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Physiologic and Pathophysiologic Effects of Angiotensin in the Heart and Vessel Wall

  • Chapter
Molecular Cardiology in Clinical Practice

Part of the book series: Basic Science for the Cardiologist ((BASC,volume 2))

Abstract

Angiotensin II (Ang II) exerts a majority of its known cardiovascular activities through the AT1 receptor. This receptor is a member of the 7-transmembrane superfamily and it exerts its actions via coupling to various G-proteins. Its downstream effectors include adenylate-cyclase, various phospholipases and ion channels. Moreover, various tyrosine kinase pathways have been reported to be activated by the AT1 receptor which result in the stimulation of the early response genes controlling cell growth. This action has been observed in several cell lines including cardiac myocytes and vascular smooth muscle cells. Moreover, studies strongly implicate the renin angiotensin system in the initiation and progression of atherosclerosis. Therefore, blockade of this system should influence not only vascular tone but may also have dramatic effects on vascular and cardiac structure.

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  1. Brigham and Women’s Hospital, USA

    Richard E. Pratt Ph.D.

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  1. Richard E. Pratt Ph.D.
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  1. Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, USA

    Michael Sanders  & John B. Kostis  & 

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© 1999 Kluwer Academic Publishers

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Pratt, R.E. (1999). Physiologic and Pathophysiologic Effects of Angiotensin in the Heart and Vessel Wall. In: Sanders, M., Kostis, J.B. (eds) Molecular Cardiology in Clinical Practice. Basic Science for the Cardiologist, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-38141-1_6

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  • DOI: https://doi.org/10.1007/978-0-585-38141-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-8602-5

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