Skip to main content

Blood Pressure Control in Chronic Hemodialysis Patients

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

Cardiovascular complications are the leading cause of mortality and morbidity in the population of end-stage renal disease (ESRD) patients on renal replacement therapy (1). Hypertension, either as a primary cause, or consequence of renal failure, is a major risk factor contributing to the high cardiovascular morbidity and mortality in uremic patients and has been found in approximately 80% of patients developing ESRD (2, 3). The prevalence of hypertension in ESRD varies somewhat according to the different etiologies of renal failure. Patients with glomerulonephritis, diseases involving small vessels (vasculitis, scleroderma) or diabetic nephropathy have hypertension more often than those with tubulointerstitial disease (4). Once dialysis is begun, 5 to 50% remain hypertensive on the basis of casual blood pressure (BP) measurements (5). Continuous BP monitoring has shown that the proportion of ESRD patients with uncontrolled hypertension is much higher than that whose BP is adequately controlled (85 versus 15%) (6). Hypertension increases the severity and incidence of left ventricular hypertrophy (LVH) (7, 8) and atherosclerosis (9), implying that the treatment of hypertension and the maintenance of a normal BP are mandatory in ESRD patients

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Raine AEG, Margreiter R, Brunner FP, Ehrich JHH, Geerlings W, Landais P, Loirat C, Mallick NP, Seiwood NH, Tufveson G, Valderrabano F: Report on management of renal failure in Europe, XXII, 1991. Nephrol Dial Transplant 7(Suppl 2): 7, 1992

    PubMed  Google Scholar 

  2. Acosta JH: Hypertension in chronic renal disease. Kidney Int 22: 702, 1982

    Google Scholar 

  3. Paganini EP, Fouad FM, Tarazi RC: Systemic hypertension in chronic renal failure, in The Heart and Renal Disease, edited by O’Rourke RA, Brenner BM, Stein JH, New York, Churchill Livingstone, 1984, p 127

    Google Scholar 

  4. Blythe WB: Natural history of hypertension in renal parenchymal disease. Am J Kidney Dis 5: A50, 1985

    PubMed  CAS  Google Scholar 

  5. White RP, Rubin AL: Blood pressure control in chronic dialysis patients, in Replacement of Renal Function by Dialysis, edited by Drukker W, Parsons FM, Maher JF, Boston, Martinus Nijhoff Publishers, 1983, p 575

    Google Scholar 

  6. Cheigh JS, Milite C, Sullivan JF, Rubin AL, Stenzel KH: Hypertension is not adequately controlled in hemodialysis patients. Am J Kidney Dis 19: 453, 1992

    PubMed  CAS  Google Scholar 

  7. Parfrey PS, Harnett JD, Griffiths SM, Gault MH, Barre P: Congestive heart failure in dialysis patients. Arch Intern Med 148: 1519, 1988

    PubMed  CAS  Google Scholar 

  8. London GM, Fabiani F: Left ventricular dysfunction in end-stage renal disease: echocardiographic insights, in Cardiac Dysfunction in Chronic Uremia, edited by Parfrey PS, Harnett JD, Boston, Kluwer Academic Publishers, 1992, p 17

    Google Scholar 

  9. Vincenti F, Amend WJ, Abele J, Feduska NJ, Salvatierra O: The role of hypertension in hemodialysis-associated atherosclerosis. Am J Med 68: 363, 1980

    PubMed  CAS  Google Scholar 

  10. Nichols WW, O’Rourke MF: Pulsatile pressure/flow relations, in McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles, 3rd edition, London, Edward Arnold, 1990, p 125

    Google Scholar 

  11. Guyton AC: The body’s approach to arterial pressure regulation, in Circulatory Physiology III — Arterial Pressure and Hypertension, Philadelphia, WB Saunders Company, 1980, p 1

    Google Scholar 

  12. Gallagher DE, O’Rourke MF: What is the arterial pressure? in Arterial Vasodilation, Mechanisms and Therapy, edited by O’Rourke M, Safar M, Dzau V, London, Edward Arnold, 1993, p 134

    Google Scholar 

  13. Brod J, Bahlman J, Cachovan M, Pretschner P: Development of hypertension in renal disease. Clin Sci 64: 141, 1983

    PubMed  CAS  Google Scholar 

  14. Tarazi RC, Ibrahim MM, Bravo EL, Dustan HP: Hemodynamic characteristics of primary aldosteronism. N Engl J Med 289: 1330, 1973

    Article  PubMed  CAS  Google Scholar 

  15. Ulrych M, Frohlich EC, Dustan HP, Page IH: Immediate hemodynamic effects of beta-adrenergic blockade with propranolol in normotensive and hypertensive man. Circulation 37: 411, 1968

    PubMed  CAS  Google Scholar 

  16. Guyton AC, Hall JE, Jackson TE: The basic kidney-blood volume-pressure regulatory system: he pressure diuresis and natriuresis phenomena, in Circulatory Physiology III — Arterial Pressure and Hypertension, Philadelphia, WB Saunders Company, 1980, p 87

    Google Scholar 

  17. Mancia G, Mark AL: Arterial baroreflexes in humans, in Handbook of Physiology, Section 2: The Cardiovascular System — Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Geiger SR, Am Physiol Soc, Bethesda, 1983, p 755

    Google Scholar 

  18. Mark AL, Mancia G: Cardiopulmonary baroreflexes in humans, in Handbook of Physiology, Section 2: The Cardiovascular System — Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Geiger SR, Am Physiol Soc, Bethesda, 1983, p 795

    Google Scholar 

  19. Powis DA, Donald DE: Involvement of renal α-and β — adrenoreceptors in release of renin by carotid baroreflex. Am J Physiol 236: H580, 1979

    PubMed  CAS  Google Scholar 

  20. Epstein M, Pins DS, Sancho J, Haber E: Suppression of plasma renin and plasma aldosterone during water immersion in normal man. J Clin Endocrinol Metab 411: 618, 1975

    Google Scholar 

  21. London GM, Guerin AP, Bouthier JD, London AM, Safar ME: Cardiopulmonary blood volume and plasma renin activity in normal and hypertensive humans. Am J Physiol 249 (Heart Circ Physiol 18): H807, 1985

    PubMed  CAS  Google Scholar 

  22. Epstein M, Preston S, Weitzman RE: Isoosmotic central blood volume expansion suppresses plasma arginine vasopressin in normal man. J Clin Endocrinol Metab 52: 256, 1981

    PubMed  CAS  Google Scholar 

  23. Rodeheffer RJ, Tanaka I, Imada T, Hollister AS, Robertson D, Inagami T: Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. J Am Coll Cardiol 8: 18, 1986

    PubMed  CAS  Google Scholar 

  24. de Wardener HE, MacGregor GA, Clarkson EM, Alaghband-Zadeh J, Bitensky L, Chayen J: Effect of sodium intake on ability of human plasma to inhibit renal Na+-K+-adenosine triphosphatase in vitro. Lancet i: 411, 1981

    Google Scholar 

  25. Guyton AC, Norman RA, Cowley AW Jr, DeClue JW: The renal function curve and its significance in long-term arterial pressure regulation, in Circulatory Physiology III: Arterial Pressure and Hypertension, Philadelphia, WB Saunders Company, 1980, p 100

    Google Scholar 

  26. Tarazi RC, Conway J: The hemodynamics of hypertension, in Hypertension: Physiopathology and Triatment, 2nd ed., edited by Genest J, Kuchel O, Hamet P, Cantin M, New York, McGraw-Hill Inc., 1983, p 15

    Google Scholar 

  27. Safar ME, London GM, Simon ACh, Chau HP: Volume factors, total exchangeable sodium, and potassium in hypertensive disease, in Hypertension: Physiopathology and Treatment, 2nd ed., edited by Genest J, Kuchel O, Hamet P, Cantin M, New York, McGraw-Hill Inc., 1983, p 43

    Google Scholar 

  28. Guyton AC, Granger JH, Coleman TG: Autoregulation of the total systemic circulation and its relation to control of cardiac output and arterial pressure. Circ Res 28(Suppl I): 193, 1971

    Google Scholar 

  29. Coleman TG, Bower JD, Langford HG, Guyton AC: Regulation of arterial pressure in the anephric state. Circulation 42: 509, 1970

