Cell cycle regulation and apoptotic cell death

  • Lothar Jahn
  • Harald Bär
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)


The number of cells in any cellular biological system is determined by the balance of cell proliferation and cell death. Changes result in tissue growth or atrophy. The control of this equilibrium is crucial for the developing and the fully differentiated organism. Morphogenesis, gain and maintenance of organ function and response to various types of cell stress require mechanisms tightly controlling this equilibrium. The development of digits and the reorganisation and loss of thymic cells during mammalian development, the remodelling of bones in response to various forces are examples for processes depending on major shifts of this equilibrium that must be regulated extraordinarily accurate. An imbalance of cell proliferation and cell death may be the primary cause of diseases. Moreover, the seize of organs, animals and human beings eventually are determined by this balance.


Cell Cycle Regulation Cell Cycle Control Cyclin Dependent Kinase Inhibitor Cell Cycle Regulate Protein Cardiac Biology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Lothar Jahn
    • 1
  • Harald Bär
    • 1
  1. 1.Ruprecht-Karls-Universität HeidelbergHeidelbergGermany

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