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Neurological Aspects of Dialysis Patients

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

This chapter is an update of the excellent one written by Jennekens and Jennekens-Schinkel in the previous edition of this textbook. Although there has been no breakthrough in the understanding of the neurological problems occurring in dialysis patients, the management of neurological patients has changed during the past few years, making it necessary to revise this chapter. Neurological complications in dialysis patients are common and diverse. Some relate to persistence of mild uraemia others complicate the dialysis procedure. A number of neurological disorders occur with relatively high frequency in patients requiring this form of therapy but do not relate to uraemia nor to the methods used for treatment

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References

  1. Raskin NH, Fishman RA: Neurological disorders in renal failure (first of two parts). N Engl J Med 294: 143, 1976

    Article  PubMed  CAS  Google Scholar 

  2. Leavitt S, Tyler HR: Studies in asterixis. Arch Neurol 10: 370, 1964

    Google Scholar 

  3. Shahani BT, Young RR: Asterixis — a disorder of the neural mechanisms underlying sustained muscle contraction. in The Motor System: Neurophysiology and Muscle Mechanisms, edited by Shahani M, Amsterdam, Elsevier Scientific Publishing Company, 1976, p 301

    Google Scholar 

  4. Young RR, Shahani BT: Unilateral asterixis produced by a discrete CNS lesion. Trans Am Neurol Assoc 101: 306, 1976

    PubMed  CAS  Google Scholar 

  5. Ericson G, Warren SE, Gribik M: Unilateral asterixis in a dialysis patient. JAMA 240: 671, 1978

    PubMed  CAS  Google Scholar 

  6. Degos JD, Verroust J, Bochareine A, Serdaru M, Barbizet J: Asterixis in focal brain lesions. Arch Neurol 36: 705, 1979

    PubMed  CAS  Google Scholar 

  7. Donat JR: Unilateral asterixis due to thalamic haemorrhage. Neurology 30: 83, 1980

    PubMed  CAS  Google Scholar 

  8. Kudo Y, Fukai M, Yamadori A: Asterixis due to pontine haemorrhage. J Neurol Neurosurg Psychiatry 48: 487, 1985

    PubMed  CAS  Google Scholar 

  9. Chadwick D, French AT: Uraemic myoclonus: an example of reticular reflex myoclonus. J Neurol Neurosurg Psychiatry 12: 52, 1979

    Google Scholar 

  10. Steinman TI, Yager HM: Catatonia in uremia. Ann Intern Med 89: 74, 1978

    PubMed  CAS  Google Scholar 

  11. Madonick MJ, Berke K, Schiffer I: Pleocytosis and meningeal signs in uremia: report on 62 cases. Arch Neurol Psychiat 64: 431, 1950

    CAS  PubMed  Google Scholar 

  12. Schreiner GE, Maher JF: Uremia. Biochemistry Pathogenesis and Treatment. Springfield IL, Charles C Thomas, 1961, p 256

    Google Scholar 

  13. Tyler HR: Neurologic disorders in renal failure. Am J Med 44: 734, 1968

    PubMed  CAS  Google Scholar 

  14. Jennekens FGI, Dorhout Mees EJ, Van der Most van Spijk D: Clinical aspects of uraemic polyneuropathy. Nephron 8: 414, 1971

    Google Scholar 

  15. Jacob JC, Gloor P, Elwan H: Electroencephalographic changes in chronic renal failure. Neurology 15: 419, 1965

    PubMed  CAS  Google Scholar 

  16. Luyten JAFM, Storm van Leeuwen W, Jennekens FGI: EEG in uraemic patients with neuropathy. Electroencephalogr Clin Neurophysiol 28: 423, 190

    Google Scholar 

  17. Cohen SN, Syndulko K, Rever B, Krant J, Coburn I, Tourtelotte WW: Visual evoked potentials and long latency event-related potentials in chronic renal failure. Neurology 33: 1219, 1983

    PubMed  CAS  Google Scholar 

  18. Komsuoglu SS, Mehta R, Jones LA, Harding GFA: Brainstem auditory evoked potentials in chronic renal failure and maintenance hemodialysis. Neurology 35: 419, 1985

    PubMed  CAS  Google Scholar 

  19. Brown JJ, Sufit RL, Sollinger HW: Visual evoked potential changes following renal transplantation. Electroencephalogr Clin Neurophysiol 66: 101, 1987

    PubMed  CAS  Google Scholar 

  20. Olsen S: The brain in uraemia. Acta Psychiatr Scand 36(Suppl 156): 1, 1961

    CAS  Google Scholar 

  21. Kiley J, Hines O: Electroencephalographic evaluation of uremia, wave frequency evaluation on 40 uremic patients. Arch Intern Med 116: 67, 1965

    PubMed  CAS  Google Scholar 

  22. Kiley JE, Woodruff MW, Pratt KL: Evaluation of encephalopathy by EEG frequcncy analysis in chronic dialysis patients. Clin Nephrol 5: 245, 1976

