Cell cycle regulation and apoptotic cell death
The number of cells in any cellular biological system is determined by the balance of cell proliferation and cell death. Changes result in tissue growth or atrophy. The control of this equilibrium is crucial for the developing and the fully differentiated organism. Morphogenesis, gain and maintenance of organ function and response to various types of cell stress require mechanisms tightly controlling this equilibrium. The development of digits and the reorganisation and loss of thymic cells during mammalian development, the remodelling of bones in response to various forces are examples for processes depending on major shifts of this equilibrium that must be regulated extraordinarily accurate. An imbalance of cell proliferation and cell death may be the primary cause of diseases. Moreover, the seize of organs, animals and human beings eventually are determined by this balance.
KeywordsCell Cycle Regulation Cell Cycle Control Cyclin Dependent Kinase Inhibitor Cell Cycle Regulate Protein Cardiac Biology
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- 3.Hata S, Kouchi H, Suzuka K Ishii T. Isolation and characterization of cDNA clones for plant cyclins. EMBOJ. 1991; 10, 2681–2688.Google Scholar
- 10.Gu Y, Rosenblatt J, Morgan D. Cell cycle regulation of CDK2 activity by phosphorylation of Thrl60 and Tyr15. EMBOJ. 1992; 11, 3995–4005.Google Scholar
- 31.Kano A, Watanabe Y, Takeda N, Aizawa S, Akaike T. Analysis of IFN-gamma-induced cell cycle arrest and cell death in hepatocytes. J Biochem (Tokyo). 1997; 121:677–683.Google Scholar
- 39.Chen WD, Otterson GA, Lipkowitz S, Khleif SN, Coxon AB, Kaye FJ. Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding. Qncogem. 1997; 14:1243–1248.Google Scholar