60:346–59.

    CAS  Google Scholar 

  • Maffei M, Halaas J, Ravussian E, et al. Leptin levies in human and rodent: measurement of leptin and Ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1:1155–61.

    PubMed  CAS  Google Scholar 

  • Magoffin DA, Huang CTF. Leptin and reproduction. Endocrinologist 1998;8:79–86.

    Google Scholar 

  • Mahachoklertwattana P, Kaplan SL, Grumbach MM. The luteinizing hormone releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history. J Clin Endocrinol Metab 1993;77:118–24.

    PubMed  CAS  Google Scholar 

  • Mahler C, Verhelst J, Denis L. Clinical pharmacokinetics of the antiandrogens and thier efficacy in prostate cancer. Clinical Pharmacokinetics 1998;34:405–17.

    PubMed  CAS  Google Scholar 

  • Marin G, Domene M, Barnes KM, et al. The effect of estrogen priming and puberty on the growth hormone response to stnadardized treadmill, exercise, and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab 1994;79:537–41.

    PubMed  CAS  Google Scholar 

  • Martin MM, Wu SM, Martin ALA, Rennert OM, Chan WY. Malignant seminoma in a patient with a consitutive activating mutation of the LH receptor. Horm Res 1997;48(Supp 2): 118.

    Google Scholar 

  • Martinez de la Escalera G, Choi ALH, Weiner. Generation and synchronisation of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 1992;89:1852–55.

    Google Scholar 

  • Mason AJ, Hayflick JS, Zoeller RT, et al. A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 1986;234:1366–71.

    PubMed  CAS  Google Scholar 

  • Mathews C, Nystrom E, Lindstedt, Williams D, Chatterjee VKK. Differing roles of FSH in human versus murine isolated FSH deficiency. J Endocrinol 1998; 156 Supp:P251

    Google Scholar 

  • Mathews CH, Bogato S, Beck-pecoz P, et al. Primary amenorrhoea and infertility due to a mutation in the β-subunit of follicle-stimulating hormone. Nature Genetic 1993;5:83–6.

    Google Scholar 

  • Mathews CH, Chatterjee VK. Isolated deficiency of follicle stimulating hormone re-visited. N Eng J Med 1997;337:642.

    Google Scholar 

  • Matsumoto AM, Bremner WJ. Modulation of pulsatile gonadotropin secretion by testosterone in ma. J Clin Endcrinol Metab 1984;58:609–14.

    CAS  Google Scholar 

  • Mauras N, Veldhuis JD, Rogol AD. Role of endogenous opiataes in pubertal maturation: opposing actions of naltrexone in prepubertal and late pubertal boys. J Clin Endocrinol Metab 1986;62:1256–63.

    PubMed  CAS  Google Scholar 

  • McCabe ERB, In The Metabolic and Molecular Basis of Inherited Diseases. 7yh Edn. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle eds. New York: McGraw-Hill, 1995. pp1631–52.

    Google Scholar 

  • McGillivray MH, Morishima A, Conte F, Grumbach M, Smith EP. The essential roles of estrogens in pubertal growth, epiphyseal fusion and bone turnover: lessons from mutations in the genes for aromatse and the estrogen receptor. Horm Res 1998;49(supp1):2–8.

    Google Scholar 

  • Metzger DL, Kerrigan JR. Estrogen receptor blockade with tamoxifen diminishes growth hormoen secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolesence. J Clin Endocrinol Metab 1994;79:513–8.

    PubMed  CAS  Google Scholar 

  • Metzger MD, Kerrigan JR, Rogol AD. Gonadal steroid hormone regulation of the somatotropic axis dyring puberty in humans: mechanisms of androgen and estrogen action. Trends Endocrinol Metab 1994;5:290–6.

    CAS  Google Scholar 

  • Mitsushima D, Hei DL. Terasawa E. G-aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty. Proc Natl Acad Sci USA. 1994;91:395–99.

    PubMed  CAS  Google Scholar 

  • Mitsushima D, Marzban F, Luchansky LL et al. Role of glutamic acid decarboxylase in the prepubertal inhibition of the luteinizing-hormone releasing hormone release in female rhesus monkeys. J Neiroendocrinol; 1996:2563–73.

