Immunological and Chronic Inflammatory Abnormalities in End Stage Renal Disease

  • Béatrice Descamps-Latscha
  • Paul Jungers


In the late fifties, Dammin and coworkers (1) reported increased survival of skin homografts in patients with end stage renal disease (ESRD), suggesting for the first time that chronic uremia could be associated with a state of immune deficiency. The impaired immunity of ESRD patients has since been widely confirmed by numerous reports (reviewed in (2)) showing an enhanced susceptibility to certain infectious diseases, such as tuberculosis and listeriosis, an abnormally high incidence of tumors, anergy in cutaneous delayed-type hypersensitivity reactions and defective responses to vaccines against viral diseases such as influenza and hepatitis. A paradoxical observation is that maintenance dialysis does not improve but rather worsens this state of immune deficiency


Dialysis Patient Hemodialysis Patient Nephrol Dial Transplant Uremic Patient Uremic Toxin 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Béatrice Descamps-Latscha
    • 1
  • Paul Jungers
    • 2
  1. 1.INSERM U.25 GH Necker-Enfants MaladesParisFrance
  2. 2.Department of NephrologyGH Necker-Enfants MaladesParisFrance

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