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Quantification And Prescription General Principles

  • Peter Blake
  • John Daugirdas

Abstract

The quantification and prescription of dialysis have received enormous attention in recent years. There has been increasing evidence that higher doses of dialysis are associated with better patient survival and superior clinical outcomes. Measurement of dialytic dose has therefore become almost routine in many centers. It has become apparent, however, that there are many methodological and practical problems associated with both quantification and prescription of both hemodialysis (HD) and peritoneal dialysis (PD). This chapter will review this important subject and related topics in detail

Keywords

Peritoneal Dialysis Continuous Ambulatory Peritoneal Dialysis Residual Renal Function Serum Urea Nitrogen Protein Catabolic Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Johnson WJ, Hagge WW, Wagoner RD, Dinapoli RP, Rosevear JW: Effects of urea loading in patients with faradvanced renal failure. Mayo Clin Proc 47: 21, 1972PubMedGoogle Scholar
  2. 2.
    Merril JP, Legrain M, Hoigne R: Observations on the role of urea in uremia. Ann Intern Med 14: 519, 1953Google Scholar
  3. 3.
    Bergstrom J: Uraemic toxins. This editionGoogle Scholar
  4. 4.
    Owen WF Jr, Lew NL, Liu Y, Lowrie EG, Lazarus JM: The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 329: 1001, 1993PubMedGoogle Scholar
  5. 5.
    Pedrini LA, Zereik S, Rasmy S: Causes, kinetics and clinical implications of post-hemodialysis urea rebound. Kidney Int 34: 817, 1988PubMedGoogle Scholar
  6. 6.
    Ward RA, Shirlow MJ, Hayes JM, Chapman GV, Farrell PC: Protein catabolism during hemodialysis. Am J Clin Nutr 32: 2443, 1979PubMedGoogle Scholar
  7. 7.
    Farrell PC, Hone PW: Dialysis-induced catabolism. Am J Clin Nutr 33: 1417, 1980PubMedGoogle Scholar
  8. 8.
    Lim VS, Bier DM, Flanigan MJ, Sum-Ping ST: The effect of hemodialysis on protein metabolism: A leucine kinetic study. J Clin Invest 91: 2429, 1993PubMedGoogle Scholar
  9. 9.
    Van Stone JC, Daugirdas JT: Physiologic Principles. in Handbook of Dialysis, 2nd Ed, edited by Daugirdas JT, Ing TS, Boston: Little, Brown and Company, 1994, p 13Google Scholar
  10. 10.
    Sherman RA: Recirculation revisited. Semin Dial 4: 221, 1991Google Scholar
  11. 11.
    Schneditz D, Kaufman AM, Polaschegg H, Levin NW, Daugirdas JT: Cardiopulmonary recirculation during hemodialysis. Kidney Int 42: 1450, 1992PubMedGoogle Scholar
  12. 12.
    Shackman R, Chisholm GD, Holden AJ, Pigott RW: Urea distribution in the body after haemodialysis. Br Med J 34: 817, 1962Google Scholar
  13. 13.
    Schindhelm K, Farrell PC: Patient-hemodialyzer interactions. Trans Am Soc Artif Intern Organs 24: 357, 1978PubMedGoogle Scholar
  14. 14.
    Frost TH, Kerr DNS: Kinetics of hemodialysis: A theoretical study of the removal of solutes in chronic renal failure compared to normal health. Kidney Int 12: 41, 1977PubMedGoogle Scholar
  15. 15.
    Heineken FG, Evans MC, Keen ML, Gotch FA: Intercom-partmental fluid shifts in hemodialysis patients. Biotechnol Progr 3: 69, 1987Google Scholar
  16. 16.
    Schneditz D, VanStone JC, Daugirdas JT: A regional blood circulation alternative to in-series two-compartment urea kinetic modeling. ASAIO J 39: M573, 1993PubMedGoogle Scholar
  17. 17.
    Schneditz D, Daugirdas JT: Formal analytical solution to a regional blood flow and diffusion-based urea kinetic model. ASAIO J 1994. In pressGoogle Scholar
  18. 18.
    Depner TA, Cheer A, Vedantham R: Is two-compartment modeling required for high-flux hemodialysis? (Abstract) Am Soc Nephrol 1: 354, 1990Google Scholar
  19. 19.
    Cappello A, Grandi F, Lamberti C, Santoro A: Comparative evaluation of different methods to estimate urea distribution volume and generation rate. Int J Artif Organs 1994. In pressGoogle Scholar
  20. 20.
    Bosticardo GM, Alloatti S: Classical urea kinetic model and direct dialysis quantification agreement. ASAIO J 41: 14798, 1995Google Scholar
  21. 21.
    Tattersall JE, Aldridge C, Greenwood RN, Farrington K. How good is the dialysate collection method for determination of V? (Abstract) Am Soc Nephrol 5: 530, 1994Google Scholar
  22. 22.
    Gotch FA: Kinetic modeling in hemodialysis. in Clinical Dialysis, 2nd Ed, edited by Nissenson AR, Fine RN, Gentile DE, Norwalk, Appleton & Lange, 1990, p 118Google Scholar
  23. 23.
    Tattersall JE, Greenwood RN, Farrington K: Intercom-partmental diffusion and cardiopulmonary recirculation in long and short dialyses. (Abstract) Am Soc Nephrol 1995Google Scholar
  24. 24.
    Spiegel DM, Paker PL, Babcock S, Contiguglia R, Klein M: Hemodialysis urea rebound: the effect of increasing dialysis efficiency. Am J Kidney Dis 25: 26, 1995PubMedGoogle Scholar
  25. 25.
    Smye SW, Evans JHC, Will E, Brocklebank JT: Paediatric haemodialysis: estimation of treatment efficiency in the presence of urea rebound. Clin Phys Physiol Meas 13: 51, 1992PubMedGoogle Scholar
  26. 26.
    Star RA, Hootkins R, Thompson JR, Poole T, Toto RD: Variability and stability of two pool urea mass transfer coefficient. Am Soc Nephrol 3: 395, 1992Google Scholar
  27. 27.
    Tsang HK, Leonard EF, LeFavour GS, Cortell S: Urea dynamics during and immediately after dialysis. ASAIO J 8: 251, 1985Google Scholar
  28. 28.
    Keshaviah P, Hanson G, Abraham P, Collins A: Erythropoietin and cell membrane permeability. (Abstract) Kidney Int 37: 304, 1990Google Scholar
  29. 29.
    Jost CMT, Agarwal R, Khair-El-Din K, Graybum PA, Victor RG, Henrich WL: Effects of cooler temperature dialysate on hemodynamic stability in ‘problem’ dialysis patients. Kidney Int 44: 606, 1993PubMedGoogle Scholar
  30. 30.
