Antibody screening and crossmatching in retransplantation

  • Philip A. Dyer
  • Susan Martin
  • Judith Worthington
  • Stephen Sheldon
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 29)


Classical immunological dogma stipulates that reexposure to antigen results in an immediate and forceful response by the adaptive immune system. In the context of organ retransplantation this response is influenced by several factors, including antibody specificity of the primary response [1], affinity and isotype of preformed antibody, dose and immunogenicity of the antigen, immune responsiveness and health of the recipient. The pioneering work of Kissmeyer-Nielsen in Europe and Terasaki in the USA in the mid 1960s established that kidney transplants could be rejected hyperacutely by thrombosis of the transplant due to binding of preformed recipient antibody to donor antigen. It is now accepted that the most frequent target antigens in such instances are HLA antigens, coded for by the class I (HLA-A, -B, -Cw) or class II (HLA-DR,-DQ) genes of the major histocompatibility complex. Primary sensitization in transplant recipients usually occurs by one of three routes: blood transfusions, pregnancy and organ transplantation [2].


Antibody Screening Potential Recipient Thoracic Organ Mismatched Antigen Positive Crossmatch 
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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Philip A. Dyer
  • Susan Martin
  • Judith Worthington
  • Stephen Sheldon

There are no affiliations available

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