Apoptosis in cardiac myocytes - Role of the renin-angiotensin-system
Apoptosis is considered as a form of physiological cell death, characterized by chromatin condensation, cytoplasmatic blebbing and DNA fragmentation. It plays a key role during development, homeostasis, and several diseases including cardiovascular disorders. Apoptosis occurs through the activation of a cell-intrinsic suicide program. The activation of the cell suicide program is regulated by many different signals that originate from both the intracellular and extracellular milieu ( 1 ). Experimental evidence suggests that exaggerated apoptosis may account for the loss of cardiomyocytes in heart failure. Furthermore, several factors intrinsic and extrinsic to the cardiomyocytes have been suggested as potential candidates to trigger apoptosis.
KeywordsCardiac Myocytes Renin Angiotensin System Cardiomyocyte Apoptosis Myocyte Apoptosis Chronic Pressure Overload
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