    Google Scholar 

  • Monasco P, Umbach DM, Mully SM, Godwin DC, Negro-Vilar A, Culler MD, Underwood LE. Ontogeny of gonadotropin, testosterone and inhibin secretion in normal boys through puberty based on overnight serial sampling. J Clin Endocrinol Metab 1995;802046–52.

    Google Scholar 

  • Montzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys.V. Rising leptin levies may signal the onset of puberty. J Clin Endocrinol metab 1997;82:1066–70.

    Google Scholar 

  • Morishima A, Grumbach MM, Simpson ER, Fisher C, Kenan Q. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogen. J Clin Endocrinol Metab 1995;80:3689–98.

    PubMed  CAS  Google Scholar 

  • Munuz-Torres M, Jodar E, Quesada M, Escobar-Jiminez F. Bone mass in androgen-insenstive syndrome: response to hormone replacement thearpy. Calcif Tissue Int 1995;57:94–6.

    Google Scholar 

  • Muscatelli F, Strom TM, Walker AP, et al. Mutations in the DAX-1 gene give rise to both X-liinked adreanl hypoplasia congenita and hypogonadotropic hypogonadism. Nature 1994;372:672–6.

    PubMed  CAS  Google Scholar 

  • Nachtigal MW, Hirokawa Y, Enyeart van Houten DL, et al. Wilm’s tumour 1 and DAX-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell 1998;93:445–54.

    PubMed  CAS  Google Scholar 

  • Nachtigall LB, Boepple PA, Pralong FP, Crowley Jr WF. Adult-onset with idiopathic hypogonadotropic hypogonadism-a treatble form of male infertility. N Eng J Med 1997;336:410–5.

    CAS  Google Scholar 

  • Nagatani S, Guthikonda P, Thompson RC, et al. Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting Neuroendocrinology 1998;67:370–8.

    PubMed  CAS  Google Scholar 

  • Nakayama Y, Wondisford FE, Lash RW, et al. Analysis of gonadotropin-releasing hormone gene in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1990;70:1233–8.

    PubMed  CAS  Google Scholar 

  • Naor Z, Harris D, Shacham S. Mechanism of GnRH receptor signalling: combinatorial cross-talk of Ca2+ and protein kinase C. Frontiers Neuroendocrinol 1998; 19:1–19.

    CAS  Google Scholar 

  • Nathawani NC, Hindmarsh PC, Massarano AA, Brook CGD. Gonadotropin pulsatility in girls with the Turner Syndrome: modification by exogenous sex steroids. Clin Endocrinol 1998;49:107–13.

    Google Scholar 

  • Neely E, Hintz R, Wilson D. Normal ranges for immunochemiluminescent gonadotrpin assay. J Pediatr 1995;127:40–6.

    PubMed  CAS  Google Scholar 

  • Oerter KE, Uriarte M, Rose SR, Barnes KM, Cutler Jr GB. Gonadotrohin secretory dynamics during puberty in normal boys and girls.. J Clin Endocrinol Metab 1990;71:1251–8

    PubMed  CAS  Google Scholar 

  • Ojeda SR. The transforming growth factor alpha gene family is involved in the neuroendocrine control of mammalian puberty. Molec Psych 1997;2:355–8.

    CAS  Google Scholar 

  • Ozata M, Bulur M, Bingol N. Daytime plasma melatonin levels in malae hypogonadism. J Clin Endocrinol Metab 1996;81:1877–81.

    PubMed  CAS  Google Scholar 

  • Papadimitriou A, Wacharasindhu S, Pearl K, et al. Treatment of consitutional grwth delay in prepubertal boys with a prolonged course of loew-dose oxandrolone. Arch Dis Child 1991;66:841–3.

    PubMed  CAS  Google Scholar 

  • Paul D, Conte FA, Grumbach MM, et al. Long-term effect of gonadotropin-releasing hormone agonist therapy on final and near-final height in 26 children with true precocious puberty treated at a median age of less than 5 years. J Clin Endocrinol Metab 1995;80:546–51.

