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Breast Cancer and HRT: Collaborative Reanalysis of Data

  • Martin P. Vessey
Part of the Medical Science Symposia Series book series (MSSS, volume 13)

Abstract

Large numbers of epidemiological studies of the relationship between use of oral contraceptives and hormone replacement therapy (HRT) on the one hand and the risk of breast cancer on the other have been published over the past two decades. The results have generally been regarded as conflicting and difficult to interpret. Some years ago, Professor Valerie Beral (Director of the Imperial Cancer Research Fund Cancer Epidemiology Unit, Oxford, UK) decided that the best way forward would be to undertake a collaborative re-analysis of the studies. She and her team succeeded in gaining the support of almost all the investigators worldwide and in 1996 a collaborative re-analysis of the data on breast cancer and oral contraceptive use was published [1]. This was followed by a similar reanalysis concerning the data on breast cancer and hormone replacement therapy which appeared in 1997 [2]. The latter analysis is the subject of the present report.

Keywords

Breast Cancer Breast Cancer Risk Hormone Replacement Therapy Term Birth Missing Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 1996;347:1713–27.CrossRefGoogle Scholar
  2. 2.
    Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy. Collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 1997;350:1047–59.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1999

Authors and Affiliations

  • Martin P. Vessey

There are no affiliations available

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