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Modern Management of Male Infertility

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Male Reproductive Function

Part of the book series: Mineralogical Society Series ((ENDO,volume 5))

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Abstract

About 15% of couples do not achieve a pregnancy within 12 months of trying to have a child. The man may have a disorder that accounts for, or contributes to the low fertility in up to 50% of these couples (Baker 1995a). Investigation or infertility should, from the outset involve both the man and the woman. Some treatable or reversible conditions cause male infertility but most often nothing can be done to the man to increase the chance of natural conception. Assisted reproductive technology, particularly intracytoplasmic sperm injection (ICSI) with in vitro fertilization (IVF) or donor insemination is particularly helpful for these otherwise untreatable types of male infertility.

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References

  • Aitken JA, Baker HWG. Seminal leukocytes: passengers, terrorists or good Samaritans? Hum Reprod 1995;10:1736–9

    PubMed  CAS  Google Scholar 

  • Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS, Wu FC. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl 1989;10:214–20

    PubMed  CAS  Google Scholar 

  • Anguiano A, Oates R.D, Amos J.A, Dean M, Gerrard B, Stewart C, Mather T.A, White MB, Milunsky A. Congenital bilateral absence of the vas deferens a primary genital form of cystic fibrosis. JAMA 1992;267:1794–7

    Article  PubMed  CAS  Google Scholar 

  • Baker HWG, Burger HG, de Kretser DM, Hudson B, Rennie GC, Straffon WGE. Testicular vein ligation and fertility in men with varicoceles. Br Med J 1985;291:1678–80

    CAS  Google Scholar 

  • Baker HWG, Clarke GN, Hudson B, McBain JC, McGowan M.P, Pepperell RJ. Treatment of sperm autoimmunity in men. Clin Reprod Fertil 1983;2:55–71

    PubMed  Google Scholar 

  • Baker HWG. Male Infertility. In Endocrinology 3rd Edition De Groot LJ (Chief Ed) W Saunders Co Orlando Fl 1995a;134:2404–33

    Google Scholar 

  • Baker HWG. Medical treatment for idiopathic male infertility: is it curative or palliative? In Van Steirteghem A, Tournaye H, Devroey P. Male Infertility. Bailliere’s Clinical Obstetrics and Gynaecology (in press) 1998

    Google Scholar 

  • Baker HWG. Testicular function in systemic disease. In Principles and Practice of Endocrinology and Metabolism 2nd Edition Becker KL (Chief Ed) Endocrinology of Man, Bremner WJ (Ed) JB Lippincott Co Philadelphia, 115:1083–9, 1995b.

    Google Scholar 

  • Bhasin S, de Kretser DM, Baker HWG. Pathophysiology and natural history of male factor infertility. J Clin Endocrinol Metab 1994;79:1525–9

    Article  PubMed  CAS  Google Scholar 

  • Bourne H, Liu DY, Clarke GN, Baker HWG. Normal fertilization and embryo development by intracytoplasmic sperm injection of round-headed acrosomeless sperm. Fertil Steril 1995b;63:1329–32

    PubMed  CAS  Google Scholar 

  • Bourne H, Stern K, Clarke G, Pertile M, Speirs A, Baker HWG, Delivery of normal twins following the intracytoplasmic injection of sperm from a patient with 47, XXY Klinefelter’s syndrome. Hum Reprod 1997; 12:2447–50

    Article  PubMed  CAS  Google Scholar 

  • Bourne H, Watkins W, Speirs A, Baker HWG. Pregnancies after intracytoplasmic injection of sperm collected by fine needle biopsy of the testis. Fertil Steril 1995a;64:433–6

    PubMed  CAS  Google Scholar 

  • Brown-Woodman PDC, Post EJ, Goss GC & White IG. The effect of a single sauna exposure on spermatozoa. Arch Androl 1984;12:9–15

    PubMed  CAS  Google Scholar 

  • Burger HG, Baker HWG. Therapeutic considerations and results of gonadotropin treatment in male hypogonadotropic hypogonadism. Ann NY Acad Sci 1984;438:447–53

    Article  PubMed  CAS  Google Scholar 

  • Clarke GN, Bourne H, Baker HWG. Intracytoplasmic sperm injection for treating infertility associated with sperm autoimmunity. Fertil Steril 1997;68:1–6

    Article  Google Scholar 

  • Clarke GN, Bourne H, Hill P, Johnston WIH, Speirs A, McBain JC, Baker HWG. Artificial insemination and in-vitro fertilization using donor spermatozoa: a report on 15 years of experience. Hum Reprod 1997; 12:722–6

    Article  PubMed  CAS  Google Scholar 

  • Crosignani PG, Walters DE. Clinical pregnancy and male subfertility; the ESHRE multicentre trial on the treatment of male subfertility. Hum Reprod 1994;9:1112–8

    PubMed  CAS  Google Scholar 

  • Cummins JM, Jequier AM, Kan R. Molecular biology of human male infertility links with aging, mitochondrial genetics and oxidative stress? Mol Reprod Dev 1994;37:345–62

    Article  PubMed  CAS  Google Scholar 

  • Duleba AJ, Rowe TC, Ma P, Collins JA. Prognostic factors in assessment and management of male infertility. Hum Reprod 1992;7:1388–93

    PubMed  CAS  Google Scholar 

  • Garrett C, Baker HWG, A new fully automated system for the morphometric analysis of human sperm heads. Fertil Steril1995;63:1306–17

    PubMed  CAS  Google Scholar 

  • Gromoll J, Simoni M, Nieschlag E. An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. J Clin Endocrinol Metab 1996;81:1367–70

    Article  PubMed  CAS  Google Scholar 

  • Harari O, Bourne H, McDonald M, Richings N, Speirs AL, Johnston WIH, Baker HWG. Intracytoplasmic sperm injection: a major advance in the management of severe male subfertility. Fertil Steril 1995;64:360–8

    PubMed  CAS  Google Scholar 

  • Hargreave TB. Debate on the pros and cons of varicocele treatment-in favour of varicocele treatment. Hum Reprod 1995; 10:suppll:151–7

    PubMed  Google Scholar 

  • Hendry WF, Hughes L, Scammell G, Pryor JP, Hargreave TB. Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa. Lancet 1990;335:85–8

    Article  PubMed  CAS  Google Scholar 

  • Hendry WF, A’Hern RP, Cole PJ. Was Young’s syndrome caused by exposure to mercury in childhood. Br Med J 1993;307:1579–82

    Article  CAS  Google Scholar 

  • Howards SS. Treatment of male infertility. New Engl J Med 1995;332:312–7

    Article  PubMed  CAS  Google Scholar 

  • Kotoulas IG, Cardamakis E, Michopoulos J, Mitropoulos D, Dounis A. Tamoxifen treatment in male infertility. 1. Effect on spermatozoa. Fertil Steril1994;61:911–4

    PubMed  CAS  Google Scholar 

  • Leifke E, Nieschlag E. Evidence based andrology: the importance of controlled clinical trials. In Hansson V, Levy FO & Taqsken K (Eds) Signal transduction in testicular cells. 287–306 Berlin: Springer, 1996.

    Google Scholar 

  • Lim TC, Mallidis C, Hill ST, Skinner DJ, Carter PD, Brown DJ, Baker HWG. A simple technique to prevent retrograde ejaculation during assisted ejaculation. Paraplegia 1994;32:142–9

    PubMed  CAS  Google Scholar 

  • Liu DY, Baker HWG. Disorderd acrosome reaction of sperm bound to the zona pellucida: a newly discovered sperm defect with reduced sperm-zona pellucida penetration and reduced fertilization in vitro. Hum Reprod 1994;9:1694–700

    PubMed  CAS  Google Scholar 

  • Liu DY, Baker HWG. Tests of human sperm function and fertilization in vitro. Fertil Steril 1992;58:465–83

    PubMed  CAS  Google Scholar 

  • Liu DY, Bourne H, Baker HWG. High fertilization and pregnancy rates after intracytoplasmic sperm injection in patients with disordered zona pellucida-induced acrosome reaction. Fertil Steril1997;67:955–8

    Article  PubMed  CAS  Google Scholar 

  • Liu DY, Clarke GN, Baker HWG. Inhibition of human sperm-zona pellucida and spermoolemma binding by antisperm antibodies. Fertil Steril1991;55:440–2

    PubMed  CAS  Google Scholar 

  • Mallidis C, Baker, HWG. Fine needle tissue aspiration biopsy of the testis. Fertil Steril 1994;61:367–75

    PubMed  CAS  Google Scholar 

  • Mallidis C, Howard EJ, Baker HWG. Variation of semen quality in normal men. Int J Androl 1991; 14:99–107

    PubMed  CAS  Google Scholar 

  • Najmabadi H, Huang V, Yen P, Subbarao MN, Bhasin D, Banaag L, Naseeruddin S, de Kretser DM, Baker HWG, McLachlan RI, Loveland KA, Bhasin S. Substantial prevalence of microdeletions of the Y-chromosome in infertile men with idiopathic azoospermia and oligozoospermia detected using a sequence-tagged site-based mapping strategy. J Clin Endocrinol Metab 1996;81:1347–52

    Article  PubMed  CAS  Google Scholar 

  • O’Donovan PA, Vandekerckhove P, Lilford RJ, Hughes E. Treatment of male infertility: is it effective? Review and meta-analyses of published randomized controlled trials. Hum Reprod 1993;8:1209–22

    PubMed  CAS  Google Scholar 

  • Reijo R, Lee TY, Salo P, Alagappan R, Brown LG, Rosenberg M, Rozen S, Jaffe T, Straus D, Hovatta O, de la Chapelle A, Silber S, Page DC. Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nature Genetics 1995;10:383–93

    Article  PubMed  CAS  Google Scholar 

  • Tiemessen CHJ, Evers JLH, Bots RSGM. Tight-fitting underwear and sperm quality. Lancet 1996;347:1844–5

    Article  PubMed  CAS  Google Scholar 

  • Tournaye H, Camus M, Goossens A, Liu J, Nagy P, Silber S, Van Steirteghem AC, Devroey P. Recent concepts in the management of infertility because of non-obstructive azoospermia. Hum Reprod 1995;10suppl 1:115–9

    PubMed  Google Scholar 

  • Vogt P, Chandley AC, Hargreave TB, Keil R, Ma K, Sharkey A. Microdeletions in interval 6 of the Y chromosome of males with idiopathic sterility point to disruption of AZF, a human spermatogenesis gene. Hum Genet 1992;89:491–6

    Article  PubMed  CAS  Google Scholar 

  • Watkins W, Nieto N, Bourne H, Wutthiphan B, Speirs A, Baker HWG. Testicular and epididymal sperm in a microinjection program: methods of retrieval and results. Fertil Steril 1997;67:527–35

    Article  PubMed  CAS  Google Scholar 

  • Wilton LJ, Temple-Smith PD, Baker HWG, de Kretser DM. Human male infertility caused by degeneration and death of sperm in the epididymis. Fertil Steril 1988;49:1052–8 World Health Organization Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction. 4th Ed Cambridge University Press (in press) 1999

    PubMed  CAS  Google Scholar 

  • Zorgniotti AW & Sealfon AI. Measurement of intrascrotal temperature in normal and subfertile men. J Reprod Fertil 1988;82:563–6

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Royal Women’s Hospital, University of Melbourne, Melbourne, Victoria, Australia

    Gordon W. H. Baker

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  1. Gordon W. H. Baker
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Editors and Affiliations

  1. Harbor-UCLA Medical Center, Torrance, California, USA

    Christina Wang M.D.

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© 1999 Kluwer Academic Publishers

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Baker, G.W.H. (1999). Modern Management of Male Infertility. In: Wang, C. (eds) Male Reproductive Function. Mineralogical Society Series, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38145-9_14

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  • DOI: https://doi.org/10.1007/978-0-585-38145-9_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8520-2

  • Online ISBN: 978-0-585-38145-9

  • eBook Packages: Springer Book Archive

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