    Kaufman AM, Morris AT, Glabman MB et al.: Effect of dialysate cooling on blood pressure and effective dialysate dose. (Abstract) Am Soc Nephrol 5: 317, 1994Google Scholar
  31. 31.
    Yu AW, Ing TS, Zabaneh RI, Daugirdas JT: Effect of cold dialysate temperature on urea kinetics during moderate efficiency dialysis. Kidney Int 48: 237, 1995PubMedGoogle Scholar
  32. 32.
    Yu AW, Ing TS, Ejaz AA, Daugirdas JT: Effect of acetate dialysate on urea kinetics during moderate efficiency dialysis. (Abstract) Am Soc Nephrol 5. 533, 1994Google Scholar
  33. 33.
    Kjellstrand C, Kjellstrand P, Skroder R, Ceiderlof IO, Ericsson F, Jacobson S: Dialysis kinetics using pre-and post-concentrations of BUN are not accurate. Am Soc Nephrol 3: 375, 1992Google Scholar
  34. 34.
    Gotch FA, Sargent JA: A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int 28: 526, 1985PubMedGoogle Scholar
  35. 35.
    Lowrie EG, Laird NM, Parker TF, Sargent JA: Effect of the hemodialysis prescription on patient morbidity. N Engl J Med 305: 1176, 1981PubMedCrossRefGoogle Scholar
  36. 36.
    Sargent JA, Gotch FA: Mathematical modeling of dialysis therapy. Kidney Int 18: S2, 1980Google Scholar
  37. 37.
    Sargent JA: Control of dialysis by a single-pool urea model: the National Cooperative Dialysis Study. Kidney Int 23: S13, 1983Google Scholar
  38. 38.
    Daugirdas JT: Second generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. Am Soc Nephrol 4: 1205, 1993Google Scholar
  39. 39.
    Jindal KK, Manuel A, Goldstein MB: Percent reduction in blood urea concentration during hemodialysis (PRU). Trans Am Soc Artif Intern Organs 33: 286, 1987Google Scholar
  40. 40.
    Basile C, Casino F, Lopez T: Percent reduction in blood urea concentration during dialysis estimates Kt/V in a simple and accurate way. Am J Kidney Dis 15: 40, 1990PubMedGoogle Scholar
  41. 41.
    Garred LJ, McCready W: A theory based, simple formula for Kt/V calculation from pre/post urea. Abstr Am Soc Artif Intern Organs 70, 1992Google Scholar
  42. 42.
    Collins AJ, Ma JZ, Umen A: Urea index (Kt/V) and other predictors of hemodialysis patient survival, Am J Kidney Dis 23: 272, 1994Google Scholar
  43. 43.
    Ahmad S, Cole JJ: Lower morbidity associated with higher Kt/V in stable hemodialysis patients. (Abstract) Am Soc Nephrol 1: 346, 1990Google Scholar
  44. 44.
    Loon NR, Pinevich AJ, Banic S, Anderson C: Improved adequacy of hemodialysis (Kt/V) does not improve nutritional status. (Abstract) Am Soc Nephrol 2: 336, 1991Google Scholar
  45. 45.
    Shen FH, Hsu KT: Lower mortality and morbidity associated with higher Kt/V in hemodialysis patients. (Abstract) Am Soc Nephrol 1: 377, 1990Google Scholar
  46. 46.
    Charra B, Calemard E, Ruffet M et al.: Survival as an index of adequacy of dialysis. Kidney Int 41: 1286, 1992PubMedGoogle Scholar
  47. 47.
    Hakim RM, Breyer J, Ismail N, Schulman G: Effects of dose of dialysis on morbidity and mortality. Am J Kidney Dis 23: 661, 1994PubMedGoogle Scholar
  48. 48.
    Parker TF, Husni L, Huang W, Lew N, Lowrie EG: Survival of hemodialysis patients in the Unites States is improved with a greater quantity of dialysis. Am J Kidney Dis 23: 670, 1994PubMedGoogle Scholar
  49. 49.
    Maeda K: Preliminary Report, Japanese Dialysis Society Registry, 1991Google Scholar
  50. 50.
    Held PJ, Port FK: Relationship between Kt/V and mortality. Am Soc Nephrol 5: 37P, 1994Google Scholar
  51. 51.
    Lysaght MJ, Vonesh EF, Gotch F et al.: The influence of dialysis treatment modality on the decline of remaining renal function. Trans Am Soc Artif Intern Organs 37: 598, 1991Google Scholar
  52. 52.
    Pflederer BJ, Torrey C, Lau AH, Daugirdas JT: Postdialysis urea rebound after ‘long’ session length (3.5-4.5 hour) hemodialysis. (Abstract) Am Soc Nephrol 4: 377, 1993Google Scholar
  53. 53.
    Daugirdas JT, Schneditz D: Overestimation of hemodialysis dose (DKt/V) depends on dialysis efficiency (K/V) by regional blood flow but not by conventional 2-pool UKM. ASAIO J 41: 14719, 1995CrossRefGoogle Scholar
  54. 54.
    Daugirdas JT, Schneditz D: Effect of access and cardiopulmonary recirculation on the modeled urea distribution volume. Am J Kidney Dis 1996. In pressGoogle Scholar
  55. 55.
    Depner TA: Prescribing Hemodialysis: A Guide to Urea Modeling, Dordrecht/Boston/London, Kluwer Academic Publishers, 1990Google Scholar
  56. 56.
    MMHD Study Group, Levin NW, Agodoa LY et al.: Comparisons of Smye algorithm with double pool model solution for estimating e(Kt/V). (Abstract) Am Soc Nephrol 5: 519, 1994Google Scholar
  57. 57.
    Pflederer BJ, Torrey C, Daugirdas JT: Use of the inlet Smye technique in patients with vascular access recirculation. Kidney Int 48: 832, 1995PubMedGoogle Scholar
  58. 58.
    Twardowski Z: Effect of longterm increase in the frequency and/or prolongation of dialysis duration on certain clinical mainfestations and results of laboratory investigations in patients with chronic renal failure. Acta Med Pol 116: 31, 1975Google Scholar
  59. 59.
    Snyder D, Louis BM, Gorfien P, Mordujovich J: Clinical experience with longterm, brief, ‘daily’ haemodialysis. Proc Eur Dial Transplant Assoc, 11: 128, 1975PubMedGoogle Scholar
  60. 60.
    Hombrouckx R, Bogaert AM, Leroy F et al.: Limitations of short dialysis are the indications for ultrashort daily auto dialysis. Trans Am Soc Artif Intern Organs 35: 503, 1989Google Scholar
  61. 61.
