Tolerance and cytokine profiles in sensitized transplant recipients
The immediate and fulminant rejection of human renal allografts in sensitized recipients was first described more than 30 years ago . The process of hyperacute rejection, occurring within minutes or hours after revascularization, is thought to be primarily mediated by pre-existing anti-donor antibodies (Abs) . That it has become rare in recent years is primarily ascribed to improved crossmatching techniques . However, at present, over 20% of patients with end-stage renal disease on waiting transplant lists are considered highly sensitized. Apart from prior failed allografts, this may result from blood transfusions or pregnancies. These highly sensitized patients experience an increased rate of graft rejection, compared to unsensitized individuals, which is often irreversible and unresponsive to currently used immunosuppressive therapy.
KeywordsAllograft Rejection Graft Rejection Cardiac Allograft Transplantation Tolerance Hyperacute Rejection
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- 6.Hancock W, DiStefano R, Braun P, Schweizer RT, Tilney NL, Kupiec-Weglinski JW. Cyclosporine and anti-interleukin 2 receptor monoclonal antibody therapy suppress accelerated rejection of rat cardiac allografts through different effector mechanisms. Transplantation 1990; 49: 416–421.PubMedCrossRefGoogle Scholar
- 8.Hancock WW, Bach FH. The immunopathology of discordant xenograft rejection. Xeno 1994; 2: 68–74.Google Scholar