Regulation of apoptosis by CD 137
CD 137 (ILA/4-1BB) is a member of the TNF receptor family and was identified in screens for genes induced upon lymphocyte activation (1,2). CD 137 is expressed by activated lymphocytes and expression its is strictly activation dependent (3). Expression of CD137 can also be induced in non-immune cells, like chondrocytes (4). In vivo, the highest expression of CD137 has been found in blood vessel walls. Since expresssion and function of CD 137 are not yet investigated in the heart, lymphocytes serve as a model. The gene for human CD 137 resides on chromosome Ip36, and this chromosomal region is associated with mutations in several malignancies (6).
KeywordsTissue Culture Plate Peripheral Monocyte Primary Monocyte Chromosome Lp36 Cardiac Biology
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