    PubMed  CAS  Google Scholar 

  • Perera AD, Lagenaur CF, Plant TM. Postnatal expression of polysilicacid-neutral cell adhesion molecule (PSA-NCAM) in the hypothalamus of the male rhesus monkey (Macaca mulatta). Endocrinology 1993; 133. 2729–35.

    PubMed  CAS  Google Scholar 

  • Perera AD, Plant TM. Ultrastructural studies of neuronal correlates of the pubertal reaugmentation of hypothalamic gonadotropin-releasing hormone (GnRH) in the rhesus monkey (macaca mulatta). J Comp Neurol 1997;385:71–82.

    PubMed  CAS  Google Scholar 

  • Pescovitz OH, Comite F, Hench K, et al. The NIH experience with precocious puberty: diagnosis subgroups and response to short-term luteinizing hormone-releasing hormone analogue therapy. J Pediatr 1986; 108:47–54.

    PubMed  CAS  Google Scholar 

  • Peter M, Vieman M, Partsch CJ, Sippell WG. Congenital adrenal hypoplasia: Clinical spectrum, experience with hormonal diagnosis and report on new point mutations of the DAX-1 gene. J Clin Endocrinol Metab 1998;83:2666–74.

    PubMed  CAS  Google Scholar 

  • Petraglia F, Bernasconi S, Iughetti L et al. Naloxone-induced luteinizing hormone secretion in normal, precocious and delayed puberty. J Clin Endocrinol Metab 1986;63:1112–6.

    PubMed  CAS  Google Scholar 

  • Phillip M, Arbelle JE, Segev Y, Parvari R. Male hypogonadism due to a mutation in the gene for the β-subunit of follicle-stimulating hormone. N Eng J Med 1998;338:1729–32.

    CAS  Google Scholar 

  • Pincus SM. Quantifying complexity and regularity of neurobiological systems. Methods Neurosci 1995;28:336–63.

    CAS  Google Scholar 

  • Plant TM & Lee PA. eds The Neurobiology of Puberty, Bristol: Journal of Endocrinology Ltd. 1995

    Google Scholar 

  • Plant TM, Durrant AR. Circulating leptiin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (macaca mulatta). Endocrinology 1997; 138:4505–8.

    PubMed  CAS  Google Scholar 

  • Plant TM, Gay VL, Meashall GR, Arslan M. Puberty in monkeys is triggered by chemical stimulation. Proc Natl Acad Sci USA 1989;86:2506–10.

    PubMed  CAS  Google Scholar 

  • Plant TM. “Puberty in primates” In The physiology of Reproduction, Second Edition, E. Knobil and J.D. Neill eds., New York: Raven Press Ltd 1994, pp 453–485.

    Google Scholar 

  • Plant TM. A study of the postnatal testes in determining the ontogeny of gonadotrpin secretion in the male rhesus monkey (macaca mulatta). Endocrinology 1985; 116:288–93.

    Google Scholar 

  • Plant TM. Gonadal regulation of hypothalamic gonadotropin-releasing hormone in primates. Endo Rev 1986;7:75–88.

    CAS  Google Scholar 

  • Pohl CR, de Ridder CM, Plant TM. Gonadal and nongondal mechanisms contribute to the prepubertal hiatus in gonadotrpin secretion in the female rhesus monkey (macaca mulatta). J Clin Endocrinol Metab 1995; 80:2094–2101.

    PubMed  CAS  Google Scholar 

  • Pollymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540–3.

    Google Scholar 

  • Pralong F, Pavlou SN, Waldstreicher J, Crowley WF, Boepple PA. Defective regulation of glycoprotein free alpha-subunit in males with isolated gonadotropin-rreleasing hormone deficiency-A clinical centre study. J Clin Endocrinnol Metab 1995;80:3682–88.

    CAS  Google Scholar 

  • Pralong FP, Gomez F, Castillo E, Giacomini M, Portmann L, Gaillard RC. Idiopathic hypogonadotropic hypogonadism associated with a novel mutation in the GnRH receptor gene. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27; P2–505.