    PubMed  CAS  Google Scholar 

  30. Ferrario CM, Page IH: Current view concerning cardiac output in the genesis of experimental hypertension. Circ Res 43: 821, 1978

    PubMed  CAS  Google Scholar 

  31. Folkow B: Cardiovascular structural adaptation: its role in the initiation and maintenance of primary hypertension. The fourth Volhard lecture. Clin Sci Mol Med 55(Suppl): s3, 1978

    Google Scholar 

  32. Harper RN, Moore MA, Marr MC, Watts LE, Hutchings PM: Arteriolar rarefaction in the conjunction of human essential hypertensives. Microvasc Res 16: 369, 1978

    PubMed  CAS  Google Scholar 

  33. Aalkjaer C, Pedersen EB, Danielsen H, Fjeldborg O, Jespersen B, Kjaer T, Sorensen SS, Mulvany MJ: Morphological and functional characteristics of isolated resistance vessels in advanced uremia. Clin Sci 71: 657, 1986

    PubMed  CAS  Google Scholar 

  34. London GM, Safar ME, Simon AC, Alexandre JM, Levenson JA, Weiss YA: Total effective compliance, cardiac output and fluid volumes in essential hypertension. Circulation 57: 995, 1978

    PubMed  CAS  Google Scholar 

  35. Safar ME, London GM, Levenson JA, Simon AC, Chau NP: Rapid dextran infusion in essential hypertension. Hypertension 1: 615, 1979

    PubMed  CAS  Google Scholar 

  36. London GM, Levenson JA, London AM, Simon AC, Safar ME: Systemic compliance, renal hemodynamics, and sodium excretion in hypertension. Kidney Int 26: 342, 1984

    PubMed  CAS  Google Scholar 

  37. Kim KE, Onesti G, Schwartz AB, Chinitz JL, Swartz C: Hemodynamics of hypertension in chronic endstage renal disease. Circulation 46: 456, 1972

    PubMed  CAS  Google Scholar 

  38. Kim KE, Onesti G, Del Guercio ET, Greco J, Fernandes M, Eidelson B, Swartz C: Sequential hemodynamic changes in end-stage renal disease and the anephric state during volume expansion. Hypertension 2: 102, 1980

    PubMed  CAS  Google Scholar 

  39. Safar ME, London GM, Weiss YA, Milliez PL: Overhydration and renin in hypertensive patients with terminal renal failure: a hemodynamic study. Clin Nephrol 5: 183, 1975

    Google Scholar 

  40. Kooman JP, Wijnen JAG, Draaijer P, van Bortel LMAB, Gladziwa U, Peltenburg HG et al.: Compliance and reactivity of the peripheral venous system in chronic intermittent hemodialysis. Kidney Int 41: 104, 1992

    Google Scholar 

  41. Kim KE, Onesti GL, Swartz CD: Hemodynamics of hypertension in uremia. Kidney Int 8: S155, 1975

    CAS  Google Scholar 

  42. Weidmann P, Beretta-Piccoli C, Steffen F, Blumberg A, Reubi FC: Hypertension in terminal renal failure. Kidney Int 9: 294, 1976

    PubMed  CAS  Google Scholar 

  43. Schultze G, Piefre S, Molzahn M: Blood pressure in terminal renal failure. Fluid spaces and the renin angiotensin system. Nephron 25: 12, 1980

    Google Scholar 

  44. Davies DL, McElroy K, Atkinson AB, Brown JJ, Cumming AMM, Fraser R et al.: Relationship between exchangeable sodium and blood pressure in different forms of hypertension in man. Clin Sci Mol Med 57: 69S, 1979

    Google Scholar 

  45. Schalekamp MA, Beevers AG, Briggs JD, Brown JJ, Davies DL, Fraser R et al.: Hypertension in chronic renal failure. An abnormal relation between sodium and the renin-angiotensin system. Am J Med 55: 379, 1973

    PubMed  CAS  Google Scholar 

  46. Koomans HA, Geers AB, Boer P: A study on the distribution of body fluid after rapid saline expansion in normal subjects and in patients with renal insufficiency: preferential intravascular deposition in renal failure. Clin Sci 64: 153, 1983

    PubMed  CAS  Google Scholar 

  47. Lucas J. Floyer MA: Renal control of changes in the compliance of the interstitial space; factor in the aetiology of renoprival hypertension. Clin Sci 44: 397, 1973

    PubMed  CAS  Google Scholar 

  48. Koomans HA, Roos JC, Dorhout Mees EJ, Delawi IMK: Sodium balance in renal failure: a comparison of patients with normal subjects under extremes of sodium intake. Hypertension 7: 714, 1985

    PubMed  CAS  Google Scholar 

  49. Kornerup HJ: Hypertension in end-stage kidney disease. Acta Med Scand 200: 257, 1976

    Article  PubMed  CAS  Google Scholar 

  50. Onesti G, Kim KE, Greco JA, Del Guercio ET, Fernandes M, Swartz C: Blood pressure regulation in end-stage renal disease and anephric man. Circ Res 36&37(Suppl I): I145, 1975

    Google Scholar 

  51. Panza JA, Quyyumi AA, Brush JE, Epstein SE: Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 323: 22, 1990

    Article  PubMed  CAS  Google Scholar 

  52. Vallance P, Leone A, Calver A, Collier J, Moncada S: Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572, 1992

    PubMed  CAS  Google Scholar 

  53. Koyama H, Nishzawa Y, Morii H, Tabata T, Inoue T, Yamaji T: Plasma endothelin levels in patients with uremia. Lancet i: 99, 1989

    Google Scholar 

  54. Gonick HC, Kramer HJ, Paul W, Lu E: Circulating inhibitor of sodium-potassium activated adenosine triphosphatase after expansion of extracellular fluid volume in rats. Clin Sci Mol Med 53: 329, 1977

    PubMed  CAS  Google Scholar 

  55. Ludens JH, Clark MA, DuCharme DW, Harris DW, Lutzke BS, Mandel F et al.: Purification of an endogenous digitalis-like factor from human plasma for structural analysis. Hypertension 7: 923, 1991

    Google Scholar 

  56. de Wardener HE, MacGregor GA: Dahl’s hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: its possible role in essential hypertension. Kidney Int 18: 1, 1980

    PubMed  Google Scholar 

  57. Blaustein MP, Hamlyn JM: Sodium transport inhibition, cell calcium and hypertension. The natriuretic hormone/Na+-Ca++ exchange/Hypertension hypothesis. Am J Med 77: 45, 1984

    PubMed  CAS  Google Scholar 

  58. Graves SW, Brown B, Valdes R Jr: An endogenous digoxin-like substance in patients with renal impairment. Ann Intern Med 99: 604, 1983

    PubMed  CAS  Google Scholar 

  59. Cheng JT, Kahn T, Kaji DM: Mechanisms of alteration of sodium potassium pump of erythrocytes from patients with chronic renal failure. J Clin Invest 74: 1811, 1984

    PubMed  CAS  Google Scholar 

  60. Bisordi JE, Holt S: Digitalis-like immunoreactive substances and extracellular fluid volume status in chronic hemodialysis patients. Am J Kidney Dis 13: 396, 1989

    PubMed  CAS  Google Scholar 

  61. Boero R, Guarena C, Berto IM, Deabate MC, Rosati C, Quarello F, Piccoli G: Erythrocyte Na, K pump activity and arterial hypertension in uremic dialysed patients. Kidney Int 34: 691, 1988

    PubMed  CAS  Google Scholar 

  62. Izumo H, Izumo S, De Luise M, Flier JS: Erythrocyte Na K pump in uremia. Acute correction of a transport defect by hemodialysis. J Clin Invest 74: 581, 1984

    PubMed  CAS  Google Scholar 

  63. Thomas TH, Mansy H, Wilkinson R: Erythrocyte sodium and sodium flux in relation to hypertension in chronic renal failure. Nephrol Dial Transplant 4: 21, 1989

    PubMed  CAS  Google Scholar 

  64. Salvetti A, Bozzo MV, Graziola M, Abdel-Haq B: Acute hemodynamic effect of nifedipine in hypertension with chronic renal failure: the influence of volume status. J Cardiovasc Pharmacol 10(Suppl 10): 143, 1987

