Immortalization of Hepatocytes through Targeted Deregulation of the Cell Cycle

  • G. S. Jennings
  • M. Strauss
Part of the Cell Engineering book series (CEEN, volume 1)


The generation of continuously proliferating hepatocytes expressing differentiated functions has been a goal long sought after by workers in the fields of liver toxicology and pathology, in recombinant protein technology and in gene therapy and medicine. The requirements of these disciplines will define the parameters for selecting an immortalization strategy and will ultimately pass judgement on the success of newly created cell lines.


Programme Cell Death Hepatocyte Growth Factor Primary Hepatocyte Retinoblastoma Protein Cell Cycle Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 1999

Authors and Affiliations

  1. 1.1HepaVec AGUSA
  2. 2.Department of Cell BiologyHumboldt University, Max-Delbrück-Center for Molecular MedicineBerlinGermany

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