Assessing the Progression of Renal Disease

  • Saulo Klahr


Chronic renal insufficiency, once established, tends to progress to end-stage renal failure. The underlying mechanisms have been difficult to elucidate, because the glomerulus and the interstitium have a rather limited repertoire of responses to injury, and the kidney, therefore, responds to a variety of insults in a monotonous fashion. Diverse pathogenetic mechanisms, i.e., vascular, metabolic, or immunologic disorders, may lead to sclerosis, a process in which diverse renal structures are replaced by collagen, fibroblasts and mesenchymal matrix, resulting in disruption of normal renal function (1).


Glomerular Filtration Rate Diabetic Nephropathy Chronic Renal Failure Chronic Renal Disease Glomerular Injury 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Saulo Klahr
    • 1
  1. 1.Department of MedicineThe Jewish Hospital of St. LouisSt. LouisUSA

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