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Stress, Depression, and The Role of Cytokines

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Cytokines, Stress, and Depression

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 461))

Abstract

The concept of an inter-relationship between the psychological state of a depressed patient and the immune status can be traced back to Galen who, in 200 AD, suggested that melancholic women are more susceptible to breast cancer than sanguine women (Leonard, 1987). Over the past 15 years it has become apparent that the central nervous system (CNS) and the immune system are intimately connected and that a functional bidirectional communication exists between these systems (Ballieux, 1992). Indeed, it may be possible to conceive of the nervous, endocrine, and immune systems as being part of a single integrated network rather than three separate systems. The study of the interactions between these systems has given rise to the new discipline of psychoimmunology, a term first coined by Ader, Feiten, and Cohen in 1987.

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References

  • Ader, R., Feiten, A., & Cohen, N. (1987). Brain, Behavior, Immunity. Brain, Behavior, and Immunity. 1987 (1) 1–6.

    Google Scholar 

  • Ader, R. & Cohen, N. (1991). Conditioning the immune system. Netherlands Journal of Medicine, 39, 263–276.

    CAS  PubMed  Google Scholar 

  • Almawi, W. Y., Beyhum, H. N., Rahme, A. A., & Rieder, M. J. (1996). Regulation of cytokine and cytokine receptor expression by glucocorticoids. Journal of Leucocyte Biology, 60, 5563–5572.

    Google Scholar 

  • Arber, N., Berliner, S., & Tamir, A. (1991). The state of leucocyte adhesiveness/aggregation in the peripheral blood: a new independent marker of stress. Stress Medicine, 7, 75–78.

    Article  Google Scholar 

  • Baldessarini, R. J. (1975). The basis for amine hypothesis in affective disorder: a critical evaluation. Archives of General Psychiatry, 32, 1087–1093.

    Article  CAS  PubMed  Google Scholar 

  • Ballieux, R. E. (1992). Bidirectional communication between the brain and the immune system. European Journal of Clinical Investigation, 22,1, 6–9.

    PubMed  Google Scholar 

  • Banks, W. A., Kastin, A. J., & Durham, D. A. (1989). Bidirectional transport of interleukin-1 alpha across the blood brain barrier. Brain Research Bulletin, 23, 77–84.

    Article  Google Scholar 

  • Bateman, A., Singh, A., Krai, T., & Solomon, S. (1989). The immune-hypothalamic-pituitary adrenal axis. Endocrine Reviews, 10, 92–112.

    Article  CAS  PubMed  Google Scholar 

  • Baumann, H. & Gauldie, J. (1994). The acute phase response. Immunology Today, 15, 74–80.

    Article  CAS  PubMed  Google Scholar 

  • Blotta, M. H. (1997). Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. Journal of Immunology, 158, 5589–5595.

    CAS  Google Scholar 

  • Borysenko, M. & Borysenko, J. (1982). Stress, behaviour and immunity: animal models and mediating mechanisms. General Hospital Psychiatry, 4, 59–67.

    Article  CAS  PubMed  Google Scholar 

  • Bost, K. L. (1988). Hormone and neuropeptide receptors on mononuclear leucocytes. Progress Allergy, 43, 68–83.

    CAS  Google Scholar 

  • Cohen, J. J. & Crnic, L. S. (1982). Glucocorticoids, stress, and the immune response. In D. R. Webb (Ed.). Immunopharmacology and the Regulation of Leucocyte Function. New York, Marcel Dekker, pp. 61–91.

    Google Scholar 

  • Connor, T. J. & Leonard, B. E. (1998). Depression, stress, and immunological activation: the role of cytokines in depressive disorders. Life Sciences, 62, 583–606.

    Article  CAS  PubMed  Google Scholar 

  • Cooper, C. L. (1984). The social-psychological pressors to cancer. Journal of Human Stress, 10, 4–11.

    Article  CAS  PubMed  Google Scholar 

  • Cox, T. M. & MacKay, C. (1982). Psychosocial factors and psychophysiological mechanism in the aetiology and development of cancers. Social Science and Medicine, 16, 381–396.

