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Pregnancies in Women on Renal Replacement Therapy

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Replacement of Renal Function by Dialysis

Abstract

Successful pregnancy in a woman on renal replacement therapy (RRT) is an impressive demonstration of physiological well-being and emotional rehabilitation. It has been reported on more than a thousand occasions in women with functioning transplants, but far less frequently in those on haemodialysis and peritoneal dialysis

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References

  1. Murray JE, Reid DE, Harrison JH, Merrill JP: Successful pregnancies after human renal transplantation. New Engl J Med 269: 341, 1963

    Article  PubMed  CAS  Google Scholar 

  2. Board JA, Lee HM, Draper DA, Hume DM: Pregnancy following kidney homo-transplantation from a non-twin. Obstet Gynecol 29: 318, 1967

    PubMed  CAS  Google Scholar 

  3. Kaufman JJ, Dignam W, Goodwin WE, Martin DC, Goldman R, Maxwell MH: Successful normal childbirth after kidney homo-transplantation. JAMA 200: 162, 1967

    Article  Google Scholar 

  4. Caplan RM, Dossetor JB, Maughan GB: Pregnancy following cadaver kidney homo-transplantation. Am J Obstet Gynecol 106: 644, 1970

    PubMed  CAS  Google Scholar 

  5. Gevers RH, Hintzen AHJ, Kalff MW et al.: Pregnancy following kidney transplantation. Eur J Obstet Gynaecol 1: 147, 1971

    Article  Google Scholar 

  6. Horbach J, Van Liebergen F, Mastboom J, Wijdeveld P: Pregnancy in a patient after cadaveric renal transplantation. Acta Med Scand 194: 237, 1973

    Article  PubMed  CAS  Google Scholar 

  7. Robertson JG, Cockbum F, Woodruff M: Successful pregnancy after cadaveric renal transplantation. J Obstet Gynaecol Br Commonw 81: 777, 1974

    PubMed  CAS  Google Scholar 

  8. Jacob ET, Grunstein S, Shapira Z, Berant M, Better OS, Boner G: Successful pregnancy in a recipient of a cadaver kidney allograft. Isr J Med Sci 10: 206, 1974

    CAS  Google Scholar 

  9. Merkatz IR, Schwartz GH, David DS, Stenzel KH, Riggio RR, Whitsell JC: Resumption of female reproductive function following renal transplantation. JAMA 216: 1949, 1971

    Article  Google Scholar 

  10. Merrill LK, Board JA, Lee HM: Complications of pregnancy after renal transplantation including a report of spontaneous uterine rupture. Obstet Gynecot 41: 270, 1973

    CAS  Google Scholar 

  11. Penn I, Makowski EL, Harris P: Parenthood following renal transplantation. Kidney Int 18: 221, 1980

    Article  PubMed  CAS  Google Scholar 

  12. Sciarra JJ, Toledo-Preyra LH, Bendel RP, Simmons RL: Pregnancy following renal transplantation. Am J Obstet Gynecol 123: 411, 1975

    PubMed  CAS  Google Scholar 

  13. Golby M: Fertility after renal transplantation. Transplantation 10: 201, 1970

    Article  PubMed  CAS  Google Scholar 

  14. Nolan GH, Sweet RL, Laros RK, Roure CA: Renal cadaver transplantation followed by successful pregnancies. Obstet Gynecol 43: 732, 1974

    PubMed  CAS  Google Scholar 

  15. Rifle G, Traeger J: Pregnancy after renal transplantation: an international survey. Transplant Proc 7(Suppl 1): 723, 1975

    Google Scholar 

  16. Davison JM: Renal transplantation and pregnancy. Am J Kidney Dis 9: 374, 1987

    PubMed  CAS  Google Scholar 

  17. Armenti VT, Ahlswede KM, Ahlswede BA, Jarrell BE, Moritz MJ, Burke JF: National Transplant Registry: outcomes of 154 pregnancies in Cyclosporine-treated female kidney transplant recipients. Transplantation 57: 502, 1994