    Google Scholar 

  65. London GM, Marchais SJ, Guerin AP, Metivier F, Safar ME, Fabiani F et al.: Salt and water retention and calcium blockade in chronic uremia. Circulation 82: 105, 1990

    PubMed  CAS  Google Scholar 

  66. Raine AEG, Bedford L, Simpson AWM, Ashley CC, Brown R, Woodhead JS, Ledingham JGG: Hyperparathyroidism, platelet intracellular free calcium and hypertension in chronic renal failure. Kidney Int 43: 700, 1993

    PubMed  CAS  Google Scholar 

  67. Gafter U, Malachi T, Barak H, Djaldeti M, Levi J: Red blood cell calcium homeostasis in patients with endstage renal disease. J Lab Clin Med 114: 222, 1989

    PubMed  CAS  Google Scholar 

  68. Lindner A, Gagne E-R, Zingraff J, Jungers P, Dracke TB, Hannaert P, Garay R: A circulating inhibitor of the RBC membrane calcium pump in chronic renal failure. Kidney Int 42: 1328, 1992

    PubMed  CAS  Google Scholar 

  69. Guerin AP, London GM, Marchais SJ, Metivier F, Safar ME, Sassano P: Parathyroid hormone and cardiovascular effects of dihydropyridines in chronic renal failure. Am J Hypertens 3: 566, 1990

    PubMed  CAS  Google Scholar 

  70. DelGreco F, Davies WA, Simon NM, Huang C, Krumlovsky FA: Hypertension of chronic renal failure: role of sodium and renal pressor system. Kidney Int 7: S176, 1975

    Google Scholar 

  71. Bianchi G, Ponticemi C, Bardi V, Redae MB, Campolo L, De Ponti CZ et al.: Role of the kidney in salt-and water-dependent hypertension of end-stage renal disease. Clin Sci Mol Med 42:47, 1972

    CAS  Google Scholar 

  72. Weidmann P, Maxwell MH: The renin-angiotensin-aldosterone system in terminal renal failure. Kidney Int 8: S219, 1975

    Google Scholar 

  73. Fadem SZ, Lifschitz MD: Use of saralasin in end-stage renal disease. Kidney Int 15: S93, 1979

    Google Scholar 

  74. Henrich WL, Katz FH, Molinoff PB, Schrier RW: Competitive effects of hypokalemia and volume depletion on plasma renin activity, aldosterone and catecholamines. Kidney Int, 12: 279, 1977

    PubMed  CAS  Google Scholar 

  75. Wehle B, Asaba H, Castenfors J, Farst P, Gunnarsson B, Shaldon S et al.: Hemodynamic changes during sequential Ultrafiltration and dialysis. Kidney Int 15: 411, 1979

    PubMed  CAS  Google Scholar 

  76. Textor SC, Gavras H, Tifft CP, Bernard DB, Idelson B, Brunner HR: Norepinephrine and renin activity in chronic renal failure. Hypertension 3: 294, 1981

    PubMed  CAS  Google Scholar 

  77. Leenen FH, Galla SJ, Redmon DP, Vagnucci AH, McDonald RH, Shapiro AP: Relationship of the reninangiotensin-aldosterone system and sodium balance to blood pressure regulation in chronic renal failure of polycystic kidney disease. Metabolism 24: 589, 1975

    PubMed  CAS  Google Scholar 

  78. Brunner HR, Wauters JP, McKinstry D, Waeber B, Turini G, Gavras H: Inappropriate renin secretion masked by captopril in hypertension of chronic renal failure. Lancet 2: 704, 1978

    PubMed  CAS  Google Scholar 

  79. Guerin A, Resplandy G, Marchais S, Taillard F, London G: The effect of haemodialysis on the pharmacokinetics of perindoprilat after long-term perindopril. Eur J Clin Pharmacol 44: 183, 1993

    PubMed  CAS  Google Scholar 

  80. Dzau VJ: Tissue renin-angiotensin system in myocardial hypertrophy and failure. Arch Int Med 153: 937, 1993

    CAS  Google Scholar 

  81. McGrath BP, Ledingham JGG, Benedict CR: Catecholamines in peripheral venous plasma in patients on chronic hemodialysis. Clin Sci Mol Med 55: 89, 1975

    Google Scholar 

  82. Izzo JL Jr, Izzo MS, Stems RH, Freeman RB: Sympathetic nervous system hyperactivity in maintenance hemodialysis patients. Trans Am Soc Artif Intern Organs 28: 604, 1982

    PubMed  Google Scholar 

  83. Elias AN, Vaziri ND, Maksy M: Plasma norepinephrine, epinephrine and dopamine levels in end-stage renal disease. Arch Intern Med 145: 1013, 1985

    PubMed  CAS  Google Scholar 

  84. Cuche JL, Prinseau J, Selz F, Ruget G, Baglin A: Plasma free-, sulfo-and glucuro-conjugated catecholamines in uremic patients. Kidney Int 30: 566, 1986

    PubMed  CAS  Google Scholar 

  85. Campese V, Romoff MS, Levitan D, Lane K, Massry SG: Mechanisms of autonomic nervous system dysfunction in uremia. Kidney Int 20: 246, 1981

    PubMed  CAS  Google Scholar 

  86. Kettner A, Goldberg A, Hagberg J, Delmez J, Harter H: Cardiovascular and metabolic responses to submaximal exercise in hemodialysis patients. Kidney Int 26: 66, 1984

    PubMed  CAS  Google Scholar 

  87. Corder CN, Sharma J, McDonald RH Jr: Variable levels of plasma catecholamines and dopamine-beta-hydroxylase in hemodialysis patients. Nephron 23: 267, 1980

    Google Scholar 

  88. Corneille L, Lachance S, Demassieux S, Carrier S: Turnover of free and conjugated serum catecholamines during hemodialysis. Clin Invest Med 6: 12, 1983

    Google Scholar 

  89. Spohr U, Schneider HW, Streicher E, Schrack R, Ritz E: Hemofiltration and plasma dopamine-beta-hydroxylase activity. Nephron 25: 121, 1980

    PubMed  CAS  Google Scholar 

  90. Ratge D, Augustin R, Wisser H: Catecholamines, renin, aldosterone and arterial pressure in patients on chronic hemodialysis treatment. Int J Artif Organs 6: 255, 1983

    PubMed  CAS  Google Scholar 

  91. Baldamus CA, Ernst W. Frei U, Koch KM: Sympathetic and hemodynamic response to volume removal during different forms of renal replacement therapy. Nephron 31: 324, 1982

    PubMed  CAS  Google Scholar 

  92. Frewin DB, Bartholomeusz FDL, Cummings MF, Clarkson AR, Barry LA, Furber B et al.: Changes in plasma catecholamine levels during hemodialysis. Aust NZ J Med 14:31, 1974

    Google Scholar 

  93. Zucchelli P, Catizone L, Degli Esposti E, Fusaroli M, Ligabue A, Zuccala A: Influence of ultrafiltration on plasma renin activity and adrenergic system. Nephron 21: 31, 1978

    Google Scholar 

  94. Atuk NO, Bailey CJ, Turner S, Peach MJ, Westervelt FB: Red blood cell catechol-0-methyl transferase, plasma catecholamines and renin in renal failure. Trans Am Soc Artif Intern Organs 22: 195, 1976

    PubMed  CAS  Google Scholar 

  95. Ziegler MG, Kennedy B, Morrissey E, O’Connor DT: Norepinephrine clearance, chromogranin A and dopamine-13-hydroxylase in renal failure. Kidney Int 37: 1357, 1990

    PubMed  CAS  Google Scholar 

  96. Rascher W. Schömig A, Kreye VA, Ritz E: Diminished vascular response to noradrenaline in experimental chronic uremia. Kidney Int 21: 20, 1982

    PubMed  CAS  Google Scholar 

  97. Smogorzewski M, Campese VM, Massry SG: Abnormal norepinephrine uptake and release in brain synaptosomes in chronic renal failure. Kidney Int 36: 458, 1980

    Google Scholar 

  98. Converse RL Jr, Jacobsen TN, Toto RD, Jost CMT, Cosentino F, Fouad-Tarazi F et al.: Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327: 1912, 1992

    Article  PubMed  Google Scholar 

  99. Lazarus JM, Hampers HD, Lowrie EG, Merril JP: Baroreceptor activity in normotensive and hypertensive uraemic patients. Circulation 47: 1015, 1973