    Marichal JF, Brignon P, Faller B: Experience d’hémodialyse quotidienne ultracourte avec abord vasculaire raumatique. A propos de deux cas. Nephrologie 11: 135, 1990PubMedGoogle Scholar
  62. 62.
    Buoncristiani U, Giombini L, Cozzari M, Carobi C, Quintaliani G, Brugnano R: Daily recycled bicarbonate dialysis with polyacrylonitrile. Trans Am Soc Artif Intern Organs 29: 669, 1983PubMedGoogle Scholar
  63. 63.
    Harris CP, Townsend JJ: Dialysis disequilibrium syndrome. West J Med 151: 52, 1989PubMedGoogle Scholar
  64. 64.
    Daugirdas JT: Acute hemodialysis prescription. in Handbook of Dialysis, 2nd Ed, edited by Daugirdas JT, Ing TS, Boston, Little, Brown and Company, 1994, p 78Google Scholar
  65. 65.
    Simpson K, Allison MEM: Dialysis and acute renal failure: Can mortality be improved? (Abstract) Proc Eur Dial Transplant Assoc 160, 1993Google Scholar
  66. 66.
    Malchesky PS, Ellis P, Nosse C, Magnusson M, Lankhorst B, Nakamoto S: Direct quantification of dialysis. Dial Transplant 12: 694, 1983Google Scholar
  67. 67.
    Buur T, Larsson R: Accuracy of hemodialysis urea kinetic modeling. Comparison of different models. Nephron 59: 358, 1991PubMedGoogle Scholar
  68. 68.
    Keshaviah P, Ebben J, Luhring D, Emerson P, Collins A: Clinical evaluation of a new online monitor of dialysis adequacy. Am Soc Nephrol 3: 374, 1992Google Scholar
  69. 69.
    Garred LJ, DiGiuseppe B, Chand W, McCready W, Canaud B: Kt/V and protein catabolic rate determination from serial urea measurement in the dialysate effluent stream. Artif Organs 16: 248, 1992PubMedCrossRefGoogle Scholar
  70. 70.
    Ing TS, Yu AW, Tiwari P et al.: Collection of a spent hemodialysate aliquot the composition of which reflects that of total spent dialysate. Am J Kidney Dis 1995. In pressGoogle Scholar
  71. 71.
    von Albertini B, Garcia-Valdecasas J, Barlee V, Lew SQ, Bosch JP: Solute rebound in highly efficient dialysis: impact on quantification of therapy. (Abstract) Am Soc Nephrol 4: 393, 1993Google Scholar
  72. 72.
    Hume R, Weyers E: Relationship between total body water and surface area in normal and obese subjects. J Clin Pathol 24: 234, 1971PubMedGoogle Scholar
  73. 73.
    Watson PE, Watson ID, Batt RD: Total body water volumes for adult males and females estimated from simple anthopometric measurements. Am J Clin Nutr 33: 27, 1980PubMedGoogle Scholar
  74. 74.
    Daugirdas JT, Depner TE: A nomogram approach to hemodialysis urea modeling. Am J Kidney Dis 23: 33, 1994PubMedGoogle Scholar
  75. 75.
    Daugirdas JT: Chronic hemodialysis prescription, in Handbook of Dialysis, 2nd Ed, edited by Daugirdas JT, Ing TS, Boston, Little, Brown and Company, 1994, p 92Google Scholar
  76. 76.
    Van Stone JC: Hemodialysis apparatus. in Handbook of Dialysis, 2nd Ed, edited by Daugirdas JT, Ing TS, Boston, Little, Brown & Company, 1994, p 32Google Scholar
  77. 77.
    Gotch F: Hemodialysis: Technical and kinetic considerations. in The Kidney, edited by Brenner B, Rector FC Jr, Philadelphia, WB Saunders Co, 1976, p 1972Google Scholar
  78. 78.
    Sargent J, Gotch F: Principles and biophysics of dialysis. in Replacement of Renal Function by Dialysis, 2nd Ed, edited by Drukker W, Parsons F, Maher J, The Hague, Martinus Nijhoff Publishers, 1985, p 53Google Scholar
  79. 79.
    Depner TA, Rizwan S, Stasi TA: Pressure effects on roller pump blood flow during hemodialysis. Trans Am Soc Artif Intern Organs 36: M456, 1990Google Scholar
  80. 80.
    Matzke GR, Rault R, Joy M, Freedv B: Can delivered dialysis Kt/V be accurately predicted from the dialysis prescription? (Abstract) Am Soc Nephrol 5: 522, 1994Google Scholar
  81. 81.
    Taylor AJ, Vadgama P: Analytical reviews in clinical biochemistry: the estimation of urea. Ann Clin Biochem 29: 245, 1992PubMedGoogle Scholar
  82. 82.
    Daugirdas JT, Ing TS, Humayun HM et al.: Two-hour, high-surface-area hemodialysis: a feasibility study. Int J Artif Organs 4: 13, 1981PubMedGoogle Scholar
  83. 83.
    Schiff M, Parker E, Carlson C et al.: Too little, too long: why do patients remain underdialyzed? (Abstract) Am Soc Nephrol 5: 527, 1994Google Scholar
  84. 84.
    Leypoldt JK, Kablitz C, Gregory MC, Senekjian HO, Cheung AK: Prescribing hemodialysis using a weekly urea mass balance model. Biochem Pharmacol 9: 271, 1991CrossRefGoogle Scholar
  85. 85.
    Giovannetti S, Maggiore Q: A low nitrogen diet with proteins of high biological value for severe chronic uremia. Lancet 1: 1000, 1964PubMedGoogle Scholar
  86. 86.
    Lowrie EG, Lew NL: Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis 5: 458, 1990Google Scholar
  87. 87.
    Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfson M, Humphreys MH: Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int 14: 491, 1978PubMedGoogle Scholar
  88. 88.
    Acchiardo SA, Moore LM, Latour PA: Malnutrition as the main factor in morbidity and mortality of hemodialysis patients. Kidney Int 24(Suppl 16): S199, 1983Google Scholar
  89. 89.
    Dumler F, Zasuwa G: Factors influencing protein catabolic rate in chronic maintenance hemodialysis patients. Kidney Int 37: 294, 1990Google Scholar
  90. 90.
    Lowrie EG, Lew NL, Liu Y: The effect of differences in urea reduction ratio (URR) on death risk in hemodialysis patients: a preliminary analysis, Memo to National Medical Care DSD Medical Directors, 1991, November 5: 1Google Scholar
  91. 91.
    Schulman G, Wingard RL, Hutchison RL, Lawrence P, Hakim RM: The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis 21: 527, 1993PubMedGoogle Scholar
  92. 92.
