Estrogen Complexes Contained in Conjugated Equine Estrogens (CEE): An Overview of Their Structure and Possible Effects on Target Tissue
The basic concept of estrogen action was established many years ago by pioneering studies by Drs. Elwood Jensen and Jack Gorski [1,2]. In this presentation, this model will be reviewed and it will be suggested that several modifications to this model are required, as well as to the way clinicians and scientists think about the mechanism of steroid hormone action. First, data will be presented which suggest the need to rethink how estrogens work and how they interact with the receptor. Secondly, additional data on a new component found within the conjugated equine estrogens (CEE) family will be presented. Third, some speculation about the newer mechanisms that are being explored which can change the way estrogens work will be presented.
KeywordsEstrogen Receptor Conjugate Equine Estrogen Receptor Conformation Human Estrogen Receptor Estrone Sulfate
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