Cultured Cardiomyocytes

  • F. W. Smart
  • W. Claycomb
  • J. Delcarpio
  • C. Van Meter


The shortage of donor organs for cardiac transplantation continues to fuel the search for alternatives to the transplantation of human heart allografts[1],[2]. To alleviate this profound cardiac donor shortage, attention has recently focused on the use of biological and mechanical assist devices for permanent implantation[3],[5] and xenogeneic whole organ transplants. Therapies to repair damaged hearts are also gaining acceptance, such as high-risk coronary bypass grafting and transmyocardial laser revascularization[6],[7] Cell transplantation is one method of augmenting these repair processes.


Satellite Cell Cardiac Muscle Cell Cultured CARDIOMYOCYTES Xenogeneic Cell Transmyocardial Laser Revascularization 
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  1. 1.
    First MR. Transplantation in the nineties. Transplantation. 1992;53:1.PubMedCrossRefGoogle Scholar
  2. 2.
    Mudge GH, Goldstein S, Addonizio LJ et al. Task force 3: recipient guidelines/prioritization. J Am Coll Cardiol. 1993;2:1.Google Scholar
  3. 3.
    Magovern JA, Magovern GJ Jr, Magovern GJ, Palumbi MA, Orie JE. Surgical therapy for congestive heart failure: indications for transplantation versus cardiomyoplasty. J Heart Lung Transplant. 1992;11:538.PubMedGoogle Scholar
  4. 4.
    Hooper TL, Stephenson LW. Cardiomyoplasty for end-stage heart failure. Surg Annu. 1993;1:157.Google Scholar
  5. 5.
    Pac WE Jr. Ventricular assist devices and total artificial hearts: a combined registry experience. Ann Thorac Surg. 1993;55:295.CrossRefGoogle Scholar
  6. 6.
    Magovern JA, Magovern GJ Sr, Maher TD Jr et al. Operation for congestive heart failure: transplantation, coronary artery bypass, and cardiomyoplasty. Ann Thorac Surg. 1993;56:418.PubMedCrossRefGoogle Scholar
  7. 7.
    Horvath KA, Smith WJ, Laurence RG et al. Recovery and viability of an acute myocardial infarct after transmyocardial laser revascularization. J Am Coll Cardiol. 1995;25:258.PubMedCrossRefGoogle Scholar
  8. 8.
    Kiortsis V, Koussoulakos S, Wallace H, editors. Recent trends in regeneration research. New York: Plenum Press; 1989.Google Scholar
  9. 9.
    Rumyantsev PP. editor Growth and hyperplasia of cardiac muscle cells. New York: Academic Press; 1991.Google Scholar
  10. 10.
    Lee KF, Wechsler AS. Dynamic cardiomyoplasty. In: Karp RB, Laks H, Wechsler AS, editors. Advances in cardiac surgery. St Louis: Mosby; 1993;4:207.Google Scholar
  11. 11.
    Carpentier A, Chachques JC, Acar C et al. Dynamic cardiomyoplasty at seven years. J Thorac Cardiovasc Surg. 1993;106:42.PubMedGoogle Scholar
  12. 12.
    Niinami H, Pochettino A, Stephenson LW. Use of skeletal muscle grafts for cardiac assist. Trends Cardiovasc Med. 1991;1:122.CrossRefGoogle Scholar
  13. 13.
    Mauro A. Satellite cell of skeletal muscle libers. J Biophys Biochem Cytol. 1961;9:493.PubMedCrossRefGoogle Scholar
  14. 14.
    Zibaitis A, Greentree D, Ma F et al. Myocardial regeneration with satellite cell implantation. Transplant Proc. 1994;26:3294.PubMedGoogle Scholar
  15. 15.
    Soonpaa MH, Koh GY, Klug MG, Field LJ. Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science. 1994;264:98.PubMedCrossRefGoogle Scholar
  16. 16.
    Kao RL, Magovern JA, Tong JY, Magovern GJ. Muscle regeneration of injured myocardium. J Cell Biochem. 1991;45(Suppl.15C):73 (abstract).Google Scholar
  17. 17.
    Field LJ. Atrial natriuretic factor-SV40 antigen transgenes produce tumors and cardiac arrhythmias in mice. Science. 1986;239:1029.CrossRefGoogle Scholar
  18. 18.
    Koe GY, Klug MG, Soonpaa MH, Field LJ. Long-term survival of C2C12 myoblast grafts in heart. J Clin Invest. 1993;92:1548.CrossRefGoogle Scholar
  19. 19.
    Delcarpio JB, Barbee RW, Perry BD, Claycomb WC. Cardiomyocyte transfer into the mammalian heart. In: Claycomb WC, Dinardo P, eds. Cardiac growth and regeneