Organ and Metabolic Complications — Abnormal Endocrine Function in Chronic Renal Failure

  • Victoria S. Lim
  • Michael J. Flanigan


Endocrine function is often abnormal in patients with chronic renal failure (CRF); these disturbances, though not life-threatening, diminish the quality of life and make interpretation of endocrine function tests difficult. The pathogenesis of these derangements are multi-factorial and complex in nature and can be classified as follows:
  • - Hormonal deficiency due to the absence of functioning renal mass — erythropoietin, 1,25 vitamin D3, renin and osteogenic or bone morphogenic protein, a bone growth promoting factor (1)

  • - Hormonal deficiency due to uremia — Testosterone

  • - Hormonal excess due to increased production — Parathyroid hormone (PTH), prolactin and growth hormone (GH)

  • - Hormonal excess due to decreased degradation — GH, prolactin, insulin and glucagon

  • - Altered feedback regulation — gonadal dysfunction and excess GH and prolactin production

  • - Altered hormone metabolism — impaired conversion of thyroxine to triiodothyronine

  • - Altered end organ responsiveness — insulin and PTH resistance


Growth Hormone Luteinizing Hormone Chronic Renal Failure Plasma Cortisol Level Chronic Renal Failure Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Victoria S. Lim
    • 1
  • Michael J. Flanigan
    • 1
  1. 1.Department of Internal Medicine W336-16University of Iowa Hospitals and ClinicsIowa CityUSA

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