Novel Mechanisms of Estrogen Action
Estrogen action has long been thought to be mediated via one unique estrogen receptor. This receptor was originally discovered by Elwood Jensen who managed to synthesize estrogens with sufficiently high specific radioactivity to be used as tracers for the receptor . Utilizing these radioligands Jensen could first show that estrogen target tissues like the uterus and vagina displayed a specific retention of radioactivity following administration of radiolabelled estrogens to whole animals. Later on it was demonstrated that this retention was due to the presence in these target tissues of a specific protein binding the radioligands with high affinity and low capacity. After the introduction of the technique of density gradient centrifugation to monitor the behavior of the estrogen receptor, these original contributions opened a new science on the characteristics of the estrogen receptor as well as somewhat later other members of the steroid receptor family.
KeywordsEstrogen Receptor Glucocorticoid Receptor Estrogen Action Mineralocorticoid Receptor Urogenital Tract
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- 1.Jensen EV, Jacobson HI. Basic guides to the mechanism of estrogen action. Recent Progr Horm Res 1962;18:387–414.Google Scholar
- 6.Yamamoto KR, Payvar F, Firestone GL, et al. Biological activity of cloned mammary tumor virus DNA fragments that bind purified glucocorticoid receptor protein in vitro. In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLVII, Cold Spring Harbor Laboratory, 1983:977–84.Google Scholar