Apoptosis and cell cycle in endothelial cells

  • Ioakim Spyridopoulos
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)


Apoptosis is an active process of cell death that occurs both under physiologic and pathophysiologic conditions. Specifically, apoptosis has been involved in vasculogenesis and atherosclerosis, inflammation, as well as wound healing, respectively. Its hallmark is the cleavage of genomic DNA into nucleosomal fragments of 180 bp (1). Although it has not been established to what extent endothelial cell death occurs in vivo, there is increasing evidence that endothelium may become apoptotic in various disease states.


Endothelial Cell Vascular Endothelial Growth Factor Nitric Oxide Human Umbilical Vein Endothelial Cell Human Endothelial Cell 
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© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Ioakim Spyridopoulos
    • 1
  1. 1.Universität TübingenTübingenGermany

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