    Article  PubMed  CAS  Google Scholar 

  18. Confortini P, Galanti G, Ancona G, Giongo A, Bruschi E, Lorenzini E: Full term pregnancy and successful delivery in a patient on chronic haemodialysis. in Proceedings of the European Dialysis and Transplant Association, edited by Cameron JS, Pitman Medical, London, 1971, p 74

    Google Scholar 

  19. Unzelman RF, Alderfer GR, Chojnacki RE: Pregnancy and chronic hemodialysis. Trans Am Soc Artif Intern Organs 19: 144, 1973

    PubMed  CAS  Google Scholar 

  20. Ackrill P, Goodwin FJ, Marsh FP, Stratton D, Wagman H: Successful pregnancy in patients on regular dialysis. Br Med J 2: 172, 1975

    PubMed  CAS  Google Scholar 

  21. Rigenbach M, Renger B, Beauvais P, Imbs JF, Eschbach J, Frey G: Grossesse et accouchement d’un enfant vivant chez une patiente traitée par hémodialyse iterative. J Urol Nephrol (Paris) 84: 360, 1978

    Google Scholar 

  22. Registration Committee of the European Dialysis and Transplant Association: Successful pregnancies in women treated by dialysis and kidney transplantation. Br J Obstet Gynaecol 87: 839, 1980

    Google Scholar 

  23. Challah S, Wing AJ, Broyer M, Rizzoni G: Successful pregnancies in women on regular dialysis treatment and women with a functioning transplant. in The Kidney in Pregnancy, edited by Andreucci VE, Amsterdam, Martinus Nijhoff, 1986, p 185

    Google Scholar 

  24. Rizzoni G, Enrich JH, Broyer M et al.: Successful pregnancies in women on renal replacement therapy: report from the EDTA Registry. Nephrol Dial Transplant 7: 279, 1992

    PubMed  CAS  Google Scholar 

  25. Souqiyyeh MZ, Huraib SO, Mohd. Saleh AG et al.: Pregnancy in chronic hemodialysis patients in the kingdom of Saudi Arabia. Am J Kidney Dis 19: 235, 1992

    PubMed  CAS  Google Scholar 

  26. Hou SH: Frequency and outcome of pregnancy in women on dialysis. Am J Kidney Dis 23: 60, 1994

    PubMed  CAS  Google Scholar 

  27. Hou S: Pregnancy and birth control in dialysis patients. Dial Transplant 23: 22, 1994

    Google Scholar 

  28. Hou S, Grossman SD: Pregnancy in chronic dialysis patients. Seminars in Dialysis 3: 224, 1990

    Article  Google Scholar 

  29. Gruenfeld JP, Ganeval D, Bournerias F: Acute renal failure in pregnancy. Kidney Int 18: 179, 1980

    Article  Google Scholar 

  30. Cattaneo AA, Belghiti D, Milliez J, Plovin PF, Sobel AT: Renin, hypertension et grossesse, III: risque des nephropathies au cours de la grossese. Nouv Presse Med 11: 1791, 1982

    PubMed  CAS  Google Scholar 

  31. Naik RB, Clark AD, Warren DT: Acute proliferative glomerulonephritis with crescents and renal failure in pregnancy successfully managed by intermittent haernodialysis: case report. Brit J Obstet Gynaecol 86: 819, 1979

    CAS  Google Scholar 

  32. Leader L, Strasburg ER, Baillie P, Keeton RD: Haemodialysis in pregnancy: a case report. S African Med J 53: 871, 1978

    CAS  Google Scholar 

  33. Cole EH, Bear RA, Steinberg W: Acute renal failure at 24 weeks of pregnancy: a case report. Can Med Assoc J 122: 1161, 1980

