Abstract
Overweight and obesity are consistently related to the risk of three cancer sites: gallbladder, endometrium, and breast in postmenopausal women [1]. The relative risks are of the order of five for obese individuals as compared to leaner ones for gallbladder and endometrium, and about 1.5 for breast cancer. Still, since mortality rates from breast cancer are substantially higher than from gallbladder and endometrial neoplasms, the public health implications of elevated breast cancer risks in overweight individuals are probably greater than for any other neoplasm [2].
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References
Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chron Dis 1979;32:563–76.
La Vecchia C, Negri E. Public education on diet and cancer: Calories, weight and exercise. In: Public education on diet and cancer. Dordrecht: Kluwer, 1992: 91–9.
La Vecchia C, Negri E, D’Avanzo B, Boyle P. Risk factors for gallstone disease requiring surgery. Int J Epidemiol 1991;20:209–15.
La Vecchia C, Decarli A, Negri E, Parazzini F. Epidemiological aspects of diet and cancer: A summary review of case-control studies from northern Italy. Oncology 1988;45:364–70.
Whittemore AS, Paffenbarger RS Jr, Anderson K, Lee JF. Early precursors of site-specific cancers in college men and women. J Natl Cancer Inst 1985;74:43–51.
Goodman MT, Morgenstern H, Wynder EL. A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 1986;124:926–41.
Tavani A, La Vecchia C. Epidemiology of renal-cell carcinoma. J Nephrol 1997;10:93–106.
Doll R, Peto R. The causes of cancer: Quantitative estimates of avoidable risks of cancer in United States today. J Natl Cancer Inst 1981;66:1191–308.
Pagano R, La Vecchia C, Decarli A, Negri E, Franceschi S. Trends in overweight and obesity among Italian adults, 1983 through 1994. Am J Publ Health 1997;87:1869–70.
Tavani A, Negri E, D’Avanzo B, La Vecchia C. Body weight and risk of nonfatal acute myocardial infarction among women: A case-control study from northern Italy. Prev Med 1997;26:550–55.
Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG. “Hormonal” risk factors, “breast tissue age” and the age-incidence of breast cancer. Nature 1983;303:767–70.
Hunter DJ, Willett WC. Diet, body size, and breast cancer. Epidemiol Rev 1993;15:110–32.
Stoll BA. Breast cancer: The obesity connection. Br J Cancer 1994;69:799–801.
Hsieh C-C, Trichopoulos D, Katsouyanni K, Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: Associations and interactions in an international case-control study. Int J Cancer 1990;46:796–800.
Franceschi S, Favero A, La Vecchia C, et al. Body size indices and breast cancer risk before and after menopause. Int J Cancer 1996;67:181–86.
La Vecchia C, Negri E, Franceschi S, et al. Body mass index and post-menopausal breast cancer: An age-specific analysis. Br J Cancer 1997;75:441–44.
Day NE, Brown CC. Multistage models and primary prevention of cancer. J Natl Cancer Inst 1980;64:977–89.
Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 1995;332:1589–93.
La Vecchia C, Negri E, Franceschi S, et al. Hormone replacement treatment and breast cancer risk: A cooperative Italian study. Br J Cancer 1995;72:244–48.
Tavani A, Braga C, La Vecchia C, Negri E, Franceschi S. Hormone replacement treatment and breast cancer risk: An age-specific analysis. Cancer Epidemiol Biomarkers Prev 1997;6:11–14.
Henderson BE. Hormones as a cause of human cancer. In: Fortner JG, Rhoads JE, editors. Accomplishments in Cancer Research 1984 Prize Year. Philadelphia: Lippincott, 1985: 152–68.
Huang Z, Hankinson SE, Colditz GA, et al. Dual effects of weight and weight gain on breast cancer risk. JAMA 1997;278:1407–11.
Kelsey JL, Baron J. Weight and risk for breast cancer. JAMA 1997;278:1448–49.
Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 1985;122:904–14.
Mezzetti M, Ferraroni M, Decarli A, La Vecchia C, Benichou J. Software for attributable risk and confidence interval estimation in case-control studies. Comput Biomed Res 1996;29:63–75.
Parazzini F, La Vecchia C, Bocciolone L, Franceschi S. The epidemiology of endometrial cancer. Gynecol Oncol 1991;41:1–16.
La Vecchia C, Negri E, Franceschi S, Levi F. An epidemiological study of endometrial cancer, nutrition and health. Eur J Cancer Prev 1997;6:171–74.
Key TJA, Pike MC. The dose-effect relationship between unopposed estrogens and endometrial mitotic rate: Its central role in explaining and predicting endometrial-cancer risk. Br J Cancer 1988;57:205–12.
La Vecchia C, Franceschi S, Gallus G, et al. Estrogens and obesity as risk factors for endometrial cancer in Italy. Int J Epidemiol 1982;11:120–26.
La Vecchia C, Franceschi S, Decarli A, Gallus G, Tognoni G. Risk factors for endometrial cancer at different ages. J Natl Cancer Inst 1984;73:667–71.
La Vecchia C. HRT and the risk of neoplasms other than in the breast. Eur Menopause J 1996;3:232–36.
McDonald TW, Annegers JF, O’Fallon WM, Dockerty MB, Malkasian GD Jr, Kurland LT. Exogenous estrogen and endometrial carcinoma: Case-control and incidence study. Am J Obstet Gynecol 1977;127:572–80.
Parazzini F, Negri E, La Vecchia C, Bruzzi P, Decarli A. Population attributable risk for endometrial cancer in northern Italy. Eur J Cancer 1989;25:1451–56.
Goodman MT, Hankin JH, Wilkens LR, et al. Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 1997;57:5077–85.
Levi F, La Vecchia C, Negri E, Parazzini F, Franceschi S. Body mass at different ages and subsequent endometrial cancer risk. Int J Cancer 1992;50:567–71.
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© 1999 Kluwer Academic Publishers and Fondazione Giovanni Lorenzini
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La Vecchia, C. (1999). Breast and Female Genital Tract Neoplasms in Overweight Women. In: Women’s Health and Menopause. Medical Science Symposia Series, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-37973-9_32
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DOI: https://doi.org/10.1007/978-0-585-37973-9_32
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-5906-7
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