    PubMed  CAS  Google Scholar 

  23. Heyman A, Patterson JL Jr, Jones RW Jr: Cerebral circulation and metabolism in uremia. Circulation 3: 558, 1951

    PubMed  CAS  Google Scholar 

  24. Scheinberg P: Effects of uremia on cerebral blood flow and metabolism. Neurology 1: 101, 1954

    Google Scholar 

  25. Biasioli S, D’Andrea G, Feriani M, Chiarmante S, Fabris A, Ronco C, La Greca G: Uremic encephalopathy: an updating. Clin Nephrol 25: 57, 1986

    PubMed  CAS  Google Scholar 

  26. Minkoff L, Gaertner G, Darab M, Levin ML: Inhibition of brain sodium-potassium ATPase in uremic rats. J Lab Clin Med 80: 71, 1972

    PubMed  CAS  Google Scholar 

  27. Fraser CL, Sarnacki P, Arieff AI: Abnormal sodium transport in synaptosomes from brain of uremic rats. J Clin Invest 75: 2014, 1985

    PubMed  CAS  Google Scholar 

  28. Hicks AM, Young DS, Wootton IDP: The effects of uraemic blood constituents on certain cerebral enzymes. Clin Chim Acta 9: 228, 1964

    PubMed  CAS  Google Scholar 

  29. Bergström J: Uremia is an intoxication. Kidney Int 28(Suppl 17): S2, 1985

    Google Scholar 

  30. Massry SG: Neurotoxicity of parathyroid hormone in uremia. Kidney Int 28(Suppl 17): S5, 1985

    Google Scholar 

  31. Cooper JD, Lasarowitz VC, Arieff AI: Neurodiagnostic abnormalities in patients with acute renal failure. Evidence for neurotoxicity of parathyroid hormone. J Clin Invest 61: 1448, 1978

    PubMed  CAS  Google Scholar 

  32. Fraser CL, Sarnacki P, Arieff A: Calcium transport abnormalities in uremic rat brain synaptosomes. J Clin Invest 76: 1789, 1985

    PubMed  CAS  Google Scholar 

  33. Alfrey AC, Mishell JM, Burks J, Contiguglia SR, Rudolph H, Lewin E, Holmes JH: Syndrome of dyspraxia and multifocal seizures associated with chronic hemodialysis. Trans Am Soc Artif Intern Organs 18: 257, 1972

    PubMed  CAS  Google Scholar 

  34. Plum F, Posner JB: The Diagnosis of Stupor and Coma. Third edition, Philadelphia, FA Davis Co, 1980, p 250

    Google Scholar 

  35. Arieff AI, Llach F, Massry SG: Neurological manifestations and morbidity of hyponatremia: correlation with brain water and electrolytes. Medicine (Baltimore) 55: 121, 1976

    CAS  Google Scholar 

  36. Fishman RA: Neurological manifestations of hyponatremia. in Handbook of Clinical Nelarology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam. North Holland Publishing Company, 1976, p 495

    Google Scholar 

  37. Reynolds EH: Neurological aspects of potassium imbalance. in Handbook of Clinical Neurology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 463

    Google Scholar 

  38. Lockman L: Neurological aspects of acid-base metabolism. in Handbook of Clinical Neurology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 507

    Google Scholar 

  39. Tyler HR: Neurological disorders in renal failure. in Handbook of Clinical Neurology, Vol 27, edited by Vinken PI and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 391

    Google Scholar 

  40. Bradbury M: The Concept of a Blood Brain Barrier. New York, John Wiley and Sons, 1979

    Google Scholar 

  41. Davis FA, Schauf CL: Neurological manifestations of calcium imbalance. in Handbook of Clinical Neurology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 527

    Google Scholar 

  42. Frame B: Neuromuscular manifestations of parathyroid disease. in Handbook of Clinical Neurology, Vol 27, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Pubishing Company, 1976, p 283

    Google Scholar 

  43. Rivera-Vazques AB, Noriega-Sánchez A, Ramirez-Gonzalez R, Martinez-Maldonado M: Acute hypercalcemia in hemodialysis patients: distinction from ‘dialysis dementia’. Nephron 25: 243, 1980

    Google Scholar 

  44. Durlach J: Neuromuscular manifestations of magnesium imbalance. in Handbook of Clinical Neurology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 545

    Google Scholar 

  45. Kennedy AC, Linton AL, Luke RG, Renfrew S, Dinwoodi A: The pathogenesis and prevention of cerebral dysfunction during dialysis. Lancet 1:790, 1964

    PubMed  CAS  Google Scholar 

  46. Arieff AI, Massry SG, Barientos A, Kleeman CR: Brain water and electrolyte metabolism in uremia: effects of slow and rapid hemodialysis. Kidney Int 4:177, 1973

    PubMed  CAS  Google Scholar 

  47. Mann H, Stiller S: Elimination of sodium chloride as the cause of dialysis disequilibrium syndrome. (Abstract) Kidney Int 17: 401, 1980

    Google Scholar 

  48. Arieff AI, Guisado R, Massry SG, Lazarowitz VC: Central nervous system pH in uremia and the effect of hemodialysis. J Clin Invest 58: 306, 1976

    PubMed  CAS  Google Scholar 

  49. Arieff AI, Lazarowitz VC, Guisado R: Experimental dialysis disequilibrium syndrome: prevention with glycerol. Kidney Int 14:270, 1978