    Article  CAS  PubMed  Google Scholar 

  • Crestani, F., Seguy, F., & Dantzer, R. (1991). Behavioural effects of peripherally injected interleukin-1: role of prostaglandin. Brain Research, 542, 330–335.

    Article  CAS  PubMed  Google Scholar 

  • Croiset, G., Heijnen, C. J., Veldhuis, H. D., de Wied, D., & Ballieux, R. E. (1987). Modulation of the immune response by emotional stress. Life Sciences, 40, 775–782.

    Article  CAS  PubMed  Google Scholar 

  • Crook, T. H. & Miller, N. W. (1985). The challenge of Alzheimer’s disease. American Psychology, 40, 1245–1250.

    Article  CAS  Google Scholar 

  • Cunnick, J. E., Lysle, D. T, Aronfield, A., & Rabin, B. S. (1991). Stressor-induced changes in mitogenic activity are not associated with decreased IL-2 production or changes in lymphocyte subsets. Clinical Immunology and Immunopathology, 60, 419–429.

    Article  CAS  PubMed  Google Scholar 

  • Cunningham, E. T. & de Souza, E. B. (1996). Interleukin 1 receptors in the brain and endocrine tissue. Immunology Today, 14, 171–176.

    Google Scholar 

  • Dantzer, R. (1994). How do cytokines say hello to the brain? Neural versus humoral mediation. European Cytokine Network, 5, 271–273.

    CAS  PubMed  Google Scholar 

  • Dantzer, R., Bluthe, R. M., Aubert, A., Goodall, G., Bret-Dibat, J. L., Kent, S., Goujon, E., Laye, S., Parnet, P., & Kelley, K. W. (1996). Cytokine actions on behaviour. In Cytokines in the Nervous System. (Ed. Rothwell NJ), Chapman and Hall, London, 117–140.

    Chapter  Google Scholar 

  • Dark, K., Peeke, H. V. S., Ellman, G., & Salfi, M. (1987). Behaviourally conditioned histamine release. Annals of the New York Academy of Sciences, 496, 578–582.

    Article  CAS  PubMed  Google Scholar 

  • Davidson, L. M. & Baum, A. (1986). Chronic-stress and post traumatic stress disorder. Journal of Consultants in Clinical Psychology, 54, 303–308.

    Article  CAS  Google Scholar 

  • Daynes, R. A. & Araneo, B. A. (1989). Contrasting effects of glucocorticoids in the capacity of T cells to produce the growth factors interlukin 2 and interleukin 4. European Journal of Immunolgy. 19, 2319–2325.

    Article  CAS  Google Scholar 

  • Dinan, T. (1994). Glucocorticoids and the genesis of depressive illness—a psychobiological model. British Journal of Psychiatry, 164, 365–371.

    Article  CAS  Google Scholar 

  • Dohmus, J. E. & Metz, A. (1991). Stress mechanisms of immunosuppression. Veterinary Immunology and Immunopathology, 30, 89–109.

    Article  Google Scholar 

  • Farrar, W. L. (1988). Evidence for the common expression of neuroendocrine hormones and cytokines in the immune and central nervous system. Brain Behaviour and Immunity, 2, 322–327.

    Article  CAS  Google Scholar 

  • Fiore, J., Becker, J., & Cooppel, D. B. (1983). Social network interactions: a buffer or a stress? American Journal of Communications in Psychology, 11, 423–429.

    Article  CAS  Google Scholar 

  • Fleshner, M., Bellgrau, D., Watkins, L. R., Laudenslager, M. L., & Maier, S. F. (1995). Stress induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes. Journal of Neuroimmunology, 56, 45–52.

    Article  CAS  PubMed  Google Scholar 

  • Glaser, R., Kiecolt-Glaser, J. K., & Stout, J. C. (1985). Stress related impairments in cellular immunity. Psychiatric Research, 16, 233–239.

