Paracrine Control of Testis Function

  • B. Jégou
  • C. Pineau
  • A. Dupaix
Part of the Mineralogical Society Series book series (ENDO, volume 5)


Two concepts have been put forward to explain the regulation of testicular function. Firstly, it has been suggested that testicular function is regulated primarily by pituitary gonadotropins (endocrine regulation). Secondly, it has been proposed that the “testis is not a mass of independently developing cells” (Roosen-Runge, 1952), so there are presumably local regulatory mechanisms to coordinate the activities of testicular cells (paracrine regulation). It is now generally accepted that there is no conflict between the concepts of peripheral control of testicular function and intratesticular control. The integration of these two concepts accounts for gonadotrophins regulating testicular paracrine activities and some paracrine factors regulating the testicular effects of pituitary hormone and exerting endocrine control over pituitary function.


Germ Cell Sertoli Cell Leydig Cell Seminiferous Tubule Seminiferous Epithelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1999

Authors and Affiliations

  • B. Jégou
    • 1
  • C. Pineau
    • 1
  • A. Dupaix
    • 1
  1. 1.INSERMUniversity of RennesRennes CedexFrance

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