    PubMed  CAS  Google Scholar 

  50. La Greca G, Biasoli S, Chiaramonte S: Studies of brain density in hemodialysis and peritoneal dialysis. Nephron 21: 146, 1982

    Google Scholar 

  51. Bolton CF, Young GB: Neurological Complications of Renal Disease. Stoneham, MA, Butterworth-Heineman, 1990.

    Google Scholar 

  52. Hughes JR, Schreeder MT: EEG in dialysis encephalopathy. Neurology (NY) 30: 1148, 1980

    Google Scholar 

  53. Dunea G, Mahurkar SD, Mamdani B: Role of aluminum in dialysis dementia. Ann Intern Med 88: 502, 11978

    Google Scholar 

  54. Faris AA: Wernicke’s encephalopathy a compilation of chronic hemodialysis. Arch Neurol 18: 248, 1968

    Google Scholar 

  55. Victor M: The Wernicke Korsakoff syndrome. In Handbook of Clinical Neurology, Vol 28, edited by Vinken PJ and Bruyn GW, Amsterdam, North Holland Publishing Company, 1976, p 243

    Google Scholar 

  56. Dukes MNG: Meyler’s Side Effects of Drugs. Ninth edition, Anmterdam, Excerpla Medica. 1980, p 416

    Google Scholar 

  57. Schwankhaus JD, Massucci EF, Kurtzke JF: Cefazolininduced encephalopathy in a uremic patient. Ann Neurol 17: 211, 1985

    PubMed  CAS  Google Scholar 

  58. Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis and prolonged maintenance hemodialysis. N Engl J Med 290: 679, 1974

    Article  Google Scholar 

  59. Lazarus JM, Lowrie EG, Hampers CL, Merrill JP: Cardiovascular disease in uremic palients on hemodialysis. Kidney Int 7(Suppl 2): S167, 1975

    Google Scholar 

  60. Burke JF Jr, Francos GC, Moore LL, Cho SY. Lasker N: Accelerated atherosclerosis in chronic dialysis: another look. Nephron 21:181, 1978

    Article  PubMed  Google Scholar 

  61. Rostand SG, Greter JC, Kirk KA, Rutsky EA, Andreoli TE: Ischemic heart disease in patients with uremia undergoing maintenance hemodialysis. Kidney Int 16: 600, 1979

    PubMed  CAS  Google Scholar 

  62. Lundin AP, Friedman EA: Vascular consequences of maintenance hemodialysis. An unproven case, Nephron 21: 177, 1978

    PubMed  CAS  Google Scholar 

  63. Dinsdale HB: Hypertension and the central nervous system. in Current Neurology, edited by Tyler HR, Dawson DM, Boston, Houghton Mifflin Publ, 1978, p 196

    Google Scholar 

  64. Dinsdale HB: Hypertensive encephalopathy. in Stroke, Pathophysiology, Diagnosis and Management, edited by Barnett HJM, Stein BM, Mohr JP, Yatsu FM, New York, Churchill Livingstone, 1986, p 896

    Google Scholar 

  65. Chester EM, Agamanolis DP, Banker BQ, Victor M: Hypertensive encephalopathy: a clinicopathologic study of 20 cases. Neurology 28: 928, 1978

    PubMed  CAS  Google Scholar 

  66. Nag S, Robertson DM, Dinsdale HB: Cerebral cortical changes in acute experimental hypertension. An ultrastructural study. Lab Invest 36: 150. 1977

    PubMed  CAS  Google Scholar 

  67. Rosenberg G, Kornfeld M, Stovring J, Bicknell JM: Subcortical arteriosclerotic encephalopathy (Bingswanger): computerized tomography. Neurology 29: 1102, 1979

    PubMed  CAS  Google Scholar 

  68. Junck L, Herrick MK, Langston JW: CT-scan in subcortical arteriosclerotic encephalopathy. Neurology 30: 791. 1980

    Google Scholar 

  69. Olzewski J: Subcortical arteriosclerotic encephalopathy. World Neurology 3: 359, 1962

    Google Scholar 

  70. Biemond A: On Binswanger’s subcortical arteriosclerotie encephalopathy and the possibility of its clinical recognition. Psychiatr Neurol Neurosurg 73: 413, 1970

    CAS  Google Scholar 

  71. Caplan LR, Schoene WC: Clinical features of subcortical arteriosclerotic encephalopathy. Neurology 28: 1206, 1978

    PubMed  CAS  Google Scholar 

  72. 72. Editorial (anonymous): Binswanger’s encephalopathy. Lancet 1:923, 1981

    Google Scholar 

  73. Nichols FT III, Mohr JP: Binswanger’s subacute arteriosclerolic encephalopathy. in Stroke, Pathophysiology, Diagnosis and Management, edited by Barnett HJM, Mohr JP, Stein BM, Yatsu FM, New York, Churchill Livingstone, 1986, p 875

    Google Scholar 

  74. De Reuck J, Crevits L, De Coster W, Sieben G, van der Eecken H: Pathogenesis of Binswanger chronic progressive subconical encephalopathy. Neurology 30: 920, 1980