    Held PJ, Port FK, Garcia J, Gaylin DS, Levin NW, Agodoa L: Hemodialysis prescription and delivery in the US: results from USRDS Case Mix Study. (Abstract) Am Soc Nephrol 2: 328, 1991Google Scholar
  93. 93.
    Herrmann FR, Safran C, Levkoff SE, Minaker KL: Serum albumin level on admission as a predictor of death, length of stay, and readmission. Arch Intern Med 152: 125, 1992PubMedGoogle Scholar
  94. 94.
    Murray MJ, Marsh HM, Wochos DN, Moxness KE, Offord KP, Callaway CV: Nutritional assessment of intensive-care unit patients. Mayo Clin Proc 63: 1106, 1988PubMedGoogle Scholar
  95. 95.
    Pollak AJ, Strong RM, Gribbon R, Shah H: Lack of predictive value of the APACHE II score in hypoalbuminemic patients. J Parent Ent Nutr 15: 313, 1991Google Scholar
  96. 96.
    Gentric A, Cledes J: Immediate and long-term prognosis in acute renal failure in the elderly. Nephrol Dial Transplant 6: 86, 1991PubMedGoogle Scholar
  97. 97.
    Lindsay RM, Spanner E: A hypothesis: The protein catabolic rate is dependent upon the type and amount of treatment in dialyzed uremic patients. Am J Kidney Dis 13: 382, 1989PubMedGoogle Scholar
  98. 98.
    Venning MC, Faragher EB, Harty JC et al.: The relationship between Kt/V and nPCR in haemodialysis patients in cross sectional studies is mathematical coupling. (Abstract) Am Soc Nephrol 4: 393, 1993Google Scholar
  99. 99.
    Poignet JL, Chauveau P, Desassis JF, Puget J: Adequacy of hemodialysis and nutrition: evaluation of an online urea monitor. (Abstract) Am Soc Nephrol 5: 525, 1994Google Scholar
  100. 100.
    Mabuchi H, Nakahashi H: Underestimation of serum albumin by the bromcresol purple method and a major endogenous ligand in uremia. Clin Chim Acta 167: 89, 1993Google Scholar
  101. 101.
    Gault MH, Campbell N, Purchase L, Longerich L: Interdialysis weight gain with low predialysis concentrations of proteins and lipids and high end-dialysis values after weight removal. (Abstract) Am Soc Nephrol 4: 347, 1993Google Scholar
  102. 102.
    Depner TA, Cheer AY: Modeling urea kinetics with two vs three BUN measurements: A critical comparison. Trans Am Soc Artif Intern Organs 35: 499, 1989Google Scholar
  103. 103.
    Gotch FA, Keen ML: Care of the patient on hemodialysis. in Introduction to Dialysis, edited by Cogan MG, Garovoy MR, New York, Churchill Livingstone, 1985, p 73Google Scholar
  104. 104.
    Depner TA, Daugirdas JT: Formulas for prediction of normalized protein catabolic rate. J Am Soc Nephrol 1996. In pressGoogle Scholar
  105. 105.
    Daugirdas JT: The post:pre-dialysis plasma urea nitrogen ratio to estimate Kt/V and NPCR: validation. Int J Artif Organs 12: 420, 1989PubMedGoogle Scholar
  106. 106.
    Lindsay RM, Spanner E, Heidenheim P, Liftdsay S, LeFebvre JMJ: The influence of dialysis membrane upon protein catabolic rate. Trans Am Soc Artif Intent Organs 37: M134, 1991Google Scholar
  107. 107.
    Gutierrez A, Alvestrand A, Wahren J, Bergstrom J: Effect of in vivo contact between blood and dialysis membranes on protein catabolism in humans. Kidney Int 38: 487, 1990PubMedGoogle Scholar
  108. 108.
    Gutierrez A, Bergstrom J, Alvestrand A: Protein catabolism in sham-hemodialysis: the effect of different membranes. Clin Nephrol 38: 20, 1992PubMedGoogle Scholar
  109. 109.
    Himmelfarb J: Infection in hemodialysis patients: dodialysis membranes play a role? Semin Dial 5: 108, 1992Google Scholar
  110. 110.
    Schulman G, Fogo A, Gung A, Badr K, Hakim R: Complement activation retards resolution of acute ischemic renal failure in the rat. Kidney Int 40: 1069, 1991PubMedGoogle Scholar
  111. 111.
    Hakim RM, Wingard RL, Lawrence P, Parker RA, Schulman G: Use of biocompatible membranes improves outcome and recovery from acute renal failure. (Abstract) Am Soc Nephrol 3: 367, 1992Google Scholar
  112. 112.
    Seres DS, Strain GW, Hashim SA, Goldberg IJ, Levin NW: Improvement of plasma lipoprotein profiles during high-flux dialysis. Am Soc Nephrol 3: 1409, 1993Google Scholar
  113. 113.
    Josephson MA, Fellner SK, Dasgupta A: Improved lipid profiles in patients undergoing high-flux hemodialysis. Am J Kidney Dis 20: 361, 1992PubMedGoogle Scholar
  114. 114.
    Parthasarathy S, Steinberg D, Witztum JL: The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annu Rev Med 43: 219, 1992PubMedGoogle Scholar
  115. 115.
    Chanard J, Brunois JP, Melin JP, Lavaud S, Toupance O: Long-term results of dialysis therapy with a highly permeable membrane. Artif Organs 6: 261, 1982PubMedCrossRefGoogle Scholar
  116. 116.
    Hornberger JC, Chernew ME, Petersen J, Garberv AM: A multivariate analysis of mortality and hospital admissions with high-flux dialysis. Am Soc Nephrol 3: 1227, 1992Google Scholar
  117. 117.
    Levin NW, Dumler F, Zasuwa G, Stalla K: Mortality comparison between conventional and high flux dialysis. (Abstract) Am Soc Nephrol 1: 365, 1990Google Scholar
  118. 118.
    Levin NW, Zasuwa GA, Dumler F: Effect of membrane type on causes of death in hemodialysis patients. (Abstract) Am Soc Nephrol 2: 335, 1991Google Scholar
  119. 119.
    Pollak VE, Kant S, Pesce A: A recent decrease in the dialysis case fatality rate: Is there an explanation? (Abstract) Am Soc Nephrol 2: 345, 1991Google Scholar
  120. 120.
    DeOreo PB: Analysis of time, nutrition, and Kt/V as risk factors for mortality in dialysis patients. (Abstract) Am Soc Nephrol 2: 321, 1991Google Scholar
  121. 121.
    Martin-Malo A, Castillo D: Adequacy of dialysis: is it really determined by the type of membrane and buffer? (Abstract) Proc Eur Dial Transplant Assoc 147, 1993Google Scholar
  122. 122.
