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BCL-2 family members and mitochondria

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Apoptosis in Cardiac Biology

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 5))

Abstract

The process of apoptosis is often subdivided into three phases: the initiation phase which depends on the apoptosis stimulus, the effector phase which underlies regulation of intracellular signaling and the degradation phase which is common to all forms of apoptosis and which is beyond regulation (1). The Bcl-2 family represents one of the most important families of apoptosis relevant proteins acting in the effector phase of apoptosis. In most cases of programmed cell death Bcl-2 proteins influence the decision of a cell to survive or to die. This review will focus on the basic molecular function of Bcl-2 family members in apoptosis as well as the interplay of some of the bcl-2 members with mitochondria in the context of mitochondrial permeability transition and mitochondrial release of apoptogenic factors.

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  1. Universität Regensburg, Regensburg, Germany

    Klaus Schlottmann M.D. & Jürgen Schölmerich M.D.

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    Heribert Schunkert  & G. A. J. Riegger  & 

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Schlottmann, K., Schölmerich, J. (2000). BCL-2 family members and mitochondria. In: Schunkert, H., Riegger, G.A.J. (eds) Apoptosis in Cardiac Biology. Basic Science for the Cardiologist, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38143-5_5

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  • DOI: https://doi.org/10.1007/978-0-585-38143-5_5

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