    Google Scholar 

  • Quigley CA, de Bellis A, Marschke KB, et al. Androgen receptor defects: historical, clinical and molecular perspeective. Endocr Rev 1995; 16:271–95.

    PubMed  CAS  Google Scholar 

  • Quinton R, Duke VM, de Zoysa PA, et al. The neuroradiology of Kallmann’s syndrome: a genotype and phenotype analysis. J Clin Endocrinol Metab 1996;81:3010–7.

    PubMed  CAS  Google Scholar 

  • Raivio T, Huhtaniemi I, Antilla R, et al. The role of luteinizing hormone-b gene polymorphism in the onset and progression of puberty in healthy boys. J Clin Endocrinol Metab 1996;81:3278–82.

    PubMed  CAS  Google Scholar 

  • Richman RA, Kirsch LR. Testosterone treatment in adolesent boys with constitutional delay in growth and development. N Eng J Med 1988;319:1563–7.

    CAS  Google Scholar 

  • Ringle MD, Schwindinger WT, Levine MA. Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditery osteodystrophy. Medicine 1996;75:171–84.

    Google Scholar 

  • Rogol AD. Growth at puberty: interaction of androgen and growth hormone. Med Sci Sport Exerc 1994;26:767–770.

    CAS  Google Scholar 

  • Rosenthal SM, Grumbach MM, Kaplan SL. Gonadotropin-independent familial sexual precocity with premature Leydig and germial cell maturation (familial testotoxicosis): effects of a potent luteiniaing hormone releasing factor agonist and medroxyprogesterone acetate therapy in four cases. J Clin Endocrinol Metab 1983;57:571–9.

    PubMed  CAS  Google Scholar 

  • Rugarli El, Ghezzi M, Valsecchi V, Ballabio A. The Kallmann syndrome gene product expressed in COS cells is cleaved on the cell surface to yield a diffusable component. Human Mol Genet 1996;5:1109–15.

    CAS  Google Scholar 

  • Schedewie HK, Reiter EO, Beitins IZ. Testicular Leydig cell hyperplasia as a cause of familial sexual precocity. J Clin Endocriol Metab 1981;52:271–8.

    CAS  Google Scholar 

  • Schroor EJ, van Weissenbruch MM, Delemarre-Van de Waal HA. Long-term GnRH-agonist treatment does not postpone central development of the GnRH pulse generator in girls with idiopathic precicious puberty. J Clin Endocrinol Metab 1995;80:1696–1701.

    PubMed  CAS  Google Scholar 

  • Schwanzel-Fukuda M, Bick D, Pfaff DW. Luteinizing hormone-releasing hormone (LHRH)-expressing neurons in early human embryos. J Comp Neurol 1996;366:547–57.

    PubMed  CAS  Google Scholar 

  • Schwanzel-Fukuda M, Bick DP, Pfaff DW. Luteinizing hormone-releasing hormone (LHRH) expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol Brain Res 1989;6:311–26.

    PubMed  CAS  Google Scholar 

  • Shenker A, Laue L, Kosugi S, et al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature 1993;365:652–4.

    PubMed  CAS  Google Scholar 

  • Silverman AJ, Livine I, Witkin JW. The gonadotropin-releasing hormone (GnRH) neuronal systems: Immnocytohistochemistry and in situ hybridization In The physiology of Reproduction, Second Edition, E. Knobil and J.D. Neill eds., New York: Raven Press Ltd. 1994, pp 1683–1709.

    Google Scholar 

  • Silverman RC, Gibson MJ, Silverman A. Relationship of glia to GnRH axonal outgrowth from the third ventriclular grafts in the hpg host. Exp Neurol 1991;114:259–74.

    PubMed  CAS  Google Scholar 

  • Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: Biochemistry, molecular niology, physiology, and pathophysiology. Endo Rev 1997;18:739–73.

    CAS  Google Scholar 

  • Smals AG, Hermus AR, Boers GH, et al. Predictive value of luteinizing hormone releasing hormone (LHRH) bolus testingg befeore and after 36-hour pulsatile LHRH administration in the differential diagnosis of consitutional delay of puberty and male hypogonadotropic hypogonadism. J Clin Endocrinnol Metab 1994;78:602–8.