    PubMed  Google Scholar 

  75. Reinmuth OM: Transient ischemic attacks. in Current Neurology, Vol 1, edited by Tyler HR, Dawson DM, Boston, Houghton Mifflin Publ, 1978, p 166

    Google Scholar 

  76. Mohr JP, Pessin MS: Extracranial carotid artery disease. in Stroke, Pathophysiology, Diagnosis and Management, edited by Barnett HJM, Mohr JP, Stein BM, Yatsu FM, New York, Churchill Livingstone, 1986, p 293

    Google Scholar 

  77. Toole JF, Yuson CP: Transient ischemic attacks with normal arteriograms. Serious or benign prognosis. Ann Neurol 1: 100, 1977

    PubMed  CAS  Google Scholar 

  78. Pessin MS, Duncan GW, Mohr JP, Poskanzer DC: Clinical and angiographic features of carotid transient ischemic attacks. N Engl J Med 296: 358, 1977

    Article  PubMed  CAS  Google Scholar 

  79. Russo LS: Carotid system transient ischemic attacles: clinical, racial and angiographic correlations. Stroke 12: 470, 1982

    Google Scholar 

  80. Barnett HJM: Antithrombotic therapy in cerebral vascular disease; antispasmodics and fibrinolysins. in Stroke, Pathohysiology, Diagnosis and Management, edited by Barnett HJM, Mohr JP, Stein BM, Yatsu FM, New York, Churchill Livingstone, 1986, p 989

    Google Scholar 

  81. Gates PC, Barnett HJM, Silver MD: Cardiogenic stroke. in Stroke, Pathophysiology, Diagnosis and Management, edited by Barnett HJM, Mohr JP, Stein BM, Yatsu FM, New York, Churchill Livingstone, 1986, p 1085

    Google Scholar 

  82. Caplan LR: Intracranial hemorrhage. in Current Neurology, edited by Tyler HR, Dawson DM, Boston, Houghton Mifflin Publ, 1979, p 85

    Google Scholar 

  83. Little JR, Tubman DE, Ethier R: Cerebellar hemorrhage in adults: diagnosis by computerized tomography. J Neurosurg 48: 575, 1978

    PubMed  CAS  Google Scholar 

  84. Crowell RM, Ojemann RG: Spontaneous brain hemorrhage, surgical considerations. in Stroke, Pathophysiology, Diagnosis and Management, edited by Barnett HJM, Mohr SP, Stein BM, Yatsu FM, New York, Churchill Livingstone, 1986, p 1191

    Google Scholar 

  85. Snyder M, Renaudin J: Intracranial hemorrhage associated with anticoagulation therapy. Surg Neurol 7: 31, 1977

    PubMed  CAS  Google Scholar 

  86. Bechar M, Lakke JPW, Van der Hem GK, Beks JWF, Penning L: Subdural hematoma during long term hemodialysis. Arch Neurol 26: 513, 1972

    PubMed  CAS  Google Scholar 

  87. Leonard A, Shapiro FL: Subdural hematoma in regularly hemodialyzed patients. Ann Intern Med 82: 650, 1975

    PubMed  CAS  Google Scholar 

  88. Keane WF, Shapiro FL, Ray L: Incidence and type of infections occurring in 445 hemodialysis patients. Trans Am Soc Artif Intern Organs 23: 41, 1977

    PubMed  CAS  Google Scholar 

  89. Nsouli KA, Lazarus JM, Schoenbaum SC, Gottlieb MN, Lowrie EG, Shocair M: Bacteremic infection in hemodialysis. Arch Intern Med 139: 1255, 1979

    PubMed  CAS  Google Scholar 

  90. Reidenberg MM: The binding of drugs to plasma proteins and the interpretation of measurements of plasma concentration of drugs in patients with poor renal function. Am J Med 62: 466, 1977

    PubMed  CAS  Google Scholar 

  91. Depner T, Gulyassy PF, Stanfel DA, Jarrard EA: Plasma protein binding in uremia: extraction and characterization of an inhibitor. Kidney Int 18: 86, 1980

    PubMed  CAS  Google Scholar 

  92. Reynolds F, Jones NF, Zikoyanis PN, Smith SE: Salivary phenytoin concentrations in epilepsy and in chronic renal failure. Lancet 2: 384, 1976

    PubMed  CAS  Google Scholar 

  93. Bruni J, Wang LH, Marbury TC, Lee CS, Wilder BJ: Protein binding of valproic acid in uremic patients. Neurology 30: 557, 1980

    PubMed  CAS  Google Scholar 

  94. McGonigle RJS, Bewick M, Weston MJ, Parsons V: Progressive predominantly motor uraemic neuropathy. Acta Neurol Scand 71: 379, 1985

    Article  PubMed  CAS  Google Scholar 

  95. Bolton CF, Gilbert JJ, Hahn AF, Sibbald WJ: Polyneuropathy in critically ill patients. J Neurol Neurosur Psychiatry 47: 1223, 1984

    CAS  Google Scholar 

  96. Asbury AK: Neuropathies with renal failure, hepatic disorders, chronic respiratory insufficiency and critical illness. in Peripheral Neuropathy, edited by Dyck PJ, Thomas PK et al., Philadelphia, WB Saunders, 1993, p 1251