    Article  CAS  Google Scholar 

  • Glaser, R., Rice, T., & Speicher, C. E. (1986). Stress depresses interferon production by leucocytes concomitant with a decrease in natural killer cell activity. Behavioural Neuroscience, 100, 675–678.

    Article  CAS  Google Scholar 

  • Gottesfeld, A. & Liehr, J. G. (1987). Chronic exposure to random restraint stress retards the development of oestrogen-induced pituitary prolactinoma in rats. Neuroscience Letters, 80, 44–48.

    Article  CAS  PubMed  Google Scholar 

  • Gutierrez, E. G., Banks, W. A., & Kastin, A. J. (1993). Murine tumour necrosis factor alpha is transported from blood to brain in the mouse. Journal of Neuroimmunology, 47, 169–176.

    Article  CAS  PubMed  Google Scholar 

  • Hamblin, A. S. (1994). Cytokines. In Textbook of Immunopharmacology. 3rd Edition. M. M. Dale, M. M. J. C. Foreman, T. D. Fan (Eds.), Blackwell Scientific Publication, Oxford, pp. 179–192.

    Google Scholar 

  • Healy, D., Calvin, J., Whitehouse, A. M., White, W., Wilton-Cox, H., Theodorou, A. E., Lawrence, K. M., Hawton, R. W, & Paykel, E. S. (1991). Alpha-1-acid glycoprotein in major depressive and eating disorders. J. Affective Disorders (22), 13–20.

    Google Scholar 

  • Hellerstein, M. K., Meydani, S. N., Meydani, M., Wu, K., & Dinarello, C. A. (1989). Interleukin-1 induces anorexia in the rat. Journal of Clinical Investigations, 84, 28–235.

    Article  Google Scholar 

  • Hopkins, S. J. & Rothwell, N. J. (1995). Cytokines in the nervous system I: Expression and recognition. Trends in Neuroscience, 18, 83–88.

    Article  CAS  Google Scholar 

  • Irwin, M. (1995). Psychoneuroimmunology and depression In Psychopharmacology. The Fourth Generation of Progress. (Eds. Bloom, FE, Kupfer, DJ). Raven Press, New York, pp. 983–998.

    Google Scholar 

  • Irwin, M., Lacher, U. B., & Caldwell, C. (1992). Depression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects. Psychological Medicine, 22, 1045–1050.

    Article  CAS  PubMed  Google Scholar 

  • Katila, H., Rimon, R., Cantwell, K., Appelberg, B., & Nikkila, H. (1991). Interferon productions in acute psychiatric disorder. Psychiatric and Biological Factors, 16, 191–196.

    Article  Google Scholar 

  • Keller, S. E., Weiss, J. M., Schleifer, S. J., Miller, N. E., & Stein, M. (1981). Suppression of immunity by stress: effect of a gradient series of Stressors on lymphocyte stimulation in the rat. Science, 213, 1397–1400.

    Article  CAS  PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Garner, W., & Speicher, C. E. (1984). Psychosocial modifiers of immune competence in medical students. Psychosomatic Medicine, 46, 7–14.

    Article  CAS  PubMed  Google Scholar 

  • Kiecolt-Glaser, J. K., Fisher, L., & Ogrocki, P. (1987). Marital quality, marital disruption, and immune function. sychosomatic Medicine, 49, 13–34.

    Article  CAS  Google Scholar 

  • Kiecolt-Glaser, J. K. & Glaser, R. (1988). Methodological issue in behavioural immunology research in humans. Brain Behaviour and Immunity, 2, 67–78.

    Article  CAS  Google Scholar 

  • Kiecolt-Glaser, J. K., Dura, J. R., Speicher, C.E., Trask, O.J., & Glaser, R. (1991). Spousal caregivers of dementia victims: longitudinal changes in immunity and health. Psychosomatic Medicine, 53, 345–362.

    Article  CAS  PubMed  Google Scholar 

  • Komaki, G., Arimura, A., & Koves, K. (1991). Effect of intraveous injection of IL-IB on PGE2 levels in several brain areas as determined by microdialysis. Endocrinology and Metabolism, 143, 220–227.