    PubMed  CAS  Google Scholar 

  34. Hensel A, Pauls A, von Herrath D, Schaefer K: Successful hemodialysis for acute renal failure in late pregnancy. Am J Nephrol 2: 98, 1982

    PubMed  CAS  Google Scholar 

  35. Kopsa H, Schmidt P, Friedrich F et al.: Spontangeburt eines lebensfahigen Kindes bei erfolgreicher Haernodialy-sebehandlung einer Schwangerschafts-pyelonephritis mit akuter Oligo-anurie. Schweiz Med Wochenschr 108: 999, 1978

    PubMed  CAS  Google Scholar 

  36. Cattran DC, Benzie RJ: Pregnancy in a continuous ambulatory peritoneal dialysis patient. Peritoneal Dial Bull 3: 13, 1983

    Google Scholar 

  37. Kioki EM, Shaw KM, Clarke AD et al.: Successful pregnancy in a diabetic patient treated with continuous ambulatory peritoneal dialysis. Diabetes Care 6: 298, 1983

    Article  Google Scholar 

  38. Jakobi P, Ohel G, Szylman P et al.: Continuous ambulatory peritoneal dialysis as the primary approach in the management of severe renal insufficiency in pregnancy. Obstet Gynecol 79: 808, 1992

    PubMed  CAS  Google Scholar 

  39. Lau J, Scott JR: Pregnancy following renal transplantation. Clin Obstet Gynecol 28: 339, 1985

    Article  PubMed  CAS  Google Scholar 

  40. Geerlings W, Tufveson G, Brunner FP et al.: Combined report on regular dialysis and transplantation in Europe, XXI, 1990. Nephrol Dial Transplant 6(Suppl 4): 5, 1991

    Google Scholar 

  41. Armenti VT, Ahlswede KM, Ahlswede BA, Miortiz MJ, Jarre BE, Burke JF: The National Transplantation Pregnancy Registry: an analysis of 325 pregnancies in female kidney recipients. J Am Soc Nephrol 3: 851, 1991

    Google Scholar 

  42. Armenti VT, Ahlswede BA, Moritz MJ, Jarrell BE: The National Transplantation Pregnancy Registry: analysis of pregnancy outcomes of female kidney recipients with relation to time interval from transplant to conception. Transplant Proc 25: 1036, 1993

    PubMed  CAS  Google Scholar 

  43. Rudolph JE, Schweizer RT, Bartus SA: Pregnancy in renal transplant patients. Transplantation 26: 27, 1979

    Google Scholar 

  44. Walters BNJ, Redman CWG: Treatment of severe pregnancy-associated hypertension with the calcium antagonist nifedipine. Br J Obstet Gynaecol 91: 330, 1984

    PubMed  CAS  Google Scholar 

  45. Constantine G, Beevers DG, Reynolds AL el al.: Nifedipine as a second line antihypertensive drug in pregnancy. Br J Obstet Gynaecol 94: 1136, 1987

    PubMed  CAS  Google Scholar 

  46. Ferris TF, Weir EK: Effect of captopril on uterine blood flow and prostaglandin E synthesis in the pregnant rabbit. J Clin Invest 71: 809, 1983

    PubMed  CAS  Google Scholar 

  47. 47. Anon: Are ACE inhibitors safe in pregnancy? Lancet 2: 482, 1989

    Google Scholar 

  48. Conrad M, Barton JC: Factors affecting iron balance. Am J Hematol 10: 199, 1991

    Article  Google Scholar 

  49. Mitwalli A, Malik GH, Fayed H et al.: Erythropoietin therapy in a pregnant woman on maintenance haemodialysis. Saudi J Kidney Dis Transplant 5(4): 489, 1994

    CAS  Google Scholar 

  50. Davison JM: Dialysis, Transplantation and pregnancy. Am J Kidney Dis 17: 127, 1991

    PubMed  CAS  Google Scholar 

  51. Fujumi S, Hori K, Mijima C, Shigematsu M: Successful pregnancy and delivery in a patient following r-HuEPO therapy and on long term dialysis. J Am Soc Nephrol 1: 397, 1990