    PubMed  CAS  Google Scholar 

  100. Grassi G, Parati G, Pomidossi G, Giannattasio C, Casadei R, Bolla G; et al.: Effects of haemodialysis and kidney transplantation on carotid and cardiopulmonary baroreflexes in uraemic patients. J of Hypertension 5(Suppl 5): S367, 1987

    Google Scholar 

  101. DiBona GF: The function of the renal nerves. Rev Physiol Biochem Pharmacol 94: 76, 1982

    Google Scholar 

  102. Faber JE, Brody MJ: Afferent renal nerve-dependent hypertension following acute renal artery stenosis in the conscious rat. Circ Res 57: 676, 1985

    PubMed  CAS  Google Scholar 

  103. Zimlichman RR, Chaimovitz C, Chaichenco Y, Goligorsky M, Rapoport J, Kaplansky J: Vascular hypersensitivity to noradrenaline: a possible mechanism of hypertension in rats with chronic uremia. Clin Sci 67: 161, 1984

    PubMed  CAS  Google Scholar 

  104. Iseki K, Massry SG, Campese VM: Evidence for a role of PTH in the reduced pressor response to norepinephrine in chronic renal failure. Kidney Int 28: 12, 1983

    Google Scholar 

  105. Brodde O-E, Daul A: Alpha-and beta-adrenoreceptor changes in patients on maintenance hemodialysis. Contr Nephrol 41:99, 1984

    CAS  Google Scholar 

  106. Shohn D, Weidmann P, Jahn H, Beretta-Piccoli C: Norepinephrine-related mechanism in hypertension accompanying renal failure. Kidney Int 28: 814, 1985

    Google Scholar 

  107. Manning RD, Guyton AC, Coleman TG, McCaa RE: Hypertension in dogs during antidiuretic hormone and hypotonic saline infusion. Am J Physiol 236: H314, 1979

    PubMed  CAS  Google Scholar 

  108. Fasanella D’Amore T, Wauters JP, Waeber B, Nussberger J, Brunner HR: Response of plasma vasopressin to changes in extracellular volume and/or plasma osmolality in patients on maintenance hemodialysis. Clin Nephrol 23: 299, 1985

    PubMed  CAS  Google Scholar 

  109. Jawadi MH, Ho LS, Dipette D, Ross DL: Regulation of plasma arginine vasopressin in patients with chronic renal failure maintained on hemodialysis. Am J Nephrol 6: 175, 1986

    PubMed  CAS  Google Scholar 

  110. Zoccali C, Mallamaci F, Ciccarelli M, Parlongo S, Salnitro F, Curatola A: The reflex control of vasopressin in haemodialysis patients. Nephrol Dial Transplant 6: 631. 1991

    PubMed  CAS  Google Scholar 

  111. Gavras H, Ribeiro AB, Kohlmann O. Saragoca M, Mulinari RA, Ramos OZ et al.: Effects of a specific inhibitor of the vascular action of vasopressin in human. Hypertension 6(Suppl I): 1156, 1984

    Google Scholar 

  112. Furchgott RF, Zawadski JW: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373, 1980

    PubMed  CAS  Google Scholar 

  113. Griffith TM, Edwards DH, Davies RL, Harrion TJ, Evans RT: EDRF coordinates the behaviour of vascular resistance vessels. Nature 329: 442, 1987

    PubMed  CAS  Google Scholar 

  114. Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide accounts for the biological activity of endotheliumderived relaxing factor. Nature 327: 524, 1987

    PubMed  CAS  Google Scholar 

  115. Noris M, Benigni A, Boccardo P, Aiello S, Gaspari F, Todeschini M et al.: Enhanced nitric oxyde synthesis in uremia: implications for platelet dysfunction and dialysis hypotension. Kidney Int 44: 445, 1993

    PubMed  CAS  Google Scholar 

  116. Warrens AN, Cassidy MJD, Takahashi K, Ghatei MA, Bloom SR: Endothelin in renal failure. Nephrol Dial Transplant 5: 418, 1990

    PubMed  CAS  Google Scholar 

  117. Rascher W, Tulassy T, Lang RE: Atrial natriuretic peptide in plasma of volume-overloaded children with chronic renal failure. Lancet ii: 303, 1985

    Google Scholar 

  118. Saxenhofer H, Gnädinger MP, Weidmann P, Shaw S, Schohn D, Hess C et al.: Plasma levels and dialysance of atrial natriuretic peptide in terminal renal failure. Kidney Int 32: 554, 1987

    PubMed  CAS  Google Scholar 

  119. Cannella G, Albertini A, Assanelli D, Ghielmi S, Poiesi C, Gaggiotti M et al.: Effects of changes in intravascular volume on atrial size and plasma levels of immunoreactive atrial natriuretic peptide in uremic man. Clin Nephrol 4: 187, 1988

    Google Scholar 

  120. Leunissen KML, Menheere PPCA, Cheriex EC, van den Berg BW, Noordzij TC, van Hooff JP: Plasma alphahuman atrial natriuretic peptide and volume status in chronic haemodialysis patients. Nephrol Dial Transplant 4: 382, 1989

    PubMed  CAS  Google Scholar 

  121. Thoren P, Mark AL, Morgan DA, O’Neill TP, Needleman P, Brody MJ: Activation of vagal depressor reflexes by atriopeptins inhibits renal sympathetic nerve activity. Am J Physiol 251: H1252, 1986

    PubMed  CAS  Google Scholar 

  122. Imaizumi T, Takeshita A, Higashi H, Nakamura M: a-ANP alters reflex control of lumbar and renal sympathetic nerve activity and heart rate. Am J Physiol 253: H1136, 1987

    PubMed  CAS  Google Scholar 

  123. Takeshita A: Effects of atrial natriuretic factor on baroreceptor reflexes. Hypertension 15: 168, 1990

    PubMed  CAS  Google Scholar 

  124. Floras JS: Sympathoinhibitory effects of atrial natriuretic factor in normal humans. Circulation 81:1860, 1990

    PubMed  CAS  Google Scholar 

  125. Muirhead EE, Pitcock J, Nasjletti A, Brown P, Brooks B: The antihypertensive function of the kidney. Hypertension 7(Suppl I): 1127, 1985

    Google Scholar 

  126. Losonczy Gy, Walter J, Mucha I, Taraba I: Changes of arterial prostaglandin E2 during haemodialysis. Nephrol Dial Transplant 5: 937, 1990

    PubMed  CAS  Google Scholar 

  127. Kishimoto T, Terada T, Okahara T, Abe Y, Yamagami S, Meakawa M: Correlations between blood prostaglandins and blood pressure in chronic renal failure. Nephron 47: 49, 1987

    PubMed  CAS  Google Scholar 

  128. O’Rourke MF: Arterial Function in Health and Disease, Edinburgh, Scotland, Churchill Livingstone Publisher, 1982, pp 94, 185

    Google Scholar 

  129. London GM, Marchais SJ, Safar ME, Genest AF, Guerin AP, Metivier F et al.: Aortic and large-artery compliance in end-stage renal failure. Kidney Int 37: 137, 1990

    PubMed  CAS  Google Scholar 

  130. Latham RD, Westerhof M, Sipkema P, Rubal BJ, Reuderink P, Murgo JP: Regional wave travel and reflections along human aorta: a study with six simultaneous micromanometric pressures. Circulation 72: 1257, 1985

    PubMed  CAS  Google Scholar 

  131. Kroeker EJ, Wood EH: Comparison of simultaneously recorded central and peripheral arterial pressure pulses during rest, exercise and tilted position in man. Circ Res 3: 623, 1955

    PubMed  CAS  Google Scholar 

  132. Burattini R. Knowlen GG, Campbell KB: Two arterial reflecting sites may appear as one to the heart. Circ Res 68: 85, 1991

    PubMed  CAS  Google Scholar 

  133. Kelly R, Hayward C, Avolio A, O’Rourke M: Noninvasive determination of age-related changes in the human arterial pulse. Circulation 80: 1652, 1989

    PubMed  CAS  Google Scholar 

  134. London GM, Guerin AP, Pannier B, Marchais SJ, Benetos A, Safar ME: Increased systolic pressure in chronic uremia: role of arterial wave reflections. Hypertension 20: 10, 1992

