Oncogenes and p53

  • Franz Kohlhuber
  • Dirk Eick
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)


The tumor suppressor gene p53 plays a major role in cellular stress response and has been found to be mutated or deleted in more than half of all human tumors. Many signal pathways and factors contribute to control the action of p53. Here we will focus on the control function of p53 after cell cycle activation by oncogenes.


Simian Virus Cell Cycle Activation Ubiquitin Ligase Activity Myocyte Apoptosis Transcriptional Activation Domain 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Franz Kohlhuber
    • 1
  • Dirk Eick
    • 1
  1. 1.GSF-ForschungszentrumMünchenGermany

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