    CAS  Google Scholar 

  • Smals AGH, Kloppenborg PWC, van Haelst UJG, et al. Fertile eunuch syndrome versus classic hypogonadotropic hypogonadism. Acta Endocrinol 1978;87:389–99.

    PubMed  CAS  Google Scholar 

  • Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogenreceptor gene in a man. N Eng J Med 1994;331:1056–61.

    CAS  Google Scholar 

  • Soussi-Yanicostas N, Hardelin JP, del Mar Arroyo-Jimenez M, et al. Initial characterization of anosmin-I, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system. J Cell Sci 1996;109:1749–57.

    PubMed  CAS  Google Scholar 

  • Spiegel AM. Mutations in G proteins and G protein-coupled receptors in endocrine disease. J Clin Endocrinol Metab 1996;81:1434–42.

    Google Scholar 

  • Spratt DI, Carr DB, Merriam GR, et al. The spectrum of abnormal patterns of gonadotropin-releasing hormone secretion in men with idiopathic hypogonadotropic hypogonadism: clinical and laboratory correlations. J Clin Endocrinol Metab 1987;64:283–91.

    PubMed  CAS  Google Scholar 

  • Stanhope R, Buchanan CR, Fenn GC, Preece MA. Double blind placebo controlled trial of loe dose oxandrolone in the treatment of boys wiwth consitutional delay of growth and puberty. Arch Dis Child 1988;63:501–5.

    PubMed  CAS  Google Scholar 

  • Stephens TW, Basinski M, Bristow PK, et al. A role for neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995;377:530–2.

    PubMed  CAS  Google Scholar 

  • Strickland AL. Long-term results of treatment with low-dose fluoxymesterone in consitutional delay of growth and puberty and in generic short stature. Pediatrics 1993;91:716–20.

    PubMed  CAS  Google Scholar 

  • Suganuma N, Furui K, Kikkawa F, Tomoda Y, Furuhashi M. Effects of the mutation (Trp8-Arg and Ile15-thr) in human luteinnizing hormone (LH) β-subunit on LH bioactivity in vitro and in vivo. Endocrinology 1996; 137:831–8.

    PubMed  CAS  Google Scholar 

  • Sutter KJ, Pohl CR, Plant TM. The pattern and tempo of the pubertal reaugmentation of open-loop pulsatile gonadotropin-releasing hormone release assessed indirectly in the male rhesus monkey (macaca mulatta). Endocrinology; 1998:139:2774–83.

    Google Scholar 

  • Swain A, Narvarez V, Burgoyne P, Camerino G, Lovell-Badge R. Dax-1 antagoniszes Sry action in mammalian sex dertermination. Nature 1998;391:761–7.

    PubMed  CAS  Google Scholar 

  • Swain A. Lovell-Badge R. A molecular approach to sex determination in mammals. Acta Pediatrica 1997;86:46–9.

    Google Scholar 

  • Takahashi T, Shoji Y, Haragouchi N, et al. Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adreanl hypoplasia congenita. J Peadiatr 1997; 130–485–8.

    Google Scholar 

  • Tanner JM, Whitehouse RH, Hughes PCR, et al. Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length and muscle width in growth hormone-deficient children. J Pediatr 1976;89:1000–8.

    PubMed  CAS  Google Scholar 

  • Tapanainen JS. Aitomaki K, Jiang M, Vaskivuo T, Huhtaniemi IT. Men homozygous for an inactivating mutation of the follicel-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nature Genetics 1997; 15:205–6.

    PubMed  CAS  Google Scholar 

  • Taylor AE, Khoury RH, Crowley Jr WF. A comparison of 13 different immunometric assaykits for gonadotrpins: implications for clinical investigation. J Clin Endocrinol and Metab 1994;79:240–7.

    CAS  Google Scholar 

  • Terasawa E, Luchansky LL, Kasauya E. An increase in glutamate release follows a decrease in gamma Aminobutyric acid (GABA) and the pubertal increase in LHRH release in female rhesus monkeys. The 80th Annual Meeting of the Endocrine Society, New Orleans LA, 1998 June 24–27; OR5–2.

