Endocrine Regulation of Male Reproduction

  • I. T. Huhtaniemi
Part of the Mineralogical Society Series book series (ENDO, volume 5)


The two functions of the testis are androgen production and spermatogenesis. The key role in the regulation of these functions is played by the two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as supported by a vast number of experimental and clinical data. These facts have recently been corroborated by findings on patients with inactivating mutations of the gonadotropin or gonadotropin receptor genes, and by transgenic and knock-out mouse models. Besides gonadotropins, a number of other hormones contribute to testicular regulation, and there is a plethora of paracrine and autocrine regulatory effects between and within the different testicular cell compartments (see Chapter 3). However, the physiological role of these regulatory mechanisms, so far mostly demonstrated in vitro, has only recently started emerging.


Luteinizing Hormone Sertoli Cell Leydig Cell Endocrine Regulation GnRH Neuron 
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© Kluwer Academic Publishers 1999

Authors and Affiliations

  • I. T. Huhtaniemi
    • 1
  1. 1.University of TurkuTurkuFinland

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