    Google Scholar 

  97. Said G, Boudier L, Selva J, Zingraff J, Drüecke T: Different patterns of uremic polyneuropathy: clinicopathologic study. Neurology 33: 567, 1983

    PubMed  CAS  Google Scholar 

  98. Mulder DW: Motor neuron disease. in Peripheral Neuropathy, edited by Dyck PJ, Thomas PK, Lambert EH, Philadelphia, WB Saunders Co, 1975, p 759

    Google Scholar 

  99. Callaghan N: Restless legs syndrome in uremic neuropathy. Neurology 17: 359, 1966

    Google Scholar 

  100. Boghen D: Successful treatment of restless legs with clonazepatn. Ann Neurol 6: 341, 1979

    Google Scholar 

  101. Jennekens FGI, Dorhout Mees EJ, Van der Most van Spijk D: Uraemic polyneuropathy. Nephron 8: 414, 1971

    Google Scholar 

  102. Nielsen VK: The peripheral nerve function in chronic renal failure. I Clinical symptoms and signs. Acta Med Scand 190: 105, 1971

    Article  PubMed  CAS  Google Scholar 

  103. Nielsen VK: The peripheral nerve function in chronic renal failure. VII Longitudinal course during terminal renal failure and regular dialysis. Acta Med Scand 195: 155, 1974

    Article  PubMed  CAS  Google Scholar 

  104. Nielsen VK: The peripheral nerve function in chronic renal failure. An analysis of the vibratory perception threshold. Acta Med Scand 191: 287, 1972

    PubMed  CAS  Google Scholar 

  105. Hennessy WJ, Siemsen AW: Autonomic neuropathy in chronic renal failure. Clin Res 16: 385, 1968

    Google Scholar 

  106. Kersch ES, Krohnfield SJ, Unger A, Popper RW, Cantor S, Conn K: Autonomic insufficiency in uremia as a cause of hemodialysis-induced hypotension. N Engl J Med 290: 650, 1974

    Article  Google Scholar 

  107. Röckel A, Henneman H, Sternagel-Haase A, Heidhand A: Uraemic sympathetic neuropathy after haemodialysis and transplantation. Eur J Clin Invest 9: 23, 1979

    PubMed  Google Scholar 

  108. Zuchelli P, Sturani A, Zuccala A, Santoro A, Degli Esposti E, Chiarini C: Dysfunction of the autonomic nervous system in patients with end-stage renal failure. Contr Nephrol 45: 69, 1985

    Google Scholar 

  109. Solders G, Persson A, Gutierrez A: Autonomic dysfunction in non-diabetic terminal uraemia. Acta Neurol Scand 71: 321, 1985

    PubMed  CAS  Google Scholar 

  110. Mallamaci F, Zoccali C, Cicareili M, Briggs JD: Autonomic function in uremic patients treated by hemodialysis or CAPD and in transplant patients. Clin Nephrol 25: 175, 1986

    PubMed  CAS  Google Scholar 

  111. Solders G: Autonomic function tests in healthy controls and in terminal uraemia. Acta Neurol Scandli: 638, 1986

    Google Scholar 

  112. Mentser MI, Clay S, Malekzadeh MH, Pennisi AJ, Ettenger RB, Uittenbogaart CH, Finc RN: Peripheral motor nerve conduction velocities in children undergoing chronic hemodialysis. Nephron 22: 337, 1978

    PubMed  CAS  Google Scholar 

  113. Chan JC, Eng G: Long-term hemodialysis and nerve conduction in children. Pediat Res 13: 591, 1979

    PubMed  CAS  Google Scholar 

  114. Nielsen VK: The peripheral nerve function in chronic renal failure. V Sensory and motor conduction velocity. Acta Med Scand 194: 445, 1973

    Article  PubMed  CAS  Google Scholar 

  115. Van der Most van Spijk D, Hoogland RA, Dijkstra S: Conduction velocities compared and related to degrees of renal insufficiency. in New Developments in Electromyography and Clinical Neurophysiology, Vol 2, edited by Desmedt JE, Basel, Karger, 1973, p 381

    Google Scholar 

  116. Dinn JJ, Crane DL: Schwann cell dysfunction in uraemia. J Neurol Neurosurg Psychiatry 33: 605, 1970

    PubMed  CAS  Google Scholar 

  117. Bergström J, Lindblom U, Norée LO: Preservation of peripheral nerve function in severe uraemia during treatment with low protein, high calorie diet and surplus of essential amino-acids. Acta Med Scand 51: 99, 1975

    Google Scholar 

  118. Capelli P, Di Paolo B, Evangelista M, Di Marco T, Albertazzi A: Low protein diet supplemented with essential amino acids and keto analogues. Effects on uremic polyneuropathy and encephalopathy. Contr Nephrol 53: 58, 1986

    Google Scholar 

  119. Caccia MR, Mangili A, Mecca G, Ubiali E, Zanoni P: Effects of haemodialytic treatment on uremic polyneuropathy. J Neurol 217: 193, 1977

