Reactive oxygen species and apoptosis
There is an increasing body of evidence suggesting an important role of apoptosis for cardiac development and diseases. This is based on the observation that in animals and humans the ontogenesis of the normal heart is characterized by the appearance of apoptosis peaking in the perinatal period (1) and in specific regions of the heart (2). Furthermore, myocardial infarction has been shown to be associated with apoptosis in rats (3) and humans (4). Additionally, apoptosis is evident in the heart of patients suffering from certain conductance disturbances (2) as well as in human cardiomyopathies, including the arrhythmogenic right ventricular dysplesia (5) and dilated cardiomyopathy (6). Those studies are important not only because of their proof of apoptotic cell death in yet another organ, but particularly because they let us understand that the capacity for apoptotic cell death exists in both mitotic cells and in post-mitotic cells. However, only little information exists regarding the identification of stimuli responsible for the induction of apoptosis in the heart.
KeywordsReactive Oxygen Species Vascular Smooth Muscle Cell Cardiac Fibroblast Arrhythmogenic Right Ventricular Dysplasia VSMC Proliferation
Unable to display preview. Download preview PDF.
- 21.Bochaton Piallat ML, Gabbiani F, Redard M, Desmouliere A, Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. Am J Pathol. 1995; 146:1059–1064.Google Scholar
- 26.von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis, Circulation. 1999, 99:2934–2941.Google Scholar
- 30.Li PF, Dietz R, von Harsdorf R. Requirement for protein kinases C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation. 1999;100:in press.Google Scholar