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Death receptors and their ligands

  • Jürgen Holtz
  • Dorothea Darmer
Part of the Basic Science for the Cardiologist book series (BASC, volume 5)

Abstract

The identification and description of an intrinsic program of regulated cellular suicide or apoptosis was originally obtained from morphological analyses in developmental biology (76, 77). This program exists in all multicellular organisms, and genetic analyses in the nematode Caenorhabditis elegans identified three ced-genes (for C. elegans death) as basal, highly conserved components of this program, see (39, 57). In mammals, several structural and functional homologs of these ced-encoded proteins are involved in the apoptosis regulating complex formation at the outer mitochondrial membrane (Fig. 1), the apoptosome (56, 124), such as Apaf-1 (for “apoptosis protease activating factor”) or proteins of the Bcl-2 family (see chapter I.2.2). Another important discovery from C. elegans genetics was the identification of interleukin-lß-converting enzyme (ICE or caspase-1) as a functional homolog of the ced-3 gene product. This discovery triggered the identification of a whole cascade of caspases (for “cysteine-containing aspartic acid proteases”, see chapter I.3.1). This cascade is involved in the execution phase of apoptosis (164), and one source for activating the cascade is the mitochondrial apoptosome (Fig. 1).

Keywords

Tumor Necrosis Factor Death Receptor Tumor Necrosis Factor Receptor Death Domain Trail Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jürgen Holtz
    • 1
  • Dorothea Darmer
    • 1
  1. 1.Martin-Luther-Universität Halle-WittenbergHalle/SaaleGermany

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