Management of the Late Menopause: Ultra Low-Dose Adjustive Estrogen Therapy
Women over 65 years of age do benefit from hormone therapy, but compliance is often poor because of estrogen-induced side effects and fear of breast cancer. Ultra low-dose estrogen therapy (ULET), adjusted to the need of the individual is effective in meeting various therapeutic goals while minimizing unacceptable side effects. The four main principles of ULET include: individualizing therapy by patient examination and selective testing; prescription of the lowest effective dose of a natural estrogen; choosing the route of administration based on the patient’s preference and medical need; adjusting the therapy over time by monitoring symptomatic and specific biologic end-point responses.
KeywordsBone Mineral Density Estrogen Therapy Endometrial Hyperplasia Lower Effective Dose Unacceptable Side Effect
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