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Organ and Metabolic Complications — Abnormal Endocrine Function in Chronic Renal Failure

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Replacement of Renal Function by Dialysis

Abstract

Endocrine function is often abnormal in patients with chronic renal failure (CRF); these disturbances, though not life-threatening, diminish the quality of life and make interpretation of endocrine function tests difficult. The pathogenesis of these derangements are multi-factorial and complex in nature and can be classified as follows:

  • - Hormonal deficiency due to the absence of functioning renal mass — erythropoietin, 1,25 vitamin D3, renin and osteogenic or bone morphogenic protein, a bone growth promoting factor (1)

  • - Hormonal deficiency due to uremia — Testosterone

  • - Hormonal excess due to increased production — Parathyroid hormone (PTH), prolactin and growth hormone (GH)

  • - Hormonal excess due to decreased degradation — GH, prolactin, insulin and glucagon

  • - Altered feedback regulation — gonadal dysfunction and excess GH and prolactin production

  • - Altered hormone metabolism — impaired conversion of thyroxine to triiodothyronine

  • - Altered end organ responsiveness — insulin and PTH resistance

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Authors and Affiliations

  1. Department of Internal Medicine W336-16, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52246, USA

    Victoria S. Lim M.D. & Michael J. Flanigan M.D.

Authors
  1. Victoria S. Lim M.D.
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  2. Michael J. Flanigan M.D.
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Editor information

C. Jacobs C. M. Kjellstrand K. M. Koch J. F. Winchester

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© 1996 Kluwer Academic Publishers

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Lim, V.S., Flanigan, M.J. (1996). Organ and Metabolic Complications — Abnormal Endocrine Function in Chronic Renal Failure. In: Jacobs, C., Kjellstrand, C.M., Koch, K.M., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-36947-1_51

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  • DOI: https://doi.org/10.1007/978-0-585-36947-1_51

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-3610-5

  • Online ISBN: 978-0-585-36947-1

  • eBook Packages: Springer Book Archive

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