    Google Scholar 

  • Terasawa E. Mechanisms controlling the onset of puberty in primates: the role of GABAergic neurons. In The Neurobiology of Puberty T.M. Plant & P.A. Lee, eds. Bristol: Journal of Endocrinology Ltd. 1995, pp 139–51.

    Google Scholar 

  • Urbanski HF, Ojeda SR. Activation of luteinizing-Hormone Releasing Hromone release advances the onset of female puberty. Neuroendocrinol 1987;46:273–6.

    CAS  Google Scholar 

  • Urbanski HF, Pau KYF. A biphasic developmental pattern of circulating leptin in the male rhesus macaque (Macaca mulatta). Endocrinology 1998; 139:2284–6.

    PubMed  CAS  Google Scholar 

  • Uriate MM, Baron J, Garcia HB, et al. The effects of pubertal delay on adult height in men with isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1992;74:436–440.

    Google Scholar 

  • Uruena M, Pantsiotou S, Preece MA, et al. Is testosterone therapy for boys with constitutional delay of growth and puberty associated with impaired final height and suppression of the hypothalamic-pituitary gonadal axis? Eur J Pediatr 1992; 151:15–18.

    PubMed  CAS  Google Scholar 

  • Veldhuis JD, Johnson ML. Deconvolution analysis of hormone data. Method Enzymol. 1992;210:539–575.

    CAS  Google Scholar 

  • Waldstreicher J, Seminar SB, Jameson JL, et al. The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human. J Clin Endocrinol Metab 1996;81:4388–95.

    PubMed  CAS  Google Scholar 

  • Watanabe G, Terasawa E. In vivo release of luteinizing hormone releasing hormone increases with puberty in the female rhesus monkey. Endocrinology 1989; 125:92–99.

    PubMed  CAS  Google Scholar 

  • Weinstein LS, Shenker A, Gejman PV, et al. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Eng J Med 1991;325:1688–95.

    CAS  Google Scholar 

  • Weiss H, Axelrod L, Whitcomb RW, Harris PE, Crowley Jr WF, Jameson JL. Hypogonadism caused by a single amino acid subsitutition in the beta subunit of the luteinizing hormone. N Eng J Med 1992;326:179–83.

    CAS  Google Scholar 

  • Weiss J, Adam E, Whitcomb RW, Crowley Jr WF, Jameson JL. Normal sequence of the gonadotropin-releasing hormone gene in patients with and idiopathic hypogonadotropic hypogonadism. Biol Reprod 1991;45:743–7.

    PubMed  CAS  Google Scholar 

  • Weiss J, Crowley Jr WF, Jameson JL. Normal structure of the gonadotropin-releasing hormone (GnRH) gene in patients with GnRH deficiency and idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1989;69:299–303.

    PubMed  CAS  Google Scholar 

  • Wennick JMB, Delemarre Van-Der Waal HA, van Kessel H, Mulder GH, Foster JP, Schoemaker J. Luteinizing hormone secretion patterns in boys at the onset of puberty measured using a highly sensitive immunoradiometric assay. J Clin Endocrinol Metab 1988;67: 924–8.

    Google Scholar 

  • Wetsel W, Valenca MM, Merchenthaler I et al. Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons. Proc Natl Acad Sci USA 1992;89:4149–53

    PubMed  CAS  Google Scholar 

  • Wierman ME, Beardsworth DE, Mansfield MJ et al. Puberty without goandotropins: a unique mechanism of sexual development. N Eng J Med 1985;312:65–72.

    CAS  Google Scholar 

  • Witkin JW, Ferin M, Popilskis SJ, Silverman A. Effeccts of gonadal steroids on the ultrastructure of GnRH neurons in the rhesus monkey: synaptic input and glial apposition. Endocrinology 1991;129:1083–92.

    PubMed  CAS  Google Scholar 

  • Wu FCW, Borrow SM, Nicol K, Elton R, Hunter WM. Ontogeny of pulsatile gonadotropin secretion and pituitary responsiveness in male puberty in man-a mixed longitudinal and cross-sectional study. J Endocrinol 1989; 123:347–59.

