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Menopause and Psychopharmacology: Signs, Symptoms, and Treatment

  • Linda S. Kahn
  • Uriel Halbreich
Part of the Medical Science Symposia Series book series (MSSS, volume 13)

Abstract

Approximately 30% of postmenopausal women in Western countries receive hormone replacement therapy (HRT), mostly utilizing estrogen and progesterone. This number is expected to substantially increase over the next 10 years.

Keywords

Postmenopausal Woman Hormone Replacement Therapy Estrogen Replacement Therapy Hormonal Replacement Therapy Norethisterone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Belchetz P. Hormonal treatment of postmenopausal women. N Engl J Med 1994;330:1062–71.PubMedCrossRefGoogle Scholar
  2. 2.
    Lindsay R. Why do oestrogens prevent bone loss? Baillieres Clin Obstet Gynaecol 1991;5: 837–52.PubMedCrossRefGoogle Scholar
  3. 3.
    Stampfer M, Colditz G, Willet W, et al. Postmenopausal estrogen therapy and cardiovascular disease: Ten-year follow-up from the Nurses Health Study. N Engl J Med 1991;325:756–62.PubMedCrossRefGoogle Scholar
  4. 4.
    American College of Obstetricians and Gynecologists. Hormonal replacement therapy. Technical Bulletin #166. Washington: American College of Obstetricians and Gynecologists, 1992.Google Scholar
  5. 5.
    Halbreich U. Role of estrogen in postmenopausal depression. Neurology 1997;48(Suppl.7): S16–S20.PubMedGoogle Scholar
  6. 6.
    McEwen BS, Alves SE, Bulloch K, et al. Ovarian steroids and the brain: Implications for cognition and aging. Neurology 1997;48(Suppl.7):S8–S15.PubMedGoogle Scholar
  7. 7.
    Schneider MA, Brotherton PL, Hailes J. The effect of exogenous oestrogens on depression in menopausal women. Med J Aust 1977;2:162–63.PubMedGoogle Scholar
  8. 8.
    Michael C, Kantor H, Shore H. Further psychometric evaluation of older women-the effect of estrogen administration. J Gerontol 1970;25:337–41.PubMedGoogle Scholar
  9. 9.
    Aylward M. Estrogens and plasma tryptophan levels in perimenopausal patients. In: Campbell S, editor. The management of the menopause and post-menopausal years. Baltimore, Maryland: University Park Press, 1976:135–47.Google Scholar
  10. 10.
    Furuhjelm M, Carlstrom K. Treatment of climacteric and postmenopausal women with 17-beta-oestradiol and norethisterone acetate. Acta Obstet Gynecol Scand 1977;56:351–61.PubMedCrossRefGoogle Scholar
  11. 11.
    Furuhjelm M, Fedor-Freybergh P. The influence of estrogens on the psyche in climacteric and post-menopausal women. In: van Keep PA, Albeaux M, Greenblatt R, editors. Consensus on menopause research. Baltimore, Maryland: University Press, 1976:84–93.Google Scholar
  12. 12.
    Ditkoff EC, Crary WG, Cristo M, Lobo R. Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 1991;78:991–95.PubMedGoogle Scholar
  13. 13.
    Best, NR, Rees MP, Barlow DH, Cowen PJ. Effect of estradiol implant on noradrenergic function and mood in menopausal subjects. Psychoneuroendocrinology 1992;17:87–93.PubMedCrossRefGoogle Scholar
  14. 14.
    Palinkas LA, Barrett-Connor E. Estrogen use and depressive symptoms in postmenopausal women. Obstet Gynecol 1992;80:30–36.PubMedGoogle Scholar
  15. 15.
    Daly E, Gray A, Barlow D, McPherson K, Roche M, Vessey M. Measuring the impact of menopausal symptoms on quality of life. Br Med J 1993;307:836–40.CrossRefGoogle Scholar
  16. 16.
    Limouzin-Lamothe M, Mairon N, Joyce CR, LeGal M. Quality of life after the menopause: Influence of hormonal replacement therapy. Am J Obstet Gynecol 1994;170:618–24.PubMedGoogle Scholar
  17. 17.
    Sherwin BB. Menopause, early aging, and elderly women. In: Jensvold MF, Halbreich U, Hamilton JA, editors. Psychopharmacology and women: Sex, gender, and hormones. Washington, D.C.: American University Press, 1996:225–37.Google Scholar