    Google Scholar 

  • Kronfol, Z. & House, J. D. (1985). Depression, hypothalamic pituitary adrenal cortical activity and lymphocyte function. British Journal of Psychiatry, 148, 70–73.

    Article  Google Scholar 

  • Kronfol, Z. & House, J. D. (1989). Depression, HPA activity, and lymphocyte function. Act a Psychiatrica Scandinavica, 80, 142–147.

    Article  CAS  Google Scholar 

  • Lavicky, J. & Dunn, A. J. (1995). Endotoxin administration stimulates cerebral catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessed by microdialysis. Journal of Neuroscience Research, 40, 407–413.

    Article  CAS  PubMed  Google Scholar 

  • Leonard, B. E. (1987). Stress, the immune system and mental illness. Stress Medicine, 3, 257–258.

    Article  Google Scholar 

  • Leonard, B. E. (1990). Stress and the immune system: immunological aspects of depressive illness. International Reviews of Psychiatry, 2, 321–330.

    Article  Google Scholar 

  • Levy, S., Herberman, R., Lippman, M., & d’Angelo, T. (1987). Correlation of stress factors with sustained suppression of NKC activity and predicted prognosis in patients with breast cancer. Journal of Clinical Oncology, 5, 348–353.

    Article  CAS  PubMed  Google Scholar 

  • Linkowski, P., Mendlewicz, J., & Kerklofs, M. (1987). 24hr profiles of ACTH, cortisol, and growth hormone in major depressed illness: effect of AD treatment. Journal of Clinical Endocrinology and Metabolism, 65, 141–146.

    Article  CAS  PubMed  Google Scholar 

  • McAdams, C. & Leonard, B. E. (1993). Neutrophil and monocyte phagocytosis in depressed patients. Progress in Neuropsychopharmacology and Biological Psychiatry. 17, 971–984.

    Article  CAS  Google Scholar 

  • Maes, M., Smith, R., & Scharpe, S. (1995). The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinology, 20, 111–116.

    Article  CAS  PubMed  Google Scholar 

  • Maes, M., Planken, V. D., & Stevens, W. J. (1992). Leucocytosis, monocytosis, and neutrophilia: hallmarks of severe depression. Journal of Psychiatric Research, 261, 125–134.

    Article  Google Scholar 

  • Maes, M., Smith, R. S., Christophe, A., Cosyns, P., Desnyder, R., & Melzer, H. Y. (1996). Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4W6/C20:5W3 ratio in cholesteryl esters and phospholipids. Journal of Affective Disorders, 38, 35–46.

    Article  CAS  PubMed  Google Scholar 

  • Maes, M. & Smith, R. S. (1998). Fatty acids, cytokines, and major depression. Biological Psychiatry, 43, 313–314.

    Article  CAS  PubMed  Google Scholar 

  • Maier, S. F., Watkins, L. R., & Fleshner, M. (1994). Psychoneuroimmunology—the interface between behaviour, brain, and immunity. American Psychologist, 49, 1004–1017.

    Article  CAS  PubMed  Google Scholar 

  • Martin, R. C, Cloninger, R., Guze, S., & Clayton, P. (1985). Mortality in a follow-up to 500 psychiatric outpatients. I. Total mortality and II cause specific mortality. Archives of General Psychiatry, 47–54 and 58–66.

    Google Scholar 

  • Mason, J. W. (1971). A re-evaluation of the concept of “non-specificity” in stress theory. Journal of Psychiatric Research, 8, 123–140.

    Article  Google Scholar 

  • Mefford, I. N. & Heyes, M. P. (1990). Increased biogenic amine release in mouse hypothalamus following immunological challenge: antagonism by indomethacin. Journal of Neuroimmunology, 27, 55–62.

    Article  CAS  PubMed  Google Scholar 

  • Miller, A. H., Asmis, G. M., & Lackner, C. (1991). Depression, natural killer cell activity and cortisol secretion. Biological Psychiatry, 29, 878–886.