    Hakim RM, Stannard D, Port FK, Held PJ: The effect of the dialysis membrane on mortality of chronic hemodialysis patients. (Abstract) Am Soc Nephrol 5: 451, 1994Google Scholar
  123. 123.
    Hakim RM, Wingard RL, Ikizler TA et al.: Interrelationships of dialyzer biocompatibility with nutritional parameters. (Abstract) Am Soc Nephrol 5: 451, 1994Google Scholar
  124. 124.
    Vanholder RC, DeSmet RV, Ringoir SM: Assessment of urea and other uremic markers for quantification of dialysis efficacy. Clin Chem 38: 1429, 1992PubMedGoogle Scholar
  125. 125.
    Bassingthwaighte JB, Noodleman L, van der Vusse G, Little SE, Glatz JFC, Reneman RS: Albumin-facty-acid-endothelial membrane interactions and fatty acid transport in the heart. Fed Proc 46: 686, 1987Google Scholar
  126. 126.
    Besseghir K, Mosig D, Roch-Ramel F: Facilitation by serum albumin of renal tubular secretion of organic anions. Am J Physiol 256: F475, 1989PubMedGoogle Scholar
  127. 127.
    Gulyassy PF, Depner TA, Shearer GC: Comparison of binding by concentrated peritoneal dialysate and serum. ASAIO J 39: M569, 1993PubMedGoogle Scholar
  128. 128.
    Morachiello P, Ladini S, Fracasso A et al.: Combined hemodialysis-hemoperfusion in the treatment of secondary hyperparathyroidism of uremic patients. Biochem Pharmacol 9: 148, 1991Google Scholar
  129. 129.
    Stange J, Ramlow W, Mitzner S, Schmidt R, Klinkmann H: Dialysis against a recycled albumin solution enalbes the removal of albumin-bound toxins. Artif Organs 17: 809, 1993PubMedCrossRefGoogle Scholar
  130. 130.
    Charra B: Importance of hypertension to survival on long dialysis. Personal communication, 1994Google Scholar
  131. 131.
    Babb AL, Popovich RP, Christopher TC, Scribner BH: The genesis of the middle molecule hypothesis. Trans Am Soc Artif Intern Organs 17: 81, 1971PubMedGoogle Scholar
  132. 132.
    Charra B, Laurent G, Calemard E et al.: Survival in dialysis and blood pressure control. Contrib Nephrol 106: 179, 1994PubMedGoogle Scholar
  133. 133.
    Luik A, Charra B, Katzarski K et al.: Blood pressure control and fluid state in patients on long treatment time dialysis. (Abstract) Am Soc Nephrol 5: 521, 1994Google Scholar
  134. 134.
    vonAlbertini B, Miller JH, Gardner PW, Shinaberger JH: Performance characteristics of high flux haemodiafiltration. Proc Eur Dial Transplant Assoc 21: 447, 1985Google Scholar
  135. 135.
    Velasquez MT, von Albertini B, Lewv SQ, Moore J, Bosch JP: Shorter treatment time with adequate highly efficient hemodialysis is not associated with higher incidence of hypertension in ESRD patients. (Abstract) Am Soc Nephrol 5: 532, 1994Google Scholar
  136. 136.
    Gennari FJ, Rimmer JM: Acid-base disorders in end-stage renal disease. Semin Dial 3: 81, 1990Google Scholar
  137. 137.
    Heineken FG: Brady-Smith M, Haynie J, Van Stone JC: Prescribing dialysate bicarbonate concentrations for hemodialysis patients. Int J Artif Organs 11: 45, 1988PubMedGoogle Scholar
  138. 138.
    Thews O, Hutten H: A comprehensive model of the dynamic exchange processes during hemodialysis. Med Prog Technol 16: 145, 1990PubMedGoogle Scholar
  139. 139.
    Bushinsky DA, Lam BC, Nespeca R, Sessler NE, Grynpas MD: Decreased bone carbonate content in response to metabolic, but not respiratory, acidosis. Am J Physiol 265: F530, 1993PubMedGoogle Scholar
  140. 140.
    Mitch WE, May RC, Maroni BJ, Druml W: Protein and amino acid metabolism in uremia: influence of metabolic acidosis. Kidney Int 27(Suppl): S205, 1989Google Scholar
  141. 141.
    Oettinger CW, Oliver JC: Normalization of uremic acidosis in hemodialysis patients with a high bicarbonate dialysate. Am Soc Nephrol 3: 1804, 1993Google Scholar
  142. 142.
    Schneditz D, Holzer H, Daugirdas JT: A nomogram approach to estimate equilibrated post-dialysis BUN and whole-body (2-pool) Kt/V in hemodialysis. Proc Eur Dial Transplant Assoc-Eur Renal Assoc 213, 1994Google Scholar
  143. 143.
    Foley RJ et al.: Left ventricular hypertrophy in dialysis patients. Semin Dial 5: 34, 1992Google Scholar
  144. 144.
    Zager P, Campbell M, Skipper B et al.: Effect of blood pressure on mortality in hemodialysis patients. (Abstract) Am Soc Nephrol 5: 534, 1994Google Scholar
  145. 145.
    Lowrie EG, Laird NM Cooperative dialysis study. Kidney Int 23: S1, 1983Google Scholar
  146. 146.
    Boen ST, Haagsman-Schouten WAG, Bimie RJ: Long-term peritoneal dialysis and a peritoneal dialysis-index. Dial Transplant 7: 377, 1978Google Scholar
  147. 147.
    Teehan BP, Schleifer CR, Sigler MH, Gilgore GS: A quantitative approach to the CAPD prescription. Perit Dial Bull 5: 152, 1985Google Scholar
  148. 148.
    Blumenkrantz MJ, Kopple HD, Moran JK: Coburn JW: Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis. Kidney Int 21: 849, 1982PubMedGoogle Scholar
  149. 149.
    Lysaght MJ, Pollock CA, Hallet MD, Ibels LS, Farrell PC: The relevance of urea kinetic modeling to CAPD. Trans Am Soc Artif Intern Organs 35: 784, 1989Google Scholar
  150. 150.
    Tattersall JE, Doyle S, Greenwood RN, Farrington K: Kinetic modelling and underdialysis in CAPD patients. Nephrol Dial Transplant 8: 535, 1993PubMedGoogle Scholar
  151. 151.
    Selgas R, Bajo MA, Fernandez-Reyes MJ, Bosque E, Lopez-Revuelta K, Jimenez C, Borrego F, de Alvaro F: An analysis of adequacy of dialysis in a selected population on CAPD for over 3 years: the influence of urea and creatinine kinetics. Nephrol Dial Transplant 8: 1244, 1993PubMedGoogle Scholar
  152. 152.