    Google Scholar 

  120. Cadilhac J, Mion C, Duday H, Dapres G, Georgesco M: Motor nerve conduction velocities as an index of the efficiency of maintenance dialysis in patients with end-stage renal failure. in Peripheral Neuropathies, edited by Canal N, Pozza G, Amsterdam, Elsevier, North Holland Biomedical Press, 1978, p 211

    Google Scholar 

  121. Kurts SB, Wong VH, Anderson CF, Vogel JP, McCarthy JT, Mitchell JC, Kumar R, Johnson WJ: Continuous ambulatory peritoneal dialysis. Three years’ experience at the Mayo Clinic. Mayo Clin Proc 58: 633, 1983

    Google Scholar 

  122. Tegnér R, Lindholm B: Uremic polyneuropathy: different effects of hemodialysis and continuous ambulatory peritoneal dialysis. Acta Med Scand 218: 409, 1985

    Article  PubMed  Google Scholar 

  123. Stanley E, Brown JC, Pryor JS: Altered peripheral nerve function resulting from haemodialysis. J Neurol Neurosurg Psychiatry 40: 39, 1977

    PubMed  CAS  Google Scholar 

  124. Edwards AE, Kopple JD, Kornfeld CM: Vibrotactile threshold in patients undergoing maintenance dialysis. Arch Intern Med 132: 706, 1973

    PubMed  CAS  Google Scholar 

  125. Castaigne P, Cathala HP, Beaussart-Boulengé L, Petrover M: Effect of ischaemia on peripheral nerve function in patients with chronic renal failure undergoing dialysis treatment. J Neurol Neurosurg Psychiatry 35: 631, 1972

    PubMed  CAS  Google Scholar 

  126. Lowitzsch K, Göhring U, Hecking E, Köhler H: Refractory period, sensory conduction velocity and visual evoked potentials before and after haemodialysis. J Neurol Neurosurg Psychiatry 44: 121, 1981

    PubMed  CAS  Google Scholar 

  127. Dyck PJ, Johnson WJ, Lambert EH, O’Brien PC, Daube JR, Ovratt KF: Comparison of symptoms, chemistry and nerve function to assess adequacy of hemodialysis. Neurology 9: 1361, 1979

    Google Scholar 

  128. Nielsen VK: The peripheral nerve function in chronic renal failure, A survey. Acta Med Scand 573Suppl) 8 1975

    Google Scholar 

  129. Ibraham MM, Crosland JM, Honigsberger L, Bmes AD, Dawson-Edwards P, Newman CE, Robinson BHB: Effect of renal transplantation on uraemic neuropathy. Lancet 2: 739, 1974

    Google Scholar 

  130. Nielsen VK: The peripheral nerve function in chronic renal failure. IX Recovery after transplantation. Electrophysiological aspects (sensory and motor nerve conduction). Acta Med Scand 195: 171, 1974

    Article  PubMed  CAS  Google Scholar 

  131. Oh SJ, Clements RS, Lee YW, Diethelm AG: Rapid improvement in nerve conduction velocity following renal transplantation. Ann Neurol 4: 369, 1978

    PubMed  CAS  Google Scholar 

  132. Nielsen VK: The peripheral nerve function in chronic renal failure. VII Recovery after renal transplantation. Clinical aspects. Acta Med Scand 195: 163, 1974

    Article  PubMed  CAS  Google Scholar 

  133. Bolton CF: Electrophysiologic changes in uremic neuropathy after successful renal transplantation. Neurology 26: 152, 1976

    PubMed  CAS  Google Scholar 

  134. Asbury AK, Victor M, Adams RD: Uremic polyneuropathy. Arch Neurol 8: 413, 1963

    PubMed  CAS  Google Scholar 

  135. Forno L, Alston W: Uremic polyneuropathy. Acta Neurol Scand 43:640, 1967

    PubMed  CAS  Google Scholar 

  136. Jennekens FGI, Dorhout Mees EJ, van der Most van Spijk D: Nerve fibre degeneration in uraemic polyneuropathy. Proc Eur Dial Transplant Assoc 6: 191, 1969

    Google Scholar 

  137. Thomas PK, Hollinrake K, Lascelles RG, O’Sullivan DJ, Baillod RA, Moorhead JF, Mackenzie JC: The polyneuropathy of chronic renal failure. Brain 94: 761, 1971

    PubMed  CAS  Google Scholar 

  138. Dayan AD, Gardner-Thorpe C, Down PF, Gleadle RI: Peripheral neuropathy in uremia. Neurology 20: 649, 1970

    PubMed  CAS  Google Scholar 

  139. Dyck PJ, Johnson WJ, Lambert EH, O’Brien PC: Segmental demyelination secondary to axonal degeneration in uremic neuropathy. Mayo Clin Proc 46: 400, 1971

    PubMed  CAS  Google Scholar 

  140. Hansen S, Ballantyne JP: A quantitative electrophysiological study of uraemic neuropathy. J Neurol Neurosurg Psychiatry 41: 128, 1978

    PubMed  CAS  Google Scholar 

  141. Said G, Goulon-Goeau C, Slama G, Tchobroutsky G: Severe early-onset polyneuropathy in insulin-dependent diabetes mellitus. N Engl J Med 326: 1257, 1992