    Article  CAS  PubMed  Google Scholar 

  • Miller, A. H., Spencer, R. L., McEwen, B. S., & Stein, M. (1993). Depression, adrenal steroids, and the immune system. Annuals of Medicine, 25, 481–487.

    Article  CAS  Google Scholar 

  • Monjan, A. A. & Collector, M. I. (1977). Stress-induced modulation of immune response. Science, 196, 307–308.

    Article  CAS  PubMed  Google Scholar 

  • Mormede, P., Dantzer, R., Michaul, B., Kelly, K., & Le Maoal, M. (1988). Influence of Stressor predictability and behavioural control on lymphocyte reactivity, antibody response and neuroendocrine activation in rats. Physiology and Behaviour, 43, 577–583.

    Article  CAS  Google Scholar 

  • Munck, A. & Naray-Fejes-Toth, A. (1994). Glucocorticoids and stress: permissive and suppressive actions. Annals of the New York Academy of Sciences, 746, 115–130.

    Article  CAS  PubMed  Google Scholar 

  • Nathan, C. F. (1987). Secretory products of macrophages. Journal of Clinical Investigation, 79, 319–324.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nemeroff, C. B., Widlerlov, E., & Bissette, G. (1984). Elevated concentration of CSF-CRF-like immunoreactivity in depressed patients. Science, 226, 1342–1348.

    Article  CAS  PubMed  Google Scholar 

  • O’Neill, B. & Leonard, B. E. (1990). Abnormal zymosan-induced neutrophil chemiliuminescence as a marker of depression. Journal of Affective Disorders, 19, 265–272.

    Article  PubMed  Google Scholar 

  • Owens, M. J. & Nemeroff, C. B. (1991). Physiology and pharmacology of corticotropin releasing factor. Pharmacological Reviews, 43, 425–473.

    CAS  PubMed  Google Scholar 

  • Persky, V.W., Kempthone-Rawson, J., & Shekelle, R. B. (1991). Personality and risk of cancer: 20 year follow-up of the Western Electric Study. Psychosomatic Medicine, 49, 435–47.

    Article  Google Scholar 

  • Rabin, B. S., Cunnick, J. E., & Lysle, D. T. (1990). Stress induced alteration of immune function. Progress in Neuroendocrinology and Immunology, 3, 116–124.

    Google Scholar 

  • Ramamoorthy, S., Ramamoorthy, J. D., Pradad, P., Bhat, G. K., & Mahesh, V. B. (1995). Regulation of the human serotonin transporter by interleukin-1 beta. Biochemical Biophysics Research Communications, 216, 560–567.

    Article  CAS  Google Scholar 

  • Rasmussen, A. F. (1969). Emotions and immunity. Annals of the New York Academy of Sciences, 164, 458–462.

    Article  PubMed  Google Scholar 

  • Rivier, C. & Rivest, S. (1993). Mechanisms mediating the effects of cytokines on neuroendocrine functions in the rat. In Corticotrophin-releasing factor. W. W. Vale (Ed.), Ciba Foundation Symposium, 172, John Wiley & Sons, Chichester, UK, pp. 204–225.

    Google Scholar 

  • Schettini, G. (1990). Interleukin in the neuroendocrine system: from gene to function. Progress in Neuroendocrinimmunology, 3, 157–166.

    Google Scholar 

  • Schleifer, S. J., Keller, S. E., Siris, S. G., Davis, K. L., & Stein, M. (1985). Depression and Immunity: lymphocyte stimulation in ambulatory depressed patients. Archives of General Psychiatry, 42, 129–133.

    Article  CAS  PubMed  Google Scholar 

  • Schleifer, S. J., Keller, S. E., Bond, R. N., Cohen, J., & Stein, M. (1989). Major depressive disorder: role of age, sex, severity, and hospitalization. Archives of General Psychiatry, 46, 81–87.