    Keshaviah PR, Nolph KD, Van Stone JC: The peak concentration hypothesis: a urea kinetic approach to comparing the adequacy of continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis. Perit Dial Int 9: 257, 1989PubMedGoogle Scholar
  153. 153.
    Teehan BP, Schleifer CR, Brown JM, Sigler MH, Raimondo J: Urea kinetic analysis and clinical outcome on CAPD. A five year longitudinal study. Adv Perit Dial 6: 181, 1990PubMedGoogle Scholar
  154. 154.
    Blake PG, Sombolos K, Abraham G, Weissgarten J, Pemberton R, Chu GL, Oreopoulos DG Lack of correlation between urea kinetic indices and clinical outcomes in patients on continuous ambulatory peritoneal dialysis. Kidney Int 39: 700, 1991PubMedGoogle Scholar
  155. 155.
    Brandes JC, Piering WF, Beres JA, Blumenthal SS, Fritsche C: Clinical outcome of continuous ambulatory peritoneal dialysis predicted by urea and creatinine kinetics. Am Soc Nephrol 2: 1430, 1992Google Scholar
  156. 156.
    Keshaviah PR, Nolph KD, Prowant B, Moore H, Ponferrada L, Van Stone J, Twardowski ZJ, Khanna R: Defining adequacy of CAPD with urea kinetics. Adv Perit Dial 6: 173, 1990PubMedGoogle Scholar
  157. 157.
    Goodship THJ, Ward MK, Wilkinson R: Urea kinetic modelling (UKM) and nutritional status in CAPD. Am Soc Nephrol 2: 361, 1991Google Scholar
  158. 158.
    Lameire NH, Vanholder R, Veyt D, Lambert VMC, Ringoir S: A longitudinal, five year survey of urea kinetic parameters in CAPD patients. Kidney Int 42: 426, 1992PubMedGoogle Scholar
  159. 159.
    Blake PG, Balaskas E, Blake R, Oreopoulos DG: Urea kinetics has limited relevance in assessing adequacy of dialysis in CAPD. Adv Perit Dial 8: 65, 1992PubMedGoogle Scholar
  160. 160.
    Soreide R, Dracup B, Svarstad E, Iversen BM: Increased total body fat during PD treatment. Adv Perit Dial 8: 173, 1992PubMedGoogle Scholar
  161. 161.
    Keshaviah PR: Presentation 14th Annual Conference on Peritoneal Dialysis, Orlando, January 1994Google Scholar
  162. 162.
    Schmidt R, Dumler F, Cruz C: Indirect measures of total body water may confound precise assessment of peritoneal dialysis adequacy. Perit Dial Int 13(Suppl 2): S224, 1993Google Scholar
  163. 163.
    Odar-Cederlof I, Ericsson F, Eriksson CG, Kjellstrand CM: Oral antipyrin, a simple, accurate and non-bloody way of measuring total body water in hemodialysis patients. Am Soc Nephrol 2: 342, 1991Google Scholar
  164. 164.
    Dumler F, Schmidt R, Cruz C: Abbreviated method for urea kinetic modeling in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 13(Suppl 2): S50, 1993Google Scholar
  165. 165.
    Burkart JM, Jordan JR, Rocco MV: Assessment of dialysis dose by measured clearance versus extrapolated data. Perit Dial Int 13: 184, 1993PubMedGoogle Scholar
  166. 166.
    Bergstrom J, Furst P, Alvestrand A, Lindholm B: Protein and energy intake, nitrogen balance and nitrogen losses in patients treated with continuous ambulatory peritoneal dialysis. Kidney Int 44: 1048, 1993PubMedGoogle Scholar
  167. 167.
    Randerson DH, Chapman GV, Farrell PC: Amino acid and dietary status in long-term CAPD patients. in Peritoneal Dialysis, edited by Atkins RC, Farrell PC, Thomson N, Edinburgh, Churchill-Livingstone, 1981, p 171Google Scholar
  168. 168.
    Borah MH, Schoenfeld PY, Gotch FA, Sargent JA, Wolson M, Humphreys MH: Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int 14: 491, 1978PubMedGoogle Scholar
  169. 169.
    Kjeldahl J: Neue Methode zur Bestimmung des Stick-stoffs in organischen Körpers. Z Analyt Chem 22: 366, 1883Google Scholar
  170. 170.
    Keshaviah PR, Nolph KD: Protein catabolic rate calculations in CAPD patients. Trans Am Soc Artif Intern Organs 37: M400, 1991Google Scholar
  171. 171.
    Harty JC, Boulton H, Curwell J, Heelis N, Uttley L, Venning MC, Gokal R: The normalized protein catabolic rate is a flawed marker of nutrition in CAPD patients. Kidney Int 45: 103, 1994PubMedGoogle Scholar
  172. 172.
    Burton PR, Walls J: Selection-adjusted comparison of life expectancy of patients on continuous ambulatory peritoneal dialysis, haemodialysis and renal transplantation. Lancet 1: 1115, 1997Google Scholar
  173. 173.
    Posen G, Arbus G, Hutchinson T, Jeffery J: Survival comparison of adult non diabetic patients treated with either hemodialysis or CAPD for end-stage renal failure. Perit Dial Bull 7: 78, 1987Google Scholar
  174. 174.
    Maiorca R, Cancarini G, Manili L, Camerini C, Brunori G: Life table analysis of patient and method survival in continuous ambulatory peritoneal dialysis and hemodialysis after six years’ experience, in Advances in CAPD, edited by Khanna R, Nolph KD, Prowant B et al., Toronto, University of Toronto Press, 1986, p 27Google Scholar
  175. 175.
    US Renal Data System: USRDS 1991 Annual Data Report, The National Institute of Health, National Institures of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 1991Google Scholar
  176. 176.
    Lunde NM, Port FK, Wolfe RA, Guire KE: Comparison of mortality risk by choice of CAPD versus hemodialysis among elderly patients. Adv Perit Dial 7: 68, 1991PubMedGoogle Scholar
  177. 177.
    Nelson CB, Port FK: Dialysis patient survival: evaluation of CAPD vs HD using 3 techniques. Perit Dial Int (Suppl 1): 144, 1992Google Scholar
  178. 178.
    Depner TA: Quantifying hemodialysis and peritoneal dialysis: examination of the Peak Concentration Hypothesis. Semin Dial 7: 315, 1994Google Scholar
  179. 179.
    Rottembourg J, Issad B, Gallego JL et al.: Evolution of residual renal functions in patients undergoing maintenance hemodialysis or continuous ambulatory’ peritoneal dialysis. Proc Eur Dial Transplant Assoc 19: 397, 1982Google Scholar
  180. 180.