    Article  PubMed  CAS  Google Scholar 

  142. Pekelharing CA, Winkler C: Mitteilung über die Beriberi (Communication on beriberi). Dtsch Med Wochenschr 13: 845, 1887 (in German)

    Article  Google Scholar 

  143. Babb AL, Popovich RP, Christopher TG, Scribner BH: The genesis of the square meter-hour hypothesis. Trans Am Soc Artif Intern Organs 17: 81, 1971

    PubMed  CAS  Google Scholar 

  144. Tenckhoff H, Shilipetar G, Boen ST: One year’s experience with home peritoneal dialysis. Trans Am Soc Artif Intern Organs 11: 11, 1968

    Google Scholar 

  145. Raskin NH, Fishman RA: Neurological disorders in renal failure (Second of two parts). N Engl J Med 294: 204, 1976

    Article  PubMed  CAS  Google Scholar 

  146. Merrill JP: The search for ‘factor X’. Clin Nephrol 11: 56, 1979

    PubMed  CAS  Google Scholar 

  147. Baker LRI, Marshall RD: A reinvestigation of methylguanidine concentration in sera from normal and uraemic subjects. Clin Sci 41: 563, 1971

    PubMed  CAS  Google Scholar 

  148. Blumberg A, Esslen E, Bürgi W: Myoinositol — a uremic neurotoxin. Nephron 21: 186, 1971

    Google Scholar 

  149. Sterzel RB, Semar M, Lonergan ET, Treser G, Lange K: Relationship of nervous tissue transketolase to the neuropathy in chronic uremia. J Clin Invest 50: 2295, 1971

    PubMed  CAS  Google Scholar 

  150. Kopple JD, Dirige OV, Jacob M, Wang M, Swenseid ME: Transketolase activity in red blood cells in chronic uremia. Trans Am Soc Artif Intern Organs 18: 250, 1972

    PubMed  CAS  Google Scholar 

  151. Dobbelstein H, Körner WF, Mempel W, Grosse-Wilde H, Edel HH: Vitamin B6 deficiency in uremia and its implication for the depression of immune responses. Kidney Int 5: 233, 1974

    PubMed  CAS  Google Scholar 

  152. Nielsen VK: Pathophysiological aspects of uraemic neuropathy. in Peripheral Neuropathies, edited by Canal N, Pozza G, Amsterdam, Elsevier/North Holland Biomedical Press, 1978, p 197

    Google Scholar 

  153. Brismar T, Tegnér R: Experimental uremic neuropathy. Part 2 (Sodium permeability decrease and inactivation in potential clamped nerve fibres). J Neurol Sci 65: 37, 1984

    PubMed  CAS  Google Scholar 

  154. Goldstein DA, Chui LA, Massry SG: Effects of parathyroid hormone and uremia on peripheral nerve calcium and motor nerve conduction velocity. J Clin Invest 62: 88, 1978

    Article  PubMed  CAS  Google Scholar 

  155. Avram MM, Iancu M, Morrow P, Feinfeld D, Huatuco A: Uremic syndrome in man: new evidence for parathormone as a multisystem neurotoxin. Clin Nephrol 11: 59, 1979

    PubMed  CAS  Google Scholar 

  156. Schaefer K, Offerman G, Von Herrath D, Schröter R, Stolzer R, Arntz HR: Failure to show a correlation between serum parathyroid hormone, nerve conduction velocity and serum lipids in hemodialysis patients. Clin Nephrol 14: 81, 1980

    PubMed  CAS  Google Scholar 

  157. Driieke T, Chkoff N, DiGiulo S, Zingraff J, Delons S, Man NK, Jungers P, Crosnier J: Absence of increased motor nerve conduction velocity after parathyroidectomy in dialysis patients. (Abstract) Kidney Int 15: 449, 1979

    Google Scholar 

  158. Layzer RB: Neuromuscular Manifestations of Systemic Disease, Philadelphia, FA Davis Co, 1985, p 112

    Google Scholar 

  159. Pagani, C, Zoerle, C, Guaita MC, Bazzi C, Sovgato G, Torgi G: Carpal tunnel syndrome in long-term dialyzed patients. Contr Nephrol 45: 72, 1985

    Google Scholar 

  160. Warren DJ, Otieno LS: Carpal tunnel syndrome in patients on intermittent haemodialysis. Postgrad Med J 51: 450, 1975

    Article  PubMed  CAS  Google Scholar 

  161. Bosanac PR, Bilder B, Grunberg RW, Banach SF, Kintzel JE, Stephens HW: Post-permanent access neuropathy. Trans Am Soc Artif Intern Organs 23: 162, 1977

    PubMed  CAS  Google Scholar 

  162. Harding AE, LeFanu J: Carpal tunnel syndrome related to antebrachial Cimino-Brescia fistula. J Neurol Neurosurg Psychiatry 40: 511, 1977

    Article  PubMed  CAS  Google Scholar 

  163. Walts AE, Goodman MD, Matoru PA: Amyloid carpal tunnel syndrome and chronic hemodialysis. Am J Nephrol 5: 225, 1985

    Article  PubMed  CAS  Google Scholar 

  164. Chanard J, Lavaud S, Toupance O, Melin JP, Gillery P, Revillard JP: B2 microglobulin-associated amyloidosis in chronic haemodialysis patients. Lancet 1: 1212, 1986

    PubMed  CAS  Google Scholar 

  165. Ballardie FW, Kerr DNS, Tennent G, Pepys MB: Haemodialysis versus CAPD: equal predisposition to amyloidosis. Lancet 1: 795, 1986

    PubMed  CAS  Google Scholar 

  166. Hamilton DV, Evans DB, Henderson RG: Ulnar nerve lesion as complication of Cimino-Brescia arteriovenous fistula. Lancet 2: 1137, 1980

    PubMed  CAS  Google Scholar 

  167. Ahmad R, Raichura N: Ulnar nerve lesion as complication of Cimino-Brescia arteriovenous fistula. Lancet 2: 1381, 1980

    PubMed  CAS  Google Scholar 

  168. Bailey RR, Lynn KL: Arteriovenous shunts and nerve damage. Lancet 1: 211, 1981

    Google Scholar 

  169. Bolton CF, Driedger AA, Lindsay RM: Ischaemic neuropathy in uraemic patients caused by bovine arteriovenous shunt. J Neurol Neurosurg Psychiatry 42: 810, 1979

    PubMed  CAS  Google Scholar 

  170. Ahonen RE: Light microscopic study of striated muscle in uremia. Acta Neuropathol (Berl) 49: 51, 1980

    CAS  Google Scholar 

  171. Kopple JD: Abnormal amino acid and protein metabolism in uremia. Kidney Int 14: 340, 1983

    Google Scholar 

  172. Alvestrand A, Fürst P, Bergström J: Intracellular amino acids in uremia. Kidney Int 24(Suppl 16): 9, 1983

    CAS  Google Scholar 

  173. Jennekens FGI: Disuse, cachexia and ageing. in Skeletal Muscle Pathology, edited by Mastaglia FL, Walton JN, Edinburgh, London, New York, Churchill-Livingstone, 1981, p 605

    Google Scholar 

  174. DelCanale S, Fiaccadori E, Ronda N, Söderlund K, Antonucci C, Guariglia A: Muscle energy metabolism in uremia. Metabolism 35: 981, 1986

    CAS  Google Scholar 

  175. Bethlem J: Myopathies, Second edition, Amsterdam, Elsevier North Holland, 1980, p 269

    Google Scholar 

  176. Böhmer T, Bergrem H, Eiklid K: Carnitine deficiency induced during intermittent haemodialysis for renal failure. Lancet 1: 126, 1978

    PubMed  Google Scholar 

  177. Mingardi G, Bizzi A, Cini M, Licini R, Mecca G, Garatini S: Carnitine balance in hemodialyzed patients. Clin Nephrol 13: 269, 1980

    PubMed  CAS  Google Scholar 

  178. Bizzi A, Cini M, Garattini S, Mingardi G, Licini R, Mecca G: L-carnitine addition to haemodialysis liquid prevents plasma carnitine deficiency during dialysis. Lancet 1: 882, 1979

    PubMed  CAS  Google Scholar 

  179. DiMauro S, Trevissan C, Hays A: Disorders of lipid metabolism in muscle. Muscle Nerve 3: 369, 1980

    CAS  Google Scholar 

  180. Lacour B, Chanard J, Haguet M, Basile D, Assan R, Di Giulio S, Ciancioni C, Lebkiri B, Drüeke T, Funck Brentano JL: Carnitine improves lipid abnormalities in haemodialysis patients. Lancet 2: 763, 1980

    PubMed  CAS  Google Scholar 

  181. Bazzato G, Coli U, Landini S, Mezzina C, Ciman M: Myasthenia-like syndrome after D,Lbut not L-carnitine. Lancet 1: 1209, 1981

    PubMed  CAS  Google Scholar 

  182. Clair F, Caillat S, Soufir JC, Lafforgue B, Drüeke T, Said G: Syndrome myasthénique induit par la D,L carnitine chez un hémodialysé chronique. Press Méd 13: 1154, 1984

    CAS  Google Scholar 

  183. West TPJ: A comparison of predialysis and postdialysis cognitive abilities. Dial Transplant 7: 809, 1978

    Google Scholar 

  184. Hagberg B: A prospective study of patients in chronic hemodialysis III. Predictive value of intelligence, cognitive deficit and ego defense structures in rehabilitation. J Psychosom Res 18: 151, 1974

    PubMed  CAS  Google Scholar 

  185. Teschan PE, Ginn HE, Bourne JR, Ward JW: Neurobehavioral probes for adequacy of dialysis. Trans Am Soc Artif Intern Organs 23: 556, 1977

    PubMed  CAS  Google Scholar 

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C. Jacobs C. M. Kjellstrand K. M. Koch J. F. Winchester

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Said, G. (1996). Neurological Aspects of Dialysis Patients. In: Jacobs, C., Kjellstrand, C.M., Koch, K.M., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-36947-1_52

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