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Apoptosis in myocardial infarction

  • Andreas V. Sigel
  • Günter A. J. Riegger
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)

Abstract

Accumulating evidence suggests that programmed cell death plays an important role in myocardial infarction. The occurrence of programmed cell death has clearly been shown in several clinical (1,2,3) and experimental settings involving myocardial injury. Experimental data in vivo and in vitro suggest that cardiomyocytes are able to undergo apoptosis during hypoxia (4,5), hypoxia-reoxygenation (6,7), myocardial infarction (8,9), ischemia-reperfusion (10,11), and heart failure (12,13). Based on these studies the present concept of myocardial injury attributes the major portion of cell loss during cardiac ischemia and reperfusion to primary necrosis (14,15). However, based on the observation that apoptosis can be the early and predominant form of cell death in infarcted human myocardium, the possibility of apoptosis as inducer of secondary necrosis has already been raised (9,16). Thus, investigating the role of programmed cell death in myocardial infarction as well as documenting its underlying mechanisms may lead to new therapeutic strategies to prevent serious cell loss following ischemia and reperfusion.

Keywords

Myocardial Infarction Programme Cell Death Cardiac Myocytes Cardiomyocyte Apoptosis Chronic Congestive Heart Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Andreas V. Sigel
    • 1
  • Günter A. J. Riegger
    • 1
  1. 1.Universität RegensburgRegensburgGermany

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