    PubMed  CAS  Google Scholar 

  135. Gow BS: Circulatory correlates: vascular impedance, resistance and capacity, in Handbook of Physiology Section 2, The Cardiovascular System, Vol. 2, edited by Bohr DF, Somlyo AP, Sparks HV Jr, Geiger SR, Amer Physiol Soc, Bethesda, 1980, p 353

    Google Scholar 

  136. Nichols WW, Avolio AP, Kelly RP, O’Rourke MF: Effects of age and hypertension on wave travel and reflections, in Arterial Vasodilation: Mechanisms and Therapy, editedy by O’Rourke M, Safar M, Dzau V, Edward Arnold Publisher, London, 1993 p 22

    Google Scholar 

  137. Gow BS, O’Rourke MF: Comparison of pressure and flow in the ascending aorta of different mammals. Proceedings, Australian Physiol and Pharmacol Soc 1970, P 1

    Google Scholar 

  138. London GM, Guerin AP, Pannier BM, Marchais SJ, Metivier F: Body height as a determinant of carotid pulse contour in humans. J Hypertens 10(Suppl 6): S93, 1992

    Google Scholar 

  139. Hsieh KY, O’Rourke MF, Avolio AP, Doherty JB, Kelly RP, Chen YT: Pressure wave contour in the ascending aorta of children: paradoxical similarity to the elderly. Aust NZ J Med 19:55, 1989

    Google Scholar 

  140. Christensen KL: Reducing pulse pressure in hypertension may normalize small artery structure. Hypertension 18: 722, 1990

    Google Scholar 

  141. Dame B, Girerd X, Safar M, Cambien F, Guize L: Pulsatile versus steady component of blood pressure: a crosssectional and prospective analysis of cardiovascular mortality. Hypertension 13: 392, 1989

    Google Scholar 

  142. SHEP cooperative research group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the systolic hypertension in the elderly program. J Am Med Assoc 17: 308, 1990

    Google Scholar 

  143. Piccoli G, Bonello F, Salomone M, Boero R. Piccoli GB, Bergia R et al.: Epidemiology of arterial blood pressure and hypertension in maintenance hemodialysis. in La Pression Arterielle chez l’Uremique, IX Symposium Gambro, Marseille, France, September 23–26, 1988, p 177

    Google Scholar 

  144. Simon P, Ang KS, Benziane A: Hypertension artérielle systolique isolée chez l’urémique chronique hémodialysé. Arch Mal Coeur 84: 1205, 1991

    PubMed  CAS  Google Scholar 

  145. Barenbrock M, Spieker C, Laske V, Baumgart P, Hoeks APG, Zidek W, Rahn KH: Effect of long-term hemodialysis on arterial compliance in end-stage renal failure. Nephron 65: 249, 1993

    PubMed  CAS  Google Scholar 

  146. Marchais SJ, Guerin AP, Pannier BM, Levy BI, Safar ME, London GM: Wave reflections and cardiac hypertrophy in chronic uremia: Influence of body size. Hypertension 22: 876, 1993

    PubMed  CAS  Google Scholar 

  147. Avolio AP, Deng FQ, Li DQ, Luo YF, Huang ZD, Xing LF, O’Rourke MF: Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71: 202, 1985

    PubMed  CAS  Google Scholar 

  148. Safar ME, Asmar RG, Benetos A, London GM, Levy BI: Sodium, large arteries and diuretic compounds in hypertension. J ofHypertens 10(Suppl 6): S133, 1992

    Google Scholar 

  149. London GM, Safar ME, Levy BI: Arterial compliance and effect of calcium antagonists, in Calcium Antagonists in Clinical Medicine, edited by Epstein M, Hanley & Belfus, Inc., Philadelphia, 1992, p 89

    Google Scholar 

  150. Marchais S, Guerin A, Safar M, London G: Arterial compliance in uraemia. J of Hypertens 7(Suppl 6): S84, 1989

    Google Scholar 

  151. Eschbach JW, Abdulhadi MH, Browne JK, Delano BG, Downing MR, Egrie JC et al.: Recombinant human erythropoietin in anemic patients with end-stage renal disease: results of a phase HI multicentre clinical trial. Ann Intern Med 111: 992, 1989

    PubMed  CAS  Google Scholar 

  152. Samtleben W, Baldamus CA, Bommer J, Fassbinder W, Nonnast-Daniel B, Gurland HJ: Blood pressure changes during treatment with recombinant human erythropoietin. Contrib Nephrol 66: 114, 1988

    PubMed  CAS  Google Scholar 

  153. Sundal E, Kaeser U: Correction of anemia of chronic renal failure with recombinant human erythropoietin: safety and efficacy of one year’s treatment in a European multicentre study of 150 haemodialysis-dependent patients. Nephrol Dial Transplant 4: 979, 1989

    PubMed  CAS  Google Scholar 

  154. Ishimitsu T, Tsukada H, Ogawa Y, Numabe A, Yagi S: Genetic predisposition to hypertension facilitates blood pressure elevation in hemodialysis patients treated with erythropoietin. Am J Med 94: 401, 1993

    PubMed  CAS  Google Scholar 

  155. Raine AEG: Seizures and hypertension events. Semin Nephrol 10(Suppl 1): 40, 1990

    PubMed  CAS  Google Scholar 

  156. Nonnast-Daniel B, Deschodt G, Brunkhorst R, Creutzig A, Bahlmann J, Shaldon S, Koch KM: Long-term effects of treatment with recombinant human erythropoietin on haemodynamics and tissue oxygenation in patients with renal failure. Nephrol Dial Transplant 5: 444, 1990

    PubMed  CAS  Google Scholar 

  157. Pascual J, Teruel JL, Liano F, Ortuno J: Decreased blood pressure after a year of erythropoietin. Nephron 58: 374, 1991

    Article  PubMed  CAS  Google Scholar 

  158. London GM, Zins B, Pannier B, Naret C, Berthelot JM, Jacquot C et al.: Vascular changes in hemodialysis patients in response to human recombinant erythropoietin. Kidney Int 36: 878, 1989

    PubMed  CAS  Google Scholar 

  159. Silberberg US, Racine N, Barre PE, Sniderman AD: Regression of left ventricular hypertrophy in dialysis patients following correction of anemia with recombinant human erythropoietin. Can J Cardiol 6: 1, 1990

    PubMed  CAS  Google Scholar 

  160. Abraham PA, Opsahl JA, Keshavian PR, Collins AJ, Whalen JJ, Asinger RW et al.: Body fluid spaces and blood pressure in hemodialysis patients during amelioration of anemia with erythropoietin. Am J Kidney Dis 14: 438, 1990

    Google Scholar 

  161. Hori K, Onoyama Y, Iseki K, Fujimi S, Fujishima M: Hemodynamic and volume changes by recombinant human erythropoietin (rHuEPO) in the treatment of anemic hemodialysis patients. Clin Nephrol 6: 293, 1990

    Google Scholar 

  162. Raine AEG, Roger SD: Effects of erythropoietin on blood pressure. Am J Kidney Dis 18(Suppl 1): 76, 1991

    PubMed  CAS  Google Scholar 

  163. Raine AEG: Hypertension, blood viscosity, and cardiovascular morbidity in renal failure: implications of erythropoietin therapy. Lancet 1: 97, 1988

    PubMed  CAS  Google Scholar 

  164. Steffen HM, Brunner R, Muller R Degenhardt S, Pollok M, Lang R, Baldamus CA: Peripheral hemodynamics, blood viscosity and renin-angiotensin system in hemodialysis patients under therapy with recombinant human erythropoietin. Contrib Nephrol 66: 114, 1988

    Google Scholar 

  165. Schaefer RM, Leschke M, Strauer BE, Heidland A: Blood rheology and hypertension in hemodialysis patients treated with erythropoietin. Am J Nephrol 8: 449, 1988

    PubMed  CAS  Google Scholar 

  166. Nonnast-Daniel B, Creutzig A, Kuhn K, Bahlmann J, Reimers E, Brunkhorst R et al.: Effect of treatment with human erythropoietin on peripheral hemodynamics and oxygenation. Contr Nephrol 66: 185, 1988

    CAS  Google Scholar 

  167. Roger SD, Grasty MS, Baker LRI, Raine AEG: Effects of oxygen breathing and erythropoietin on hypoxic vasodilation in uremic anemia. Kidney Int 42: 975, 1992

