Advertisement

Hormone Replacement Therapy and Breast Cancer Risk in High-Risk Subgroups

  • P. Sismondi
  • N. Biglia
  • M. Giai
  • R. Roagna
  • R. Ponzone
  • L. G. Sgro
  • M. Cozzarella
Part of the Medical Science Symposia Series book series (MSSS, volume 13)

Abstract

Epidemiologie studies have attempted to identify whether certain subgroups of postmenopausal women using hormone replacement therapy (HRT) are more susceptible to the effects of steroids in relation to breast cancer risk. Subgroups of interest include women with a family history of breast cancer, women with a history of benign breast disease (BBD), obese individuals, older hormone users, past users of oral contraceptives (OC), and women who consume alcohol.

Keywords

Breast Cancer Breast Cancer Risk Oral Contraceptive Hormone Replacement Therapy Estrogen Replacement Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Steinberg KK, Thacker SB, Smith SJ, et al. A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 1991;265:1985–90.PubMedCrossRefGoogle Scholar
  2. 2.
    Colditz GA, Egan KM, Stampfer MJ, et al. Hormone replacement therapy and risk of breast cancer: Results from epidemiologic studies. Am J Obstet Gynecol 1993;168:1473–80.PubMedGoogle Scholar
  3. 3.
    Brinton LA, Hoover R, Fraumeni JF Jr. Menopausal oestrogens and breast cancer risk: an expanded case-control study. Br J Cancer 1986;54:825–32.PubMedGoogle Scholar
  4. 4.
    Newcomb PA, Longnecker MP, Storer BE, et al. Long-term hormone replacement therapy and risk of breast cancer in post-menopausal women. Am J Epidemiol 1995;142:788–95.PubMedGoogle Scholar
  5. 5.
    Mills PK, Beeson WL, Phillips RL, et al. Prospective study of exogenous hormone use and breast cancer in Seventh-day Adventist. Cancer 1989;64:591–97.PubMedCrossRefGoogle Scholar
  6. 6.
    Palmer JL, Rosenberg L, Clarke EA, et al. Breast cancer risk after estrogen replacement therapy: Result from the Toronto breast cancer study. Am J Epidemiol 1991;134:1386–1401.PubMedGoogle Scholar
  7. 7.
    Colditz GA, Rosner BA, Speizer FE. Risk factors for breast cancer according to family history of breast cancer. J Natl Cancer Inst 1996;88:365–71.PubMedCrossRefGoogle Scholar
  8. 8.
    Sellers TA, Mink PJ, Cerhan JR, et al. The role of hormone replacement therapy in the risk for breast cancer and total mortality in women with a family history of breast cancer. Ann Int Med 1997;127:973–80.PubMedGoogle Scholar
  9. 9.
    Grodstein F, Stampfer MJ, Colditz GA, et al. Postmenopausal hormone therapy and mortality. N Engl J Med 1997;336:1769–75.PubMedCrossRefGoogle Scholar
  10. 10.
    Dupont WD, Page DL, Rogers LW, et al. Influence of exogenous estrogens, proliferative breast disease, and other variables on breast cancer risk. Cancer 1989;63:948–57.PubMedCrossRefGoogle Scholar
  11. 11.
    Hoover R, Glass A, Finkle WD, et al. Conjugated estrogens and breast cancer risk in women. J Natl Cancer Inst 1981;67:815–20.PubMedGoogle Scholar
  12. 12.
    Thomas DB, Persing JP, Hutchinson WB. Exogenous estrogens and other risk factors for breast cancer in women with benign breast disease. J Natl Cancer Inst 1982;69:1017–25.PubMedGoogle Scholar
  13. 13.
    Dupont WD, Page DL. Menopausal estrogen replacement therapy and breast cancer. Arch Intern Med 1991;151:67–72.PubMedCrossRefGoogle Scholar
  14. 14.
    Stanford J, Weiss N, Voigt L, et al. Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women. JAMA 1995;274:137–42.PubMedCrossRefGoogle Scholar
  15. 15.
    La Vecchia C, Negri E, Franceschi S, et al. Hormone replacement treatment and breast cancer risk: A cooperative Italian study. Br J Cancer 1995;72:244–48.PubMedGoogle Scholar
  16. 16.
    Foth D, Cline JM. Effects of estrogen monotherapy on breast tissue in the primate model. Zentralbl Gynacol 1997;119:607–10.Google Scholar
  17. 17.
    Brinton LA. Hormone replacement therapy and risk for breast cancer. Endocr Metab Clin North Am 1997;26:361–78.CrossRefGoogle Scholar
  18. 18.
    Collaborative Group of Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: Collaborative reanalysis of data from 51 epidemiological studies of 52705 women without breast cancer. Lancet 1997;350:1047–59.CrossRefGoogle Scholar
  19. 19.
    Wingo PA, Layde PM, Lee NC, et al. The risk of breast cancer in postmenopausal women who have used estrogen replacement therapy. JAMA 1987;257:209–15.PubMedCrossRefGoogle Scholar
