Role of Estrogens in Dementing Illnesses: Hypotheses on the Biological Rationale
Epidemiological data  indicate that postmenopausal estrogen replacement therapy (ERT) may be associated with a reduced risk of Alzheimer’s disease (AD) and ERT may also improve the cognitive performance of AD affected women. Moreover epidemiological data  suggest a sex difference in the prevalence of AD. The decline in sex steroid levels during aging has been widely studied; the receptor distribution in brain mirrors the distribution of the neuropathological markers of AD, therefore it is possible that estrogen levels decay in postmenopause contributes to the exacerbation of molecular events taking place with aging, thus leading to the development of AD.
KeywordsAmyloid Precursor Protein Estrogen Replacement Therapy Nerve Growth Factor Receptor DEMENTING Illness Amyloid Precursor Protein Metabolism
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