Biocompatibility — Principles

  • Raymond M. Hakim
  • Jonathan Himmelfarb


The contact of blood with biomaterials used in hemodialysis, elicits an organized inflammatory response that involves the activation of the body’s defense against ‘nonself’. These reactions include not only the enzymatic cleavage of proteins, such as the complement, contact and coagulation pathways, but in addition, cellular events that are part of the inflammatory response. Activation of these cellular pathways can result indirectly from the products of activation of these protein pathways or from the direct interaction of these cells with foreign surfaces. In this chapter, several of these inflammatory responses which are relevant to the hemodialysis procedure will be outlined. The clinical relevance of these reactions are detailed elsewhere in this volume


Complement Activation Hemodialysis Membrane Hageman Factor Complement Effector Cytolytic Lymphocyte 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Raymond M. Hakim
    • 1
  • Jonathan Himmelfarb
    • 2
  1. 1.Renal DivisionS-3307 MCN, VUMCNashvilleUSA
  2. 2.Maine Nephrology Associates P.A.PortlandUSA

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