    Cancarini GC, Brunori G, Camerini C, Brasa S, Manili L, Maiorca R: Renal function recovery and maintenance of residual diuresis in CAPD and hemodialysis. Perit Dial Bull 6: 76, 1986Google Scholar
  181. 181.
    Ballardie F, Kerr D, Tennent G et al.: Haemodialysis versus CAPD: equal predisposition to amyloidosis? Lancet 1: 793, 1986Google Scholar
  182. 182.
    Keshaviah P: Urea kinetic and middle molecule approaches to assessing the adequacy of hemodialysis and CAPD. Kidney Int 43(Suppl 40): S28, 1993Google Scholar
  183. 183.
    Mitch WE, Jurkovita C, England BK: Mechanisms that cause protein and amino acid metabolism in uremia. Am J Kidney Dis 91, 1993Google Scholar
  184. 184.
    Hakim RM: Clinical implications of hemodialysis membrane biocompatibility. Kidney Int 44: 484, 1993PubMedGoogle Scholar
  185. 185.
    Lindholm B, Bergstrom J: Nutritional aspects of peritoneal dialysis. Kidney Int 42(Suppl 38): S165, 1992Google Scholar
  186. 186.
    Blake PG: Problems predicting continuous ambulatory peritoneal dialysis outcomes with small solute clearances. Perit Dial Int 13(Suppl 2): S209, 1993Google Scholar
  187. 187.
    Teehan BP, Schleifer CR, Brown J: Urea kinetic modeling is an appropriate assessment of adequacy. Semin Dial 5: 189, 1992Google Scholar
  188. 188.
    Goodship THJ, Passlick-Deetjen J, Ward MK, Wilkinson R: Adequacy of dialysis and nutritional status in CAPD. Nephrol Dial Transplant 8: 1366, 1993PubMedGoogle Scholar
  189. 189.
    Churchill DN, Thorpe K, Taylor DW, Keshaviah P: Adequacy of peritoneal dialysis. Am Soc Nephrol 5: 439, 1994Google Scholar
  190. 190.
    Cruz C, Dumler F, Schmidt R, Gotch F: Enhanced peritoneal dialysis delivery with PD-Plus™. Adv Perit Dial 8: 288, 1992PubMedGoogle Scholar
  191. 191.
    Keen M, Lipps B, Gotch F: The measured creatinine generation rate in CAPD suggests only 78% of prescribed dialysis is delivered. Adv Perit Dial 9: 73, 1993PubMedGoogle Scholar
  192. 192.
    Warren PJ, Brandes JC: Compliance with the peritoneal dialysis prescription is poor. Am Soc Nephrol 4: 1627, 1994Google Scholar
  193. 193.
    Bergstrom J, Alvestrand A, Lindholm B, Tranacus A: Relationship between KT/V and protein catabolic rate is different in continuous peritoneal dialysis and haemodialysis patients. Am Soc Nephrol 2: 358, 1991Google Scholar
  194. 194.
    Harty JC, Farragher B, Boulton H et al.: Is the correlation between the normalised protein catabolic rate (NPCR) and Kt/V the result of mathematical coupling? Am Soc Nephrol 4: 407, 1993Google Scholar
  195. 195.
    Gotch FA: Dependence of normalized protein catabolic rate on Kt/V in continuous ambulatory peritoneal dialysis: not a mathematical artifact. Perit Dial Int 13: 173, 1993PubMedGoogle Scholar
  196. 196.
    Stein A, Walls J: The correlation between Kt/V and protein catabolic rate — a self-fulfilling prophecy. Nephrol Dial Transplant 9: 743, 1994PubMedGoogle Scholar
  197. 197.
    Blake PG: Dependence of normalized protein catabolic rate on Kt/V in CAPD: not a mathematical artifact. Perit Dial Int 14: 405, 1994PubMedGoogle Scholar
  198. 198.
    Lindsay RM, Spanner E, Heidenheim P, Kortas C, Blake PG: PCR, Kt/V and membrane. Kidney Int 43(Suppl 1): S268, 1993Google Scholar
  199. 199.
    Blake PG, Lindsay RM, Spanner E, Heidenheim P, Baird J, Allison M, Oreopoulos DG: Factors modifying the relationship between Kt/V urea and normalized protein catabolic rate (PCRN) in CAPD. Am Soc Nephrol 4: 398, 1993Google Scholar
  200. 200.
    Ronco C, Conz P, Agostini F, Bosch JP, Lew SQ, La Greca G: The concept of adequacy in peritoneal dialysis. Perit Dial Int 14: S93, 1994Google Scholar
  201. 201.
    Twardowski ZJ, Nolph KD: Peritoneal dialysis: how much is enough? Semin Dial 1: 75, 1988Google Scholar
  202. 202.
    Twardowski ZJ, Nolph KD, Khanna R et al.: Peritoneal equilibration test. Perit Dial Bull 7: 138, 1987Google Scholar
  203. 203.
    Blake PG, Balaskas EV, Izatt S, Oreopoulos DG: Is total creatinine clearance a good predictor of clinical outcomes in continuous ambulatory peritoneal dialysis? Perit Dial Int 12: 353, 1992PubMedGoogle Scholar
  204. 204.
    Larpent L, Verger C: The need for using an enzymatic colorimetric assay in creatinine determination of peritoneal dialysis solutions. Perit Dial Int 10: 89, 1990PubMedGoogle Scholar
  205. 205.
    Nolph KD, Moore HL, Twardowski ZJ et al.: Cross-sectional assessment of weekly urea and creatinine clearances in patients on continuous ambulatory peritoneal dialysis. Trans Am Soc Artif Intern Organs 38: M139, 1992Google Scholar
  206. 206.
    du Bois D, du Bois EF: A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17: 863, 1916Google Scholar
  207. 207.
    Keshaviah PR, Nolph KD, Moore HL, Prowant B, Emerson PF, Meyer M, Twardowski ZJ, Khanna R, Ponferrada L, Collins A: Lean body mass estimation by creatinine kinetics. Am Soc Nephrol 4: 1475, 1994Google Scholar
  208. 208.
    Mitch WE, Collier VU, Walser M: Creatinine metabolism in chronic renal failure. Clin Sci 58: 327, 1980PubMedGoogle Scholar
  209. 209.
    Brandes JC, Piering WF, Beres JA: A method to assess efficacy of CAPD: preliminary results. Adv Perit Dial 6: 192, 1990PubMedGoogle Scholar
  210. 210.
    Rocco MV, Burkart JM: The efficacy number as a predictor of morbidity and mortality in peritoneal dialysis patients. Am Soc Nephrol 4: 1184, 1993Google Scholar
  211. 211.