    Google Scholar 

  52. Yankowitz J, Piraino B, Laifer SA et al.: Erythropoietin in pregnancies complicated by severe anemia of renal failure. Obstet Gynecol 80: 485, 1992

    PubMed  CAS  Google Scholar 

  53. Hou S, Orlowski J, Pahl M, Ambrose S, Hussey M, Wong D: Pregnancy in woman with end stage renal disease: treatment of anemia and premature labour. Am J Kidney Dis 21: 16, 1993

    PubMed  CAS  Google Scholar 

  54. 54. Anon: Erythropoietin for anemia. Med Lett Drugs Ther 31: 85, 1989

    Google Scholar 

  55. Redrow M, Cherem L, Elliot J et al.: Dialysis in the management of patients with renal insufficiency. Medicine 67: 199, 1988

    Article  PubMed  CAS  Google Scholar 

  56. Pickrell MD, Sawyers R, Michael J: Pregnancy after renal transplantation: severe intrauterine growth retardation during treatment with cyclosporin A. Br Med J 296: 825, 1988

    Article  CAS  Google Scholar 

  57. Lindheimer MD, Katz AI: Pregnancy in the renal transplant patient. Am J Kidney Dis 19: 173, 1992

    PubMed  CAS  Google Scholar 

  58. Raine AEG, Margreiter R, Brunner FP et al.: Report on management of renal failure in Europe, XXII, 1991. Nephrol Dial Transplant 7(Suppl 2): 7, 1993

    Google Scholar 

  59. Legrain M: Transplantation renalé et grossesse. Gynecologie 27: 535, 1976

    Google Scholar 

  60. Wing AJ, Davies DV: Acute post-partum renal failure in a renal transplant recipient. Unpublished

    Google Scholar 

  61. Davison JM: The effect of pregnancy on kidney function in renal allograft recipients. Kidney Int 27: 74, 1985

    Article  PubMed  CAS  Google Scholar 

  62. Baylis C, Reckelhoff JF: Renal hemodynamics in normal and hypertension pregnancy: lessons from micropuncture. Am J Kidney Dis 17: 98, 1991

    PubMed  CAS  Google Scholar 

  63. Baylis C, Rennke HG: Renal hemodynamics and glomerular morphology in repetitive pregnant ageing rats. Kidney Int 28: 140, 1985

    Article  PubMed  CAS  Google Scholar 

  64. Salmela K, Kylloenen L, Holmberg C: Renal transplantation and parenthood. Transplantation Proceedings 24: 1744, 1992

    PubMed  CAS  Google Scholar 

  65. Salmela K, Kylloenen L, Holmberg et al.: Influence of pregnancy on kidney graft function. Transplant Proc 25: 1302, 1993

    PubMed  CAS  Google Scholar 

  66. Sturgiss SN, Davison JM: Effect of pregnancy on long-term function of renal allografts. Am J Kidney Dis 19: 167, 1992

    PubMed  CAS  Google Scholar 

  67. Sturgiss SN, Davison JM: Perinatal outome in renal allograft recipients: prognostic significance of hypertension and renal function before and during pregnancy. Obstet Gynecol 573, 1991

    Google Scholar 

  68. Davison JM: The effect of pregnancy on kidney function in renal allograft recipients. Kidney Int 27: 74, 1985

    Article  PubMed  CAS  Google Scholar 

  69. Brenner BM, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of glomerular sclerosis in ageing, renal ablation and intrinsic renal disease. N Engl J Med 307: 652, 1982

