Recurrence of glomerulonephritis following renal transplantation

  • M. D. Denton
  • M. H. Sayegh
Part of the Developments in Nephrology book series (DINE, volume 40)


Glomerulonephritis is a major cause of end-stage renal disease (ESRD) and is the primary disease in over a third of patients undergoing renal transplantation. Recurrence of glomerulonephritis in the renal allograft represents a significant problem. Large data registries from the United States and Europe report a 4% to 7% incidence of graft loss secondary to recurrent glomerulo-nephritis in adults [1, 2]. Recurrence of glomerulonephritis imposes a greater impact on graft survival in paediatric transplant recipients [3]. Moreover, the relative impact of recurrent glomerulonephritis on allograft function and survival is predicted to increase as advances in transplant immunobiology and the development of specific immunosuppressive strategies reduce rejection-mediated graft loss. All forms of glomerulonephritis have been reported to recur histologically following renal transplantation, but the incidence and severity of clinical recurrence varies greatly according to the type of glomerular disease. This chapter attempts to clarify some of the salient clinical features of recurrent glomerulonephritis from a body of literature full of anecdotal reports and retrospective studies. Development of de-novo glomerulonephritis in the transplant will also be discussed. There are several excellent reviews on recurrent glomerulonephritis 4#x20138 and this chapter aims to complement these by focusing on more recent developments in the field.


Renal Transplantation Nephrotic Syndrome Graft Survival Plasma Exchange Hemolytic Uremic Syndrome 
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© Kluwer Academic Publishers 1999

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  • M. D. Denton
  • M. H. Sayegh

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