  20. 20.
    Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. New Engl J Med 1995;332:1589–93.PubMedCrossRefGoogle Scholar
  21. 21.
    Tavani A, Braga C, La Vecchia C, et al. Hormone replacement treatment and breast cancer risk: An age-specific analysis. Cancer Epidemiol Biomark Prev 1997;6:11–14.Google Scholar
  22. 22.
    Pujol P, Galtier-Dereure F, Bringer J. Obesity and breast cancer risk. Hum Reprod 1997;12Suppl:116–25.PubMedGoogle Scholar
  23. 23.
    Colditz GA, Stampfer MJ, Willet WC, et al. Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses’ Health Study. Cancer Causes Control 1992;3:433–39.PubMedCrossRefGoogle Scholar
  24. 24.
    Harris RE, Namboodiri KK, Winder EL. Breast cancer risk: Effects of estrogen replacement therapy and body mass. J Natl Cancer Inst 1992;84:1575–82.PubMedCrossRefGoogle Scholar
  25. 25.
    Kaufman DW, Palmer JR, de Mouzon J, et al. Estrogen replacement therapy and the risk of breast cancer: Results from the case-control surveillance study. Am J Epidemiol 1991;134:1375–85.PubMedGoogle Scholar
  26. 26.
    Weinstein AL, Mahoney MC, Nasca PC, et al. Oestrogen replacement therapy and breast cancer risk: A case-control study. Int J Epidemiol 1993;22:781–89.PubMedCrossRefGoogle Scholar
  27. 27.
    Campagnoli C, Biglia N, Belforte P, et al. Post-menopausal breast cancer risk: Oral estrogen treatment and abdominal obesity induce opposite changes in possibly important biological variables. Eur J Gynaec Oncol 1992;13:139–54.Google Scholar
  28. 28.
    Campagnoli C, Biglia N, Peris C, Sismondi P. Potential impact on breast cancer risk of circulating insulin-like growth factor I modifications induced by oral HRT in menopause. Gynecoi Endocrinol 1995;9:67–74.CrossRefGoogle Scholar
  29. 29.
    Campagnoli C, Biglia N, Cantamessa C, et al. Insulin-like growth factor I (IGF-I) serum level modifications during transdermal estradiol treatment in postmenopausal women: A possible bimodal effect depending on basal IGF-I values. Gynecoi Endocrinol 1997; in press.Google Scholar
  30. 30.
    Longnecker MP. Alcoholic beverage consumption in relation to risk of breast cancer. Meta-analysis and review. Cancer Causes Control 1994;5:73–82.PubMedCrossRefGoogle Scholar
  31. 31.
    Smith-Warner SA, Spiegelman D, Yaun SS, et al. Alcohol and breast cancer in women: A pooled analysis of cohort studies. JAMA 1998;279:535–40.PubMedCrossRefGoogle Scholar
  32. 32.
    Thun MJ, Peto R, Lopez AD, et al. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N Engl J Med 1997;337:1705–14.PubMedCrossRefGoogle Scholar
  33. 33.
    Gapstur SM, Potter JD, Sellers TA, et al. Increased risk of breast cancer with alcohol consumption in postmenopausal women. Am J Epidemiol 1992;136:1221–31.PubMedGoogle Scholar
  34. 34.
    Colditz GA, Stampfer MJ, Willet WC, et al. Prospective study of estrogen replacement therapy and risk of breast cancer in postmenopausal women. JAMA 1990;264:2648–53.PubMedCrossRefGoogle Scholar
  35. 35.
    Ginsburg EL, Mello NK, Mendelson JH, et al. Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA 1996;276:1747–51.PubMedCrossRefGoogle Scholar
  36. 36.
    Zumoff B. Editorial: The critical role of alcohol consumption in determining the risk of breast cancer with postmenopausal estrogen administration. J Clin Endocrinol Metab 1997;82:1656–58.PubMedCrossRefGoogle Scholar
  37. 37.
    Schuunnan AG, van den Brandt PA, Goldbohm RA. Exogenous hormone use and the risk of postmenopausal breast cancer: Results from the Netherlands cohort study. Cancer Causes and Control 1995;6:416–24.CrossRefGoogle Scholar
  38. 38.
    Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53297 women with breast cancer and 100239 women without breast cancer from 54 epidemiological studies. Lancet 1996;347:1713–27.CrossRefGoogle Scholar
  39. 39.
    Sismondi P, Biglia N, Giai M, Campagnoli C. Hormone replacement therapy and breast cancer. Eur Menopause J 1996;3:227–31.Google Scholar

Copyright information

© Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1999

Authors and Affiliations

  • P. Sismondi
  • N. Biglia
  • M. Giai
  • R. Roagna
  • R. Ponzone
  • L. G. Sgro
  • M. Cozzarella

There are no affiliations available

Personalised recommendations