Clinical antibiotic trials in coronary heart disease
As described in earlier chapters, mounting evidence suggests that Chlamydia pneumoniae may have a role in the development and/or progression of atherosclerosis and coronary heart disease (CHD). The data suggesting that C. pneumoniae are a potential causative agent in this setting far exceeds that for other proposed infectious agents, and is based on the findings of seroepidemiological studies, direct examination of atheromatous plaque specimens, in vitro experiments and animal models. A further important line of evidence has been the results of preliminary anti-chlamydial antibiotic intervention studies in CHD. This chapter focuses on the potential role of such antimicrobial therapy in the secondary prevention of CHD. The findings of preliminary pilot studies are reviewed, as are the aims and controversies surrounding subsequent large-scale, prospective intervention trials now in progress.
KeywordsMacrolide Antibiotic Epithelial Line Fluid Male Survivor Established Coronary Heart Disease Macrolide Therapy
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