    Article  CAS  PubMed  Google Scholar 

  • Shekelle, R. B., Raynor, W. J., & Ostfeld, A. M. (1981). Psychological depression and 17 years risk of death from cancer. Psychosomatic Medicine, 43, 117–125.

    Article  CAS  PubMed  Google Scholar 

  • Sklar, L. S. & Anisman, H. (1981). Stress and cancer. Psychological Bulletin, 89, 369–06.

    Article  CAS  PubMed  Google Scholar 

  • Smith, R. S. (1991). The macrophage theory of depression. Medical Hypothesis, 35, 298–306.

    Article  CAS  Google Scholar 

  • Solomon, G. F. (1969). Stress and antibody response in rats. International Archives of Allergy and Applied Immunology, 35, 97–104.

    Article  CAS  PubMed  Google Scholar 

  • Solvason, H. B., Ghanta, Y. K., & Hiramoto, R. N. (1988). Conditioned augmentation of Natural Killer Cell activity: independence from nociceptive effects and dependence on interferon beta. Journal of Immunology, 140, 661–665.

    CAS  Google Scholar 

  • Song, C, Dinan, T., & Leonard, B. E. (1994). Changes in immunoglobulin, complement and acute phase protein concentrations in depressed patients and normal controls. Journal of Affective Disorders, 30, 283–288.

    Article  CAS  PubMed  Google Scholar 

  • Tejwani, G. A., Gudehithlu, K. P., Hanissian, S. H., Gienapp, I. E., Whitacre, C. C, & Malarkey, W. B. (1991). Facilitation of dimethylbenaz (a) anthracine induced rat mammory tumorigenesis by restraint stress: role of beta endorphin, prolactin, and naltrexone. Carcinogenesis, 12, 637–641.

    Article  CAS  PubMed  Google Scholar 

  • Weisse, C. S. (1992). Depression and immunocompetence: a review of the literature. Psychological Bulletin, 7/7, 475–487.

    Article  Google Scholar 

  • Wiegers, G. J. & Reul, J. M. H. M. (1998). Induction of cytokines receptors by glucocorticoids: functional and pathological significance. Trends in Pharmacological Sciences, 19, 317–321.

    Article  CAS  PubMed  Google Scholar 

  • Wiegers, G. J., Labeur, M. S., Stec, I. E., Klinkert, W. E., Holsboer, F., & Reul, J. M. (1995). Glucocorticoids accelerate anti-T cell receptor induced T cell growth. Journal of Immunology, 155, 1893–1902.

    CAS  Google Scholar 

  • Wu, C. Y., Fargeas, G, Nakajima, T., & Delespesse, G. (1991). Glucocorticoids suppress the production of interleukin 4 by human lymphocytes. European Journal of Immunology, 10, 2645–2647.

    Article  Google Scholar 

  • Wu Sarfati, M., Heusser, C, Fourneir, S., Rubio-Trujillo, M., Peleman, R., & Delespesse, G. (1991). Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes. Journal of Clinical Investigations, 87, 870–877.

    Article  Google Scholar 

  • Xia, Z., De Piere, J. W, & Nassberger. L. (1996). TCA’s inhibit IL-6, IL-1 and TNF release in human blood monocytes and IL2 and interferon in T cells. Immunopharmacology, 34, 27–37.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, National University of Ireland, Galway, Ireland

    B. E. Leonard

  2. Life Sciences Research Institute, Carlton University, Ottawa, Ontario, Canada

    Cai Song

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  1. INRA-INSERM, Bordeaux, France

    Robert Dantzer

  2. CNRS, Paris, France

    Emmanuelle E. Wollman

  3. The Hebrew University of Jerusalem, Jerusalem, Israel

    Raz Yirmiya

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Leonard, B.E., Song, C. (1999). Stress, Depression, and The Role of Cytokines. In: Dantzer, R., Wollman, E.E., Yirmiya, R. (eds) Cytokines, Stress, and Depression. Advances in Experimental Medicine and Biology, vol 461. Springer, New York, NY. https://doi.org/10.1007/978-0-585-37970-8_14

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