IgA nephropathy and Henoch-Schönlein purpura

  • J. Feehally
Part of the Developments in Nephrology book series (DINE, volume 40)


IgA nephropathy (IgAN) is a common pattern of glomerulonephritis defined by mesangial IgA deposition. It may occur at any age but most commonly presents in the second and third decades of life. Recurrent macroscopic haematuria is the most frequent clinical presentation but other patients present with microscopic haematuria, proteinuria or progressive renal failure. The apparent prevalence of the disease will increase if urine screening is widely used in any population in which renal biopsy is recommended for those with minor urine abnormalities. Hypertension is particularly common and usually predates renal impairment. Rapidly progressive renal failure is unusual; it may result from acute tubular necrosis as a consequence of macroscopic haematuria, or from superimposed crescentic nephritis. Recurrent IgA deposition after transplantation is common. IgA deposits are found in 50% of transplants, although structural glomerular injury is uncommon and the overall success of transplantation is not diminished.


Sodium Cromoglycate Minimal Change Nephrotic Syndrome Progressive Renal Failure Angiotensin Converting Enzyme Gene Chronic Glomerular Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1999

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  • J. Feehally

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