    PubMed  CAS  Google Scholar 

  168. Gill ML, Anderson JL: Erythropoietin-induceld hypertension without raising haematocrit. Nephrol Dial Transplant 8: 1264, 1993

    PubMed  CAS  Google Scholar 

  169. Bund SJ, Heagerty A, Edmunds M, Walls J: Erythropoietin does not induce vasoconstriction directly in human subcutaneous resistance arterioles. Nephron 53: 173, 1989

    PubMed  CAS  Google Scholar 

  170. Heidenreich S, Rahn KH, Zidek W: Direct vasopressor effect of recombinant human erythropoietin on renal resistance vessels. Kidney Int 39: 259, 1991

    PubMed  CAS  Google Scholar 

  171. Pagel H, Jelkmann W, Weiss C: Erythropoietin and blood pressure. Horm Metab Rev 21: 224, 1989

    CAS  Google Scholar 

  172. Jandeleit K, Heintz B, Gross-Heitfeld E, Kindler J, Sieberth HG, Kirsten R, Nelson K: Increased Activity of the autonomic nervous system and increased Sensitivity to angiotensin II infusion after therapy with recombinant human erythropoietin. Nephron 56: 220, 1990

    PubMed  CAS  Google Scholar 

  173. Roger SD, Baker LRI, Raine AEG: Autonomic dysfunction and the development of hypertension in patients treated with recombinant human erythropoietin (rHuEPO). Clin Nephrol 39: 103, 1993

    PubMed  CAS  Google Scholar 

  174. Carlini R, Obialo Ci, Rothstein S: Intravenous erythropoietin (rHuEPO) administration increases plasma endothelin and blood pressure in hemodialysis patients. A J Hypertens 6: 103, 1993

    CAS  Google Scholar 

  175. Anagnostou A, Lee ES, Kessimian N, Levinson R, Steiner M: Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 87: 5978, 1990

    PubMed  CAS  Google Scholar 

  176. Carlini RG, Dusso AS, Obialo CI, Alvarez UM, Rothstein M: Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial Cells. Kidney Int 43: 1010, 1993

    PubMed  CAS  Google Scholar 

  177. Gogusev J, Zhu DL, Marche P, Drucke T: Recombinant human erythropoietin (rHuEPO) stimulates rat vascular smooth muscle cell ( VSMC) growth in culture. J Am Soc Nephrol 4: 512, 1993 (abstract)

    Google Scholar 

  178. Wilcox CS, Deng X, Doll AH, Snellen H, Welch WJ: Nitric oxide mediates renal vasodilation during erythropoietin-inducedpolycythemia. Kidney Int 44: 430, 1993

    PubMed  CAS  Google Scholar 

  179. Collins P, Burman J, Chung HI, Fox K: Hemoglobin inhibits endothelium-dependent relaxation to acetylcholine in human coronary arteries in vivo. Circulation 87: 80, 1993

    PubMed  CAS  Google Scholar 

  180. Maynard JC, Cruz C, Kleerkoper M, Levin NW: Blood pressure response to changes in serum ionized calcium during hemodialysis. Ann Intern Med 104: 3518, 1986

    Google Scholar 

  181. Lang RM, Fellner SK, Neumann A, Bushinsky DA, Borow KM: Left ventricular contractility varies directly with blood ionized calcium. Ann Int Med 108: 524, 1988

    PubMed  CAS  Google Scholar 

  182. Fellner SK, Lang RM, Neumann A, Spencer KT, Bushinsky DA, Borow KM: Physiological mechanisms for calcium-induced changes in systemic arterial pressure in stable dialysis patients. Hypertension 13: 213, 1989

    PubMed  CAS  Google Scholar 

  183. Koren MJ, Devereux RB: Mechanisms, effects and reversal of left ventricular hypertrophy in hypertension. Current Opinion in Nephrol and Hypertension 2: 87, 1993

    CAS  Google Scholar 

  184. Parfrey PS: Cardiac and cerebrovascular disease in chronic uremia. Am J Kidney Dis 21: 77, 1993

    PubMed  CAS  Google Scholar 

  185. Ritz E, Fliser D: Hypertension and the kidney — an overview. Am J Kidney Dis 21(Suppl 3): 3, 1993

    PubMed  CAS  Google Scholar 

  186. Charra B, Calemard E, Cuche M, Laurent G: Control of hypertension and prolonged survival on maintenance hemodialysis. Nephron 33: 96, 1983

    PubMed  CAS  Google Scholar 

  187. Ritz E, Rambausek M, Mall G, Ruffmann K, Mandelbaum A: Cardiac changes in uraemia and their possible relationship to cardiovascular instability on dialysis. Nephrol Dial Transplant (Suppl 1): 93, 1990

    Google Scholar 

  188. Hamburger RJ, Christ Pg, Morris PA, Luft FC: Hypertension in dialysis patients: Does CAPD provide an advantage? Adv Perit Dial 5: 91, 1989

    PubMed  CAS  Google Scholar 

  189. Wehle B, Asaba H, Castenfors J, Furst P, Gunnarsson B, Shaldon S, Bergstrom J: Hemodynamic changes during sequential Ultrafiltration and dialysis. Kidney Int 14: 411, 1979

    Google Scholar 

  190. Maher JF: Pharmacological considerations for renal failure and dialysis, in Replacement of Renal Function by Dialysis, 3rd ed., edited by Maher J, Kluwer Academic Publishers, Dordrecht, 1989, p 1018

    Google Scholar 

  191. Marchais SJ, Boussac I, Guerin AP, Delavaux G, Metivier F, London GM: Arteriosclerosis and antihypertensive response to calcium antagonists in end-stage renal failure. J Cardiovasc Pharmacol 18(Suppl 1): S74, 1991

    Google Scholar 

  192. Guerin AP, Pannier BM, Marchais SJ, Metivier F, Safar M, London GM: Effects of antihypertensive agents on carotid pulse contour in humans. J of Human Hypertens 6(Suppl 2): S37, 1992

    Google Scholar 

  193. Ting CT, Chou CY, Chang MS, WAng SP, Chiang BN, Yin FCP: Arterial hemodynamics in human hypertension: effects of adrenergic blockade. Circulation 84: 1049, 1991

    PubMed  CAS  Google Scholar 

  194. Tielemans C, Madhoun P, Lenaers M, Schandene I, Goldman M, Vanherweghem JL: Anaphylactoid reactions during hemodialysis on AN69 membranes in patients receiving ACE inhibitors. Kidney Int 38: 982, 1990

    PubMed  CAS  Google Scholar 

  195. Pannier BM, Guerin AP, Marchais SJ, Cuche JL, Vicaut E, London GM: Amelioration pression independante de la distensibilite aortique chez l’hemodialyse hypertendu. Arch Mal Coeur 87: 1059, 1994

    PubMed  CAS  Google Scholar 

  196. Hulter HN, Licht JH, Ilnicki LP, Singh S: Clinical efficacy and pharmacokinetics of clonidine in hemodialysis and renal insufficiency. J Lab Clin Med 94: 223, 1979

    PubMed  CAS  Google Scholar 

  197. Harter HR, Delmez JA: Effects of prazosin on the control of blood pressure in hypertensive dialysis patients. J Cardiovasc Pharmacol (Suppl 1): S43, 1979

    Google Scholar 

  198. Keusch G, Schifft H, Binswanger U: Diazoxide and labetalol in acute hypertension during hemodialysis. Eur J Clin Pharmacol 25: 523, 1983

    PubMed  CAS  Google Scholar 

  199. Daugirdas JG: Dialysis hypotension: A hemodynamic analysis. Kidney Int 39: 233, 1991

    PubMed  CAS  Google Scholar 

  200. Bergström J, Asaba H, Furst P: Dialysis ultrafiltration and blood pressure. Proc Eur Dial Transplant Assoc 13: 293, 1976

    Google Scholar 

  201. Henderson LW, Koch KM, Dinarello CA, Shaldon S: Hemodialysis hypotension: the interleukin hypothesis. Blood Purif 1:3, 1988

    Google Scholar 

  202. Guyton AC, Coleman TG, Granger HJ: Circulation: Overall regulation. Ann Rev Physiol 34: 13, 1972

    CAS  Google Scholar 

  203. Gauer OH, Henry JP: Neurohumoral control of plasma volume, in Cardiovascular Physiology II, International Review of Physiology, edited by Guyton AC, Cowley AW Jr, Baltimore, University Park Press, 1976 vol 9, p 145