    Article  PubMed  CAS  Google Scholar 

  70. Katz AI, Lindheimer MD: Does pregnancy aggravate primary glomerular disease? Am J Kidney Dis 6: 261, 1985

    PubMed  CAS  Google Scholar 

  71. Davison JM: Pregnancy in renal transplant recipients: clinical perspectives. Contrib Nephrol 37: 170, 1984

    PubMed  CAS  Google Scholar 

  72. Pahl MV, Vaziri ND, Kaufman DJ et al.: Childbirth after renal transplantation. Transplant Proc 25: 2727, 1993

    PubMed  CAS  Google Scholar 

  73. Gallery ED: Pregnancy in women with renal transplants. (Editorial) Int J Artif Organs 12: 141, 1989

    PubMed  CAS  Google Scholar 

  74. Ehrich JHH, Rizzoni G, Broyer et al.: Combined report on regular dialysis and transplantation of children in Europe, 1987. Nephrol Dial Transplant 4(Suppl 2): 33, 1989

    Google Scholar 

  75. Lubchenco LO, Hansman C, Dressier M, Boyd E: Intrauterine growth as estimated from liveborn birth-weight: data at 24 to 42 weeks of gestation. Pediatrics 32: 793, 1963

    PubMed  CAS  Google Scholar 

  76. Ehrich JHH, Rizzoni G, Brunner FP et al.: Combined report on regular dialysis and transplantation of children in Europe, 1989. Nephrol Dial Transplant 6(Suppl 1): 37, 1991

    PubMed  Google Scholar 

  77. Ehrich JHH, Loirat C, Rizzoni G et al.: Repeated successful pregnancies after kidney transplantation in 102 women; report by the EDTA-ERA Registry. Unpublished

    Google Scholar 

  78. Koops B, Morgan L, Battaglia F: Neonatal mortality risk in relation to birth-weight and gestational age. J Pediatr 101:969, 1982

    Article  PubMed  CAS  Google Scholar 

  79. Price HV, Salaman JR, Laurence KM, Langmaid H: Immunosuppressive drugs and the foetus. Transplantation 21:294, 1976

    Article  PubMed  CAS  Google Scholar 

  80. Leb DE, Weisskopf B, Kawovitz BS: Chromosome aberrations in the child of a kidney transplant recipient. Arch Intern Med 128: 441, 1971

    Article  PubMed  CAS  Google Scholar 

  81. Githens JH, Rosenkrantz JG, Tunnock SM: Teratogenic effects of azathioprine (Imuran). J Pediatr 66: 959, 1965

    Article  PubMed  CAS  Google Scholar 

  82. Evans TJ, McCollum JPK, Valdimarsson H: Congenital cytomegalovirus infection after maternal renal transplantation. Lancet 1: 1359, 1975

    Article  PubMed  CAS  Google Scholar 

  83. Skinhoj P, Conn J, Bradburne AF: Transmission of hepatitis type B from healthy HBs Ag-positive mothers. Br Med 71: 10, 1975

    Google Scholar 

  84. Verco CJ, Hawkins DF: Pregnancy after renal transplantation. Br J Obstet Gynaecol 3: 29, 1982

    Article  Google Scholar 

  85. Lower GD, Stevens LE, Najarian JS, Reemtsma K: Problems from immunosuppressives during pregnancy. Am J Obstet Gynecol 111: 1120, 1971

    PubMed  CAS  Google Scholar 

  86. MacLean AB, Briggs JD, Sharp F, Macpherson SG: Successful triplet pregnancy in renal transplant recipient. Scot Med J X: 320, 1980

    Google Scholar 

  87. Scott JR, Branch DW, Kochenour NK et al.: The effect of repeated pregnancies on renal allograft function. Transplantation 42: 694, 1985

    Article  Google Scholar 

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C. Jacobs C. M. Kjellstrand K. M. Koch J. F. Winchester

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© 1996 Kluwer Academic Publishers

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Wing, A.J., Ehrich, J.H.H. (1996). Pregnancies in Women on Renal Replacement Therapy. In: Jacobs, C., Kjellstrand, C.M., Koch, K.M., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-36947-1_34

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  • DOI: https://doi.org/10.1007/978-0-585-36947-1_34

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