Ultrafiltration/Hemofiltration Practice

  • Eduard A. Quellhorst


The first device to perform ultrafiltration in vivo was described by Brull in France (1) and Geiger (2) in Jerusalem using collodium membranes. They observed an undiminished concentration of chlorides, dextrose and non-protein nitrogen in the filtrate whereas phosphorus and calcium were partially retained. The first ultrafiltration with the aim to prolong the life of uremic animals was achieved by Malinow and Korzon in 1947 (3). Using cellophane tubes a filtrate flow of 15–20 ml/min could be obtained at a trans-membrane pressure of 500 mm Hg. Since they substituted the blood filtrate of test animals by injecting Ringer-Krebs-solution and since they made use of the arteriovenous pressure difference as the driving force for the filtration these investigators performed the first ’spontaneous arteriovenous hemofiltration’. A dialyzer-filter design with membrane support systems enabling a rapid fluid removal by ultrafiltration was described by Alwall in 1963 (4), but his first aim was to remove water and not to treat uremia


Diabetic Nephropathy Mean Arterial Blood Pressure Continuous Ambulatory Peritoneal Dialysis TRANSMEMBRANE Pressure Fluid Removal 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Eduard A. Quellhorst
    • 1
  1. 1.Nephrology Center NiedersachsenHannover-MundenGermany

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