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The Menopause, Sex Hormones, and Rheumatic Disease

  • Gerard Hall
Part of the Medical Science Symposia Series book series (MSSS, volume 13)

Abstract

The potential association between menopause, sex hormones, and rheumatic disorders has long been alluded to. In the early nineteenth century Haygarth noted the “nodosities” of joints that occurred at the menopause and Weil, in 1928, pointed to the inevitability of arthritis following female castration. Many of the comprehensive studies of symptoms seen in perimenopausal women cite joint pains as one of the most frequently encountered complaints [1].

Keywords

Rheumatoid Arthritis Systemic Lupus Erythematosus Hormone Replacement Therapy Carpal Tunnel Syndrome Oral Contraceptive Pill 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Neugarten BL, Kraines RJ. Menopausal symptoms in women of various ages. Psychom Med 1965;27:266–73.Google Scholar
  2. 2.
    Hall GM, Spector TD, Studd JWW. Carpal tunnel syndrome and hormone replacement therapy. Br Med J 1992;304:382.Google Scholar
  3. 3.
    Hassager C, Christiansen C. Estrogen/gestagen therapy changes soft tissue body composition in postmcnopausal women. Metabolism 1989;38:662–65.PubMedCrossRefGoogle Scholar
  4. 4.
    Goemare S, Ackerman C, Goethals K, et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol 1990;17:1620.Google Scholar
  5. 5.
    Spector TD, Hochberg MC. The protective effect of the oral contraceptive pill on rheumatoid arthritis: An overview of the analytic epidemiological studies using meta-analysis. J Clin Epidemiology 1990;43:1221.CrossRefGoogle Scholar
  6. 6.
    Rhodes K, Markham RL, Maxwell PM, Monk-Jones NE. Immunoglobulins and the X chromosome. Br Med J 1969;3:439.PubMedGoogle Scholar
  7. 7.
    Buckley CE, Dorsey FC. Serum immunoglobulin levels throughout the lifespan of healthy man. Ann Intern Med 1971;75:673.PubMedGoogle Scholar
  8. 8.
    Graff RJ, Lappe MA, Snell GD. The influence of the gonads and adrenal glands on the immune response to skin grafts. Transplantation 1969;7:105.PubMedGoogle Scholar
  9. 9.
    Goble FC, Konopka EA. Sex as a factor in infectious disease. Trans NY Acad Sci 1971;35: 325.Google Scholar
  10. 10.
    Ansar Ahmed S, Dauphinee MJ, Talal N. Effects of short-term administration on normal and autoimmune mice. J Immunol 1985;134. 204.PubMedGoogle Scholar
  11. 11.
    Paavonen T, Anderson LC, Adlercreutz H. Sex hormone regulation of in vitro immune response. Estradiol enhances B-cell maturation via inhibition of suppressor T-cells in pokeweed-mitogen stimulated cultures. J Exp Med 1985;154:1935.CrossRefGoogle Scholar
  12. 12.
    Blazkovec AA, Orsini MW. Ontogenetic aspects of sexual dimorphism and the primary immune response to sheep erythrocytes in hamster from pre-puberty through senescence. International Archives of Allergy and Applied Immunology 1976;50:55.PubMedGoogle Scholar
  13. 13.
    Grossman CJ. Regulation of the immune system by sex steroids. Endocr Rev 1984;5:435.PubMedGoogle Scholar
  14. 14.
    Pacifici R, Rifas L, McCracken R. Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin-1 release. Proc Natl Acad Sci 1989;86:2938.CrossRefGoogle Scholar
  15. 15.
    Hall G, Perry L, Spector T. Depressed levels of dehydroepiandrosterone sulphate in postmenopausal rheumatoid arthritis but no relationship with axial bone density. Ann Rheum Dis 1993;52:211.PubMedGoogle Scholar
  16. 16.
    Masi AT, Catterton RT, Comstock GW, Malamet RL, Hochberg MC. Decreased serum dehydroepiandrosterone sulfate levels before onset of RA in younger premenopausal women: A controlled prospective study. Arthritis Rheum 1994;37(Suppl.):S315.Google Scholar
  17. 17.
    Cutolo M, Accardo S, Villagio B, et al. Evidence for the presence of androgen receptors in the synovial tissue of rheumatoid arthritis patients and healthy controls. Arthritis Rheum 1992;35: 345.CrossRefGoogle Scholar
  18. 18.
    Cutolo M, Accerdo S, Villagio B, et al. Presence of estrogen binding sites on macrophage-like synoviocytes and CD8+, CD29+, CD45RO+ T-lymphocytes in normal and rheumatoid synovium. Arthritis Rheum 1993;36:1087.PubMedCrossRefGoogle Scholar
  19. 19.
    Holmdahl R, Jansson L, Anderson M. Female sex hormones suppress development of collagen induced arthritis in mice. Arthritis Rheum 1986;29:1501.PubMedCrossRefGoogle Scholar
  20. 20.
    Mattson R, Mattson A, Holmdahl R, Whyte A, Rook GA. Maintained pregnancy levels of oestrogen afford complete protection from post-partum exacerbation of collagen induced arthritis. Clin Exp Immunol 1991;85:41.CrossRefGoogle Scholar
  21. 21.
    Hall GM, Daniels M, Huskisson EC, Spector TD. A randomized controlled trial of hormone replacement therapy in postmenopausal rheumatoid arthritis. Ann Rheum Dis 1994;.Google Scholar
  22. 22.
    MacDonald AG, Murphy EA, Capell HA, Bankowska UZ, Ralston SH. Effects of hormone replacement therapy in rheumatoid arthritis: A double blind placebo-controlled study. Ann Rheum Dis 1994;53:54.PubMedCrossRefGoogle Scholar
  23. 23.
    van den Brink HR, van Everdingen A, van Wijk MJG, Jacobs JWG, Bijlsma JWJ. Adjuvant estrogen therapy does not improve disease activity in postmenopausal patients with rheumatoid arthritis. Ann Rheum Dis 1993;52. 862.PubMedGoogle Scholar
  24. 24.
    Lobo RA, Goebelsmann U, Brenner P, Mischell D. The effects of estrogen on adrenal androgens in oophorectomized women. Am J Obstet Gynecol 1982; 42:471.Google Scholar
  25. 25.
    Vandenbroucke JP, Witteman JCM, Valkenburg HA, et al. Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. JAMA 1986;255:1299–1303.PubMedCrossRefGoogle Scholar
  26. 26.
    Spector T, Brennan P, Harris P, Studd J, Silman A. Does oestrogen replacement therapy protect against rheumatoid arthritis? J Rheumatol 1991;18(10):1473.PubMedGoogle Scholar
  27. 27.
    Spector T, Nandra D, Hart D, Doyle D. Is hormone replacement therapy protective for hand and knee osteoarthritis in women? Ann Rheum Dis 1997;56:432.PubMedCrossRefGoogle Scholar
  28. 28.
    Oliveria S, Felson D, Klein R, Reed J, Walker A. Estrogen replacement therapy and the development of osteoarthritis. Epidemiology 1996;7;415–19.PubMedCrossRefGoogle Scholar
  29. 29.
    van Vollenhoven R, Engleman E, McGuire J. An open study of dehydroepiandrosterone in systemic lupus erythematosus. Arthritis Rheum 1994;37:1305.PubMedCrossRefGoogle Scholar
  30. 30.
    Arden NK, Lloyd ME, Spector TD, Hughes GR. Safety of hormone replacement therapy in systemic lupus erythematosus. Lupus 1994; 3. 11–13.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1999

Authors and Affiliations

  • Gerard Hall

There are no affiliations available

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