    Nolph KD, Twardowski ZJ, Keshaviah PR: Weekly clearances of urea and creatinine on CAPD and NIPD. Perit Dial Int 12: 298, 1992PubMedGoogle Scholar
  212. 212.
    Holley JL, Piraino B: Careful patient selection and dialysis prescription are required for effective nightly intermittent peritoneal dialysis. Perit Dial Int 14: 155, 1994PubMedGoogle Scholar
  213. 213.
    Piraino B, Bender F, Bernardini J: A comparison of clearances on tidal peritoneal dialysis and intermittent peritoneal dialysis. Perit Dial Int 24: 145, 1994Google Scholar
  214. 214.
    Balaskas E, Izatt S, Chu M, Oreopoulos DG: Tidal volume peritoneal dialysis (TVPD) versus intermittent peritoneal dialysis. Perit Dial Int 3(Suppl): S65, 1993Google Scholar
  215. 215.
    Verger C, Larpent L, Dumontet M: Prognostic values of peritoneal equilibration curves in CAPD patients, in Frontiers in Peritoneal Dialysis, edited by Maher JF, Winchester JF, New York, Field, Rich and Assoc Inc, 1986, p 88Google Scholar
  216. 216.
    Heimburger O, Waniewski J, Werynski A, Sun Park M, Lindholm B: Dialysate to plasma solute concentration (D/P) versus peritoneal transport parameters in CAPD. Nephrol Dial Transplant 9: 47, 1994PubMedGoogle Scholar
  217. 217.
    Blake PG, Flowerdew G, Blake RM, Oreopoulos DG: Serum albumin in patients on continuous ambulatory peritoneal dialysis — predictors and correlations with outcomes. Am Soc Nephrol 3: 1501, 1993Google Scholar
  218. 218.
    Nolph KD, Moore HL, Prowant B, Twardowski ZJ, Khanna R, Camboa S, Keshaviah P: Continuous ambulatory peritoneal dialysis with a high flux membrane. ASAIO J 39: 904, 1993PubMedGoogle Scholar
  219. 219.
    Blake PG, Sombolos K, Izatt S, Oreopoulos DG: A highly permeable membrane is an adverse risk factor in CAPD. Clin Invest Med 14(Suppl): 792, 1991Google Scholar
  220. 220.
    Blake PG, Abraham G, Sombolos K, Izatt S, Weissgarten J, Ayiomamitis A, Oreopoulos DG: Changes in peritoneal membrane transport rates in patients on long term CAPD. Adv Perit Dial 5: 3, 1989PubMedGoogle Scholar
  221. 221.
    Passlick-Deetjen J, Chlebowski H, Koch M, Grabensee B: Changes of peritoneal membrane function during long-term CAPD. Adv Perit Dial 6: 35, 1990PubMedGoogle Scholar
  222. 222.
    Lo W-K, Brendolan A, Prowant BF, Moore HL, Khanna R, Twardowski ZJ, Nolph KD: Changes in the peritoneal equilibration test in selected chronic peritoneal dialysis patients. Am Soc Nephrol 4: 1466, 1994Google Scholar
  223. 223.
    Rocco JR, Burkart JM: Changes in peritoneal tansport during the first month of peritoneal dialysis. Perit Dial Int 13: S77, 1993Google Scholar
  224. 224.
    Gotch F, Schoenfeld P, Gentile D: The peritoneal equilibration test is not a realistic measure of peritoneal clearance. Am Soc Nephrol 3: 361, 1992Google Scholar
  225. 225.
    Lindsay RM, Spanner E: The lower serum albumin does reflect nutritional status. Semin Dial 5: 215, 1992Google Scholar
  226. 226.
    Heimburger O, Bergstrom J, Lindholm B: Is serum albumin an index of nutritional status in continuous ambulatory peritoneal dialysis patients? Perit Dial Int 14: 108, 1994PubMedGoogle Scholar
  227. 227.
    Young GA, Kopple J, Lindholm B et al.: Nutritional assessment of CAPD patients: an international study. Am J Kidney Dis 17: 462, 1991PubMedGoogle Scholar
  228. 228.
    Fenton SA, Johnston N, Delmore T et al.: Nutritional assessment of continuous ambulatory peritoneal dialysis patients. Trans Am Soc Artif Intern Organs XXXIII: 650, 1987Google Scholar
  229. 229.
    Oreopoulos DG, Crassweller P, Katirtzoglou A et al.: Amino acids as an osmotic agent in CAPD. in Continuous Ambulatory Peritoneal Dialysis, edited by Legrain M, Amsterdam, Excerpta medica, 1979, p 335Google Scholar
  230. 230.
    Jones MR, Martis L, Algrim CE et al.: Amino acid solutions for CAPD; rationale and clinical experience. Miner Electrolyte Metab 18: 309, 1992PubMedGoogle Scholar
  231. 231.
    Bruno M, Bagnis C, Marangella M et al.: CAPD with an amino acid dialysis solution: a long-term, cross-over study. Kidney Int 35: 1189, 1989PubMedGoogle Scholar
  232. 232.
    Dombros NV, Prutis K, Tong M et al.: Six-month overnight intraperitoneal amino-acid infusion in continuous ambulatory peritoneal dialysis (CAPD) patients — no effect on nutritional status. Perit Dial Int 10: 79, 1990PubMedGoogle Scholar
  233. 233.
    Kalil R, Jones MR, Martis L, Blake P, Anderson H, Oreopoulos DG: Modification of amino acid peritoneal dialysis fluid to decrease risk of acidosis. Perit Dial Int 14: S14, 1994Google Scholar
  234. 234.
    Ikizler TA, Wingard RL, Breyer JA et al.: Short-term effects of recombinant human growth hormone in CAPD patients. Kidney Int 46: 1178, 1994PubMedGoogle Scholar
  235. 235.
    Kang DH, Lee SW, Kang SW et al.: Recombinant human growth hormone improved nutritional status of under-nourished adult CAPD patients. Am Soc Nephrol 5: 494, 1994Google Scholar
  236. 236.
    Kopple JD: The rationale for the use of growth hormone or insulin-like growth factor I in adult patients with renal failure. Miner Electrolyte Metab 18: 269, 1992PubMedGoogle Scholar
  237. 237.
    Blake PG: Growth hormone and malnutrition in dialysis patients. Perit Dial Int 15: 210, 1995PubMedGoogle Scholar
  238. 238.
    Fine RN: Stimulating growth in uremic children. Kidney Int 42: 188, 1992PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Peter Blake
    • 1
  • John Daugirdas
    • 2
  1. 1.Victoria Hospital Corp.University of Western OntarioLondonCanada
  2. 2.Department of Research (151) Westside VA Medical CenterUniversity of Illinois at ChicagoChicagoUSA

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