Molecular Determinats of the T Wave

  • Michael R. Rosen
Part of the Basic Science for the Cardiologist book series (BASC, volume 2)


The last two decades have seen an impressive increment in our understanding of the determinants of cardiac electrical activity, as molecular and genetic techniques applied initially to bacteria, yeast and drosophila have been used to explore the structure - function relationships of mammalian ion channels. A major asset in these studies has been the pattern of conservation that characterizes so many processes in nature; i.e., the ion channels studied molecularly and biophysically in less complex life forms have a good deal of homology with channels in mammalian heart. These points of similarity have facilitated our understanding of the physiology and the structure of the channels and - as a result - are providing new directions for exploring pathophysiology and developing therapy.


Action Potential Duration Ventricular Pace Transient Outward Current Cardiac Sodium Channel Idiopathic Ventricular Fibrillation 
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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Michael R. Rosen
    • 1
  1. 1.College of Physicians and Surgeons of Columbia UniversityUSA

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