    Google Scholar 

  204. Echt M, Duweling J, Gauer OH, Lange L: Effective compliance of the total vascular bed and the intrathoracic compartment derived from changes in central venous pressure induced by volume changes in man. Circ Res 34:61, 1974

    Google Scholar 

  205. Rothe CF: Venous system: physiology of the capacitance vessels, in Handbook ofPhysiology, Section 2 Cardiovascular System, Vol. 3, Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Am Physiol Soc, Bethesda, 1983, p 397

    Google Scholar 

  206. Greenway CV, Seaman KL, Innes IR: Effect of Norepinephrine on venous compliance and unstressed volume in cat liver. Am J Physiol 248: H468, 1985

    PubMed  CAS  Google Scholar 

  207. Bennett TD, Wyss CR, Scher AM: Changes in vascular capacity in awake dogs in response to carotid sinus occlusions and administration of catecholamines. Circ Res 55: 440, 1984

    PubMed  CAS  Google Scholar 

  208. Hirsch AT, Levenson DJ, Cuttler SS, Dzau VJ, Creager MA: Regional vascular responses to prolonged lower body negative pressure in normal subjects. Am J Physiol 257: H219, 1989

    PubMed  CAS  Google Scholar 

  209. Rothe CF: Reflex control of veins and vascular capacitance. Physiol Rev 63: 1281, 1983

    PubMed  CAS  Google Scholar 

  210. Johnson JM, Rowell LB, Niederberger M, Eisman MM: Human splanchnic and forearm vasoconstrictor response to reductions in right atrial and aortic pressure. Circ Res 34:515, 1974

    PubMed  CAS  Google Scholar 

  211. Abboud FM, E1ckberg DL, Johannsen UJ, Mark AL: Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vascular resistance during venous pooling in man. J Physiol 286: 173, 1979

    PubMed  CAS  Google Scholar 

  212. Victor RG, Leimbach WN Jr: Effects of lower body negative pressure on sympathetic discharge to leg muscle in humans. J Appl Physiol 63: 2558, 1987

    PubMed  CAS  Google Scholar 

  213. Michel CC: Fluid movements through capillary walls, in Handbook of Physiology, Section 2, The Cardiovascular System, Vol. 4 Microcirculation, A Physiol Soc, Bethesda, 1984, p 375

    Google Scholar 

  214. Koomans HA, Geers AB, Dorhout Mees EJ: Plasma volume recovery after ultrafiltration in patients with chronic renal failure. Kidney Int 26: 848, 1984

    PubMed  CAS  Google Scholar 

  215. Geers AB, Koomans HA, Roos JC, Dorhout Mees EJ: Preservation of blood volume during edema removal in nephrotic subjects. Kidney Int 28: 652, 1985

    PubMed  CAS  Google Scholar 

  216. Leunissen KML, Noordzij TC, van Hoff JP: Pathophysiologic aspects of plasma volume preservation. Contrib Nephrol 78: 201, 1990

    PubMed  CAS  Google Scholar 

  217. Daugirdas JT, Nawab ZM: Acetate relaxation in isolated vascular smooth muscle. Kidney Int 32: 39, 1987

    PubMed  CAS  Google Scholar 

  218. Nutting CW, Islam S, Ye M, Batlle DC, Daugirdas JT: The vasorelaxant effects of acetate: role of adenosine, glycolysis, Iyotropism, and pHi and Cai++. Kidney Int 41: 166, 1992

    PubMed  CAS  Google Scholar 

  219. Fleming SJ, Wilkinson JS, Greenwood RN, Aldridge C, Baker LRI, Cattel WR: Effect of dialysate composition on intercompartment fluid shift. Kidney Int 32: 267, 1987

    PubMed  CAS  Google Scholar 

  220. Graefe U, Milutinovitch J, Follette WC, Vizzo JE, Babb AL, Scribner BH: Improved tolerance to rapid ultrafiltration with the use of bicarbonate in dialysate. Proc Eur Dial Transplant Assoc 14: 153, 1977

    PubMed  CAS  Google Scholar 

  221. Hsu CH, Swartz RD, Somermeyer MG, Raj A: Bicarbonate hemodialysis: influence on plasma refilling and hemodynamic stability. Nephron 38: 202, 1984

    PubMed  CAS  Google Scholar 

  222. de Vries PMJM, Olthof CG, Solf A, Schuenemann B, Oe PL, Quellhorst E et al.: Fluid balance during haemodialysis and haemofiltration: the effect of dialysate sodium and a variable ultrafiltration rate. Nephrol Dial Transplant 6: 257, 1991

    PubMed  Google Scholar 

  223. Kouw PM, Olthoff CG, ter Wee PM, Oe LP, Donker AJM, Schneider H, de Vries PMJM: Assessment of postdialysis dry weight: an application of the conductivity measurement method. Kidney Int 41: 440, 1992

    PubMed  CAS  Google Scholar 

  224. Schneditz D, Roob J, Oswald M, Pogglitsch H, Moser M, Kenner T, Binswanger U: Nature and rate of vascular refilling during hemodialysis and ultrafiltration. Kidney Int 42: 1425, 1992

    PubMed  CAS  Google Scholar 

  225. de Vries JPPM, Kouw PM, van der Meer NJM, Olthof CG, Oe LP, Donker AJM, de Vries PMJM: Non-invasive monitoring of blood volume during hemodialysis: its relation with post-dialytic dry weight. Kidney Int 44: 851, 1993

    PubMed  Google Scholar 

  226. Kooman JP, Gladziwa U, Bocker G, van Bortel LMAB, van Hoof JP, Leunissen KML: Role of the venous system in hemodynamics during ultrafiltration and bicarbonate dialysis. Kidney Int 42: 718, 1992

    PubMed  CAS  Google Scholar 

  227. Bradley JR, Evans DB, Cowley AJ: Comparison of vascular tone during combined haemodialysis with ultrafiltration and during ultrafiltration followed by haemodialysis: a possible mechanism for dialysis hypotension. Br Med J 300: 1312, 1990

    CAS  Google Scholar 

  228. Nakamura Y, Ikeda T, Takata S, Yokoi H, Hirono M, Abe T et al.: The role of peripheral resistance and capacitance vessels in hypotension following hemodialysis. Am Heart J 121: 1170, 1991

    PubMed  CAS  Google Scholar 

  229. Grossman W, McLaurin LP: Diastolic properties of the left ventricle. Ann Intern Med 84: 316, 1991

    Google Scholar 

  230. Hutting J, Kramer W, Schutterle G, Wizemann V: Analysis of left-ventricular changes associated with chronic hemodialysis: a noninvasive follow-up study. Nephron 49: 284, 1988

    Google Scholar 

  231. Sanders JS, Ferguson DW: Profound sympathoinhibition complicating hypovolemia in humans. Ann Intern Med 111:439, 1989

    PubMed  CAS  Google Scholar 

  232. Mark AL: The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart. J Am Coll Cardiol 1:90, 1983

    Article  PubMed  CAS  Google Scholar 

  233. Vizemann V, Kramer W: Choice of ESRD treatment strategy according to cardiac status. Kidney Int 33(Suppl 24): S191, 1988

    Google Scholar 

  234. Nixon JV, Mitchell JH, McPhaul JJ, Henrich WL: Effect of hemodialysis on left ventricular function. Dissociation of changes in filling volume and in contractile state. J Clin Invest 71: 377, 1983

    PubMed  CAS  Google Scholar 

  235. Levy FL, Grayburn PA, Foulks CJ, Brickner ME, Henrich WL: Improved left ventricular contractility with cool temperature hemodialysis. Kidney Int 41: 961, 1992

    PubMed  CAS  Google Scholar 

  236. Hakim RM, Pontzer MA, Lazarus MJ, Gottlieb M: Effects of acetate and bicarbonate dialysate in stable chronic dialysis patients. Kidney Int 28: 535, 1985

    PubMed  CAS  Google Scholar 

  237. Mehta BR, Fischer D, Ahmad M, Dubose TD: Effects of acetate and bicarbonate hemodialysis on cardiac function in chronic dialysis patients. Kidney Int 24: 782, 1983

