Hematological Problems of Renal Failure

  • Joseph W. Eschbach


Renal failure, whether acute or chronic, adversely affects a number of hematological parameters. Red cell production and destruction, granulocyte and lymphocyte function, platelet function and coagulation are affected to various degrees. These changes result in anemia, and an increased susceptibility to infection and hemorrhage. This chapter will deal primarily with the pathogenesis of the anemia of chronic renal failure, erythropoietin (Epo) metabolism, the treatment of this anemia with recombinant human Epo (epoetin), and the benefits of this therapy. Infection, immunological dysfunction and bleeding disorders are reviewed in Chapters 7B, 8 and 9.


Chronic Renal Failure Dialysis Patient Serum Ferritin Hemodialysis Patient Recombinant Human Erythropoietin 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Joseph W. Eschbach
    • 1
  1. 1.Department of MedicineUniversity of WashingtonSeattleUSA

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