    PubMed  CAS  Google Scholar 

  • Wu FCW, Brown DC, Butler GE Kelnar CJH, Stirling HF. Early morning testosterone is an accurate predictor of imminent pubertal development in boys with constitutional delayed growth and puberty. J Clin Endocrinol Metab 1993;76: 26–31.

    PubMed  CAS  Google Scholar 

  • Wu FCW, Butler GE, Kelnar CJH, Huhtaniemi I, Veldhuis JD. Ontogeny of pulsatile gonadotropin-releasing hormone secretion from midchildhoos, through puberty to adulthood in the human male: a study using deconvolution analysis abd an ultrasensitive immunofluorometric assay. J Clin Endocrinol Metab 1996;81:1798–1805.

    PubMed  CAS  Google Scholar 

  • Wu FCW, Butler GE, Kelnar CJH, Stirling HF, Huhtaniemi I. Patterns of pulsatile luteinizing and follicle stimulating hormone secretion in prepubertal (midchildhood) boys and girls and patients with idiopathic hypogonadotrophic hypogonadsim (Kallmann’s syndrome): a study using an ultrasensitive time-resolved immunofluorometric assay. J Clin Endocrinol Metab 1991;72:1229–37.

    PubMed  CAS  Google Scholar 

  • Wu FCW, Howe DC, Naylor AM. N-methyl-D-aspartate (NMDA) receptor antagonism by D-2-amino-5-phosphonovaleric acid delays onset of puberty in the female rat. J Neuroendocrinol 1990;2:627–31.

    Google Scholar 

  • Wu FCW. GnRH pulse generator activity during human puberty. In The Neurobiology of Puberty T.M. Plant & P.A. Lee, eds. Bristol: Journal of Endocrinology Ltd.1995, pp185–98.

    Google Scholar 

  • Yanase T, Takayanagi R, Oba K, et al. New mutations of SAX-1 genes in two Japaneses patients with X-linked congenital adreanl hypoplasia and hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1996;81:530–5

    PubMed  CAS  Google Scholar 

  • Yu RN, Ito M, Jameson JL. The murine DAX-1 promotor is stimulated by SF-1 (steroidogenic facotr-1) and inhibited by COUP-TF (chicken ovalbumin upstream promotor transcription facotr) via a composite nuclear receptor regulatory element. Mol Endocrinol 1998; 12:1010–22.

    PubMed  CAS  Google Scholar 

  • Zachman M, Prader A, Sobel EH, et al. Pubertal growth in patients with androgen insensitivity: indirect evidence for the importance of estrogens in pubertal growth of girls. J Pedtiatr 1986; 108:694–7.

    Google Scholar 

  • Zachman M, Studer S, Prader A. Short-term testosterone treatment at bone age 12 to 13 years does not reduce adult height in boys with constitutional delay of growth and adolescence. Helv Paediatr Acta 1987;42:21–8.

    Google Scholar 

  • Zamboni G, Antoniazzi F, Tato L. Use of the gonadotropin-releasing hormone agonist triptorelin in the diagnosis of delayed puberty in boys. J Pediatr 1995;126:756–8.

    PubMed  CAS  Google Scholar 

  • Zamorano PL, Mahesh VB, de Sevilla L, Brabb DW. Excitatory amino acid receptors and puberty. Steroids 1998;63:268–70.

    PubMed  CAS  Google Scholar 

  • Zhang Y, Pronca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–32.

    PubMed  CAS  Google Scholar 

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  1. Saint Mary’s Hospital, Whitworth Park, Manchester, UK

    F. C. W. Wu

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  1. Harbor-UCLA Medical Center, Torrance, California, USA

    Christina Wang M.D.

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© 1999 Kluwer Academic Publishers

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Wu, F.C.W. (1999). Male Puberty and Its Disorders. In: Wang, C. (eds) Male Reproductive Function. Mineralogical Society Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38145-9_5

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  • DOI: https://doi.org/10.1007/978-0-585-38145-9_5

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