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The Genetics of Male Infertility

  • S. Bhasin
  • W. E. Taylor
  • C. Mallidis
  • B. Salehian
  • I. Sinha
  • M. Limbo
  • K. Ma
Part of the Mineralogical Society Series book series (ENDO, volume 5)

Abstract

While a multitude of acquired causes can impair spermatogenesis, there is reason to believe that a genetic basis exists in a majority of infertile men (Bhasin et al, 1994; De Kretser et al, 1972; Lamb and Niederberger, 1994; Jaffe and Oates, 1994; Skakkebaek et al, 1994). The occurrence of these genetic defects in infertile men has significant implications for assisted reproductive technologies, particularly intracytoplasmic sperm injection (ICSI) (Bhasin et al, 1994). Because intracytoplasmic sperm injection may allow partners of these infertile men to become pregnant, it is possible that these genetic defects may be transmitted to the male offspring. This raises issues of informed consent and ethical concerns. Similarly, the widespread use of assisted reproductive techniques to induce pregnancy may result in accumulation of genetic defects in the population; these defects would have been otherwise weeded out because of infertility. Substantial prevalence of Y deletions and other known and unknown genetic defects in infertile men and the potential risk of transmitting this genetic disorder to their offspring provide a compelling rationale for genetic screening of infertile men prior to ICSI. The couples undergoing ICSI should be counseled about the potential risk of transmitting this genetic disorder to the offspring. Long term monitoring of ICSI babies for genetic disorders including Y deletions is warranted.

Keywords

Germ Cell Follicle Stimulate Hormone Sertoli Cell Seminiferous Tubule Male Infertility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • S. Bhasin
    • 1
  • W. E. Taylor
    • 1
  • C. Mallidis
    • 1
  • B. Salehian
    • 1
  • I. Sinha
    • 1
  • M. Limbo
    • 1
  • K. Ma
    • 1
  1. 1.Charles R. Drew University of Medicine and ScienceLos Angeles

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