Risks of recurrence of posttransplant lymphoproliferative disease, Hodgkin’s disease or Kaposi’s sarcoma after retransplantation

  • Israel Penn
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 29)


Lymphomas and lymphoproliferations comprise 24% of posttransplant malignancies and Kaposi’s sarcoma (KS) 6%, if non-melanoma skin cancers and in situ carcinomas of the uterine cervix are excluded, as they are from most studies of patterns of malignancy [1]. A gratifying feature is that following treatment 41% of lymphomas and 36% of KS undergo complete remission. In some patients a complication of such therapy is loss of the allograft, which may necessitate retransplantation. A question that arises is whether retransplan-tation, with reinstitution of full dose immunosuppressive therapy will precipitate recurrence of the neoplasm. The current study examined the data accumulated by the Cincinnati Transplant Tumor Registry (CTTR) from the fall of 1968 till May 1997 to address this question.


Autologous Bone Marrow Transplantation Smooth Muscle Tumor Kidney Allograft Renal Allograft Recipient Liver Allograft 
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© Kluwer Academic Publishers 1997

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  • Israel Penn

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