  18. 18.
    Halbreich U, Lumley LA, Palter S, Manning C, et al. Possible acceleration of age effects on cognition following menopause. J Psychiatr Res 1995;29:153–63.PubMedCrossRefGoogle Scholar
  19. 19.
    Sherwin BB. Estrogen effects on cognition in menopausal women. Neurology 1997;48(Suppl.7):S17–20.Google Scholar
  20. 20.
    Halbreich U. Psychotropic effects of estrogen replacement therapy in menopause and Alzheimer’s disease. In: Brunello N, Langer SJ, Racagni G, editors. Mental disorders in the elderly: New therapeutic approaches. Int Acad Biomed Drug Res. Basel: Karger, 1998;13: 117–24.CrossRefGoogle Scholar
  21. 21.
    Sherwin BB. Cognitive assessment for postmenopausal women and general assessment of their mental health. Psychopharm Bull 1998; in press.Google Scholar
  22. 22.
    Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: A quantitative integration of the literature. Acta Psychiatr Scand 1987;76:465–79.PubMedGoogle Scholar
  23. 23.
    Herbert LE, Scherr PA, Beckett LA, Albert MS, et al. Age-specific incidence of Alzheimer’s disease in a community population. JAMA 1995;273:1354–59.CrossRefGoogle Scholar
  24. 24.
    Birge S. The role of estrogen in the treatment of Alzheimer’s disease. Neurology 1997;48(Suppl.7):S36–S41.PubMedGoogle Scholar
  25. 25.
    Birge SJ. The role of estrogen deficiency in the aging central nervous system. In: Lobo RA, editor. Treatment of the postmenopausal woman: Basic clinical aspects. New York: Raven Press, 1994:153–57.Google Scholar
  26. 26.
    Henderson VW, Paganini-Hill A, Emanuel CK, Dunn ME, et al. Estrogen replacement therapy in older women: Comparisons between Alzheimer’s disease cases and non-demented control subjects. Arch Neurol 1994;51:896–900.PubMedGoogle Scholar
  27. 27.
    Mortel KF, Meyer JS. Lack of postmenopausal estrogen replacement therapy and risk of dementia. J Neuropsychiatry Clin Neurosci 1995;334–37.Google Scholar
  28. 28.
    Paganini-Hill A, Henderson VW. Estrogen replacement therapy and risk of Alzheimer’s disease. Arch Intern Med 1996;156:2213–17.PubMedCrossRefGoogle Scholar
  29. 29.
    Singh M, Meyer EM, Simpkins JW. The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. Endocrinology 1995;136:2320–24.PubMedCrossRefGoogle Scholar
  30. 30.
    Simkins JW, Singh M, Bishop J. The potential role for estrogen replacement therapy in the treatment of the cognitive decline and neurodegeneration associated with Alzheimer’s disease. Neurobiology of Aging 1994;15(Suppl.2):S195–S197.CrossRefGoogle Scholar
  31. 31.
    Matsumoto A, Arai Y, Osanai M. Estrogen stimulates neuronal plasticity in the deafferented hypothalamic arcuate nucleus in aged female rats. Neuroscience Research 1985;2(5):412–18.PubMedCrossRefGoogle Scholar
  32. 32.
    Singh M, Meyer EM, Simpkins JW. Ovarian steroid deprivation results in a reversible learning impairmentand compromised cholinergic function in female Sprague-Dawley rats. Brain Res 1994;644:305–12.PubMedCrossRefGoogle Scholar
  33. 33.
    Ohkura T, Teshima Y, Isse K. Estrogen increases cerebral and cerebellar blood flow in postmenopausal women. Menopause 1994;2:13–18.Google Scholar
  34. 34.
    McEwen BS, Woolley CS. Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain. Exp Gerontol 1994;29:431–36.PubMedCrossRefGoogle Scholar
  35. 35.
    Halbreich U. Psychiatric disorders in women. In: Weiler M, van Kammen D, editors. Progress in clinical psychiatry. London: Saunders Company, 1997:96–115.Google Scholar

Copyright information

© Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 1999

Authors and Affiliations

  • Linda S. Kahn
  • Uriel Halbreich

There are no affiliations available

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