Advertisement

Regulation of apoptosis by CD 137

  • Herbert Schwarz
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)

Abstract

CD 137 (ILA/4-1BB) is a member of the TNF receptor family and was identified in screens for genes induced upon lymphocyte activation (1,2). CD 137 is expressed by activated lymphocytes and expression its is strictly activation dependent (3). Expression of CD137 can also be induced in non-immune cells, like chondrocytes (4). In vivo, the highest expression of CD137 has been found in blood vessel walls. Since expresssion and function of CD 137 are not yet investigated in the heart, lymphocytes serve as a model. The gene for human CD 137 resides on chromosome Ip36, and this chromosomal region is associated with mutations in several malignancies (6).

Keywords

Tissue Culture Plate Peripheral Monocyte Primary Monocyte Chromosome Lp36 Cardiac Biology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Smith CA, Farrah T, Goodwin RG. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death. Cell 1994;76;959.PubMedCrossRefGoogle Scholar
  2. 2.
    Lotz M, Setareh M, Von Kempis J, Schwarz H. The nerve growth factor/tumor necrosis factor receptor family. J Leukoc Biol 1996;60:1.PubMedGoogle Scholar
  3. 3.
    Schwarz H, Valbracht J, Tuckwell J, Kempis J, Lotz M. ILA, the human 4-1BB homologue is inducible in lymphoid and other cell lines. Blood 1995;85:1043.PubMedGoogle Scholar
  4. 4.
    von Kempis J, Schwarz H, Lotz M. Differentiation-dependent and stimulus-specific expression of ILA, the human 4-lBB-homologue, in cells of mesenchymal origin. Osteoarthritis Cartilage 1997;5:394–406.CrossRefGoogle Scholar
  5. 5.
    Schwarz H, Arden K, Lotz M. CD137, a member of the tumor necrosis factor receptor family is located on chromosome Ip36, in a cluster of related genes, and colocalizes with several malignancies. Biochem Biophys Res Comm 1997;235:699.PubMedCrossRefGoogle Scholar
  6. 6.
    Michel J, Langstein J, Hofstädter F, Schwarz H. A soluble form of CD137 (ILA/4-IBB) is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis. Eur J Immunol 1998; 28:290.PubMedCrossRefGoogle Scholar
  7. 7.
    Alderson MR, Smith CA, Tough TW, Davis-Smith T, Armitage RJ, Falk B, Roux E, Baker E, Sutherland GR, Din WS, Goodwin RG. Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 1994;24:2219.PubMedCrossRefGoogle Scholar
  8. 8.
    Pollok KE, Kim YJ, Zhou Z, Hurtado J, Kim KK, Pickard RT Kwon BS. (1993) Inducible T cell antigen 4-1BB. Analysis of expression and function. J Immunol 1993;150:771.PubMedGoogle Scholar
  9. 9.
    Schwarz H, Blanco F, Valbracht J, Kempis J, Lotz M. ILA, A member of the human NGF/TNF receptor family regulates T lymphocyte proliferation and survival. Blood 1996;87:2839.PubMedGoogle Scholar
  10. 10.
    Debenedette MA, Shahinian A, Mak TW, Watts, TH. Costimulation of CD28-T lymphocytes by 4-1BB ligand. J Immunol 1997;158:551.PubMedGoogle Scholar
  11. 11.
    Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, Mittler RS, Chen L. Monoclonal antibodies against 4-IBB T cell activation molecule eradicate established tumors. Nat Med 1997;3:682.PubMedCrossRefGoogle Scholar
  12. 12.
    Beutler B, van Huffel C. Unraveling function in the TNF ligand and receptor families. Science. 1994;264:667–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Ohshima Y, Tanaka Y, Tozawa H, Takahashi Y, Maliszewski C, Delespesse G. Expression and function of OX40 ligand on human dendritic cells. J Immunol 1997; 159:3838–48.PubMedGoogle Scholar
  14. 14.
    Wiley SR, Goodwin RG, Smith CA. Reverse signaling via CD30 ligand. J Immunol 1996;15:157:3635–9Google Scholar
  15. 15.
    Suzuki I, Fink PJ. Maximal proliferation of cytotoxic T lymphocytes requires reverse signaling through Fas ligand. J Exp Med 1998; 187:123–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989;7:625.PubMedGoogle Scholar
  17. 17.
    Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991;66:233.PubMedCrossRefGoogle Scholar
  18. 18.
    Oehm A, Behrmann I, Falk W, Pawlita M, Maier G, Klas C, Li-Weber M, Richards S, Dhein J, Trauth BC, et-al. (1992) Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. J Biol Chem 1992;267:10709.PubMedGoogle Scholar
  19. 19.
    Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen, DE Induction of apoptosis by the low-affinity NGF receptor. Science 1993;261:345.PubMedCrossRefGoogle Scholar
  20. 20.
    Langstein J, Michel, Fritsche J, Kreutz M, Andreesen R, Schwarz H. CD 137, (ILA/4-IBB), a member of the TNF receptor family regulates monocyte activation via reverse signaling. J Immunol 1998, 160:2488–2494.PubMedGoogle Scholar
  21. 21.
    Brugger W, Kreutz M, Andreesen R. Macrophage colony-stimulating factor is required for human monocyte survival and acts as a cofactor for their terminal differentiation to macrophages in vitro. J Leukoc Biol 1991;49:483–488.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Herbert Schwarz
    • 1
  1. 1.Universität RegensburgRegensburgGermany

Personalised recommendations