    PubMed  CAS  Google Scholar 

  238. Anderson LE, Nixon JV, Henrich WL: Effects Of acetate and bicarbonate dialysate on left ventricular performance. Am J Kidney Dis 10: 350, 1987

    PubMed  CAS  Google Scholar 

  239. Trimarco B, Lembo G, Deluca N, Volpe M, Ricciardelli B, Condorelli G et al.: Blunted sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy. A possible compensatory role of atrial natriuretic factor. Circulation 80: 883, 1989

    PubMed  CAS  Google Scholar 

  240. Soriano G, Eisinger R: Abnormal response to Valsalva manoeuvre in patients on chronic haemodialysis. Nephron 9: 251, 1972

    Article  PubMed  CAS  Google Scholar 

  241. Kersh E, Kronfield J, Unger A, Popper R, Cantor S, Cohn K: Autonomic insufficiency as a cause of haemodialysis-induced hypotension. New Engl J Med 290: 650, 1974

    Article  PubMed  CAS  Google Scholar 

  242. Nies A, Robertson D, Stone W: Haemodialysis hypotension is not the result of uraemic peripheral neuropathy. J Lab Clin Med 94: 395, 1979

    PubMed  CAS  Google Scholar 

  243. Zoccali C, Ciccarelli M, Maggiore Q: Defective reflex control of heart rate in dialysis patients. Evidence for an afferent autonomic lesion. Clin Sci 63: 285, 1982

    PubMed  CAS  Google Scholar 

  244. Chaignon M, Chen WT, Tarazi RC, Nakamoto S, Bravo EL: Blood pressure response to hemodialysis. Hypertension 3:333, 1981

    PubMed  CAS  Google Scholar 

  245. Nakashima Y, Fouad FM, Nakamoto S, Textor CS, Bravo EL, Tarazi RC: Localization of autonomic nervous system dysfunction in dialysis patients. Am J Nephrol 7: 735, 1987

    Article  Google Scholar 

  246. Odar-Cederlof I, Theodorsson E, Eriksson E, Hamberger B, Tidgren B, Kjellstrand CM: Vasoactive agents and blood pressure regulation in sequential ultrafiltration and hemodialysis. Int J Artif Organs 16: 662, 1993

    PubMed  CAS  Google Scholar 

  247. Fox SD, Henderson LW: Cardiovascular response during hemodialysis and hemofiltration — thermal, membrane, and catecholamine influence. Blood Purificat 11: 224, 1993

    Article  CAS  Google Scholar 

  248. Heintz B, Konigs F, Dakshinamurty KV. Kierdorf H, Gladziwa U, Kirsten R et al.: Response of vasoactive substances to intermittent ultrafiltration in normotensive hemodialysis patients. Nephron 65: 266, 1993

    PubMed  CAS  Google Scholar 

  249. Heintz B, Reiners K, Gladziwa U, Kirsten R, Nelson K, Wieland D et al.: Response of vasoactive substances to reduction of blood volume during hemodialysis in hypotensive patients. Clin Nephrol 39: 198, 1993

    PubMed  CAS  Google Scholar 

  250. Sorensen SS, Danielsen H, Jespersen B, Pedersen EB: Hypotension in end-stage renal disease: effect of postural changes, exercise and angiotensin II infusion on blood pressure and plasma concentrations of angiotensin II, aldosterone and arginine vasopressin in hypotensive patients with chronic renal failure treated by dialysis. Clin Nephrol 26:288, 1986

    PubMed  CAS  Google Scholar 

  251. Moore TJ, Lazarus M, Hakim RM: Reduced angiotensin receptors and pressor response in hypotensive hemodialysis patients. Kidney Int 26: 288, 1986

    Google Scholar 

  252. Odar-Cederlof I, Theodorsson E, Eriksson CG, Kjellstrand CM: Plasma concentrations of calcitonin gene-related peptide increase during haemodialysis: relation to blood pressure. J Intern Med 226: 177, 1989

    PubMed  CAS  Google Scholar 

  253. Maggiore Q, Pizzarelli F, Zoccali C, Sisca S, Nicolo F, Parlongo S: Effect of extracorporeal blood cooling on dialytic arterial hypotension. Proc Eur Dial Transplant Assoc 18: 597, 1981

    PubMed  CAS  Google Scholar 

  254. Roddie IA: Circulation to skin and adipose tissue, in Handbook of Physiology, Section 2, The Cardiovascular System, Vol. 3, Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Geiger SR (eds), Am Physiol Soc, Bethesda, 1983, p 285

    Google Scholar 

  255. Mahida BH, Dumler F, Zasuwa G, Fleig G, Levin NW: Effect of cooled dialysate on serum catecholamine and pressure stability. Trans Am Soc Artif Intern Organs 29: 384, 1983

    PubMed  CAS  Google Scholar 

  256. Maggiore Q, Pizzarelli F, Sisca S, Catalano G, Delfino D: Vascular stability and heat in dialysis patients. Clin Nephrol 41: 398, 1984

    CAS  Google Scholar 

  257. Sherman RA, Rubin MP, Cody RP, Eisinger RP: Amelioration of hemodialysis-associated hypotension by the use of cool dialysate. Am J Kidney Dis 5: 124, 1986

    Google Scholar 

  258. Jost CMT, Agarwal R, Khair-el-Din T, Grayburn PA, Victor RG, Henrich WL: Effects of cooler temperature dialysate on hemodynamic stability in ‘problem’ dialysis patients. Kidney Int 44: 606, 1993

    PubMed  CAS  Google Scholar 

  259. Sherman RA, Torres F, Cody RP: Postprandial blood pressure changes during hemodialysis. Am J Kidney Dis 12: 37, 1988

    PubMed  CAS  Google Scholar 

  260. Zoccali C, Mallamaci F, Ciccarelli M, Maggiore Q: Postprandial alterations in arterial pressure control during hemodialysis in uremic patients. Clin Nephrol 31: 323, 1989

    PubMed  CAS  Google Scholar 

  261. Donald DE: Splanchnic circulations, in Handbook of Physiology, Section 2, The Cardiovascular System, Vol. 3, Peripheral Circulation and Organ Blood Flow, edited by Shepherd JT, Abboud FM, Geiger SR, Am Physiol Soc, Bethesda, 1983, p 219

    Google Scholar 

  262. Onrot J, Goldberg MR, Biagioni I, Hollister AS, Kingaid D, Robertson D: Hemodynamic and humoral effects of caffeine in autonomic failure. Therapeutic implications for postprandial hypotension. New Engl J Med 313: 549, 1985

    Article  PubMed  CAS  Google Scholar 

  263. Herbelin A, Nguyen AT, Zingraff J, Urena P, Descamps-Latcha B: Influence of uremia and hemodialysis on circulating interleukin-1 and tumor necrosis factor a. Kidney Int 37: 116, 1990

    PubMed  CAS  Google Scholar 

  264. Chenoweth DE, Cheung AK, Henderson LW: Anaphylatoxin formation during hemodialysis. Effects of different hemodialyzer membranes. Kidney Int 24: 764, 1983

    PubMed  CAS  Google Scholar 

  265. Bingel N, Lonnemann G, Koch KM, Dinarello CA, Shaldon S: Enhancement of in-vitro human interleukin-1 production by sodium acetate. Lancet 1:14, 1987

    PubMed  CAS  Google Scholar 

  266. Laude-Sharp M, Caroff M, Simard L, Pusineri C, Kazatchkine MD, Haeffner-Cavaillon N: Induction of IL-1 during hemodialysis: transmembrane passage of intact endotoxin(LPS). Kidney Int 38: 1089, 1990

    PubMed  CAS  Google Scholar 

  267. Beasley D, Brenner BM: Role of nitric oxide in hemodialysis hypotension. Kidney Int 42(Suppl 38): S96, 1992

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

C. Jacobs C. M. Kjellstrand K. M. Koch J. F. Winchester

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

London, G., Marchais, S., Guerin, A.P. (1996). Blood Pressure Control in Chronic Hemodialysis Patients. In: Jacobs, C., Kjellstrand, C.M., Koch, K.M., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-36947-1_38

Download citation

  • DOI: https://doi.org/10.1007/978-0-585-36947-1_38

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-3610-5

  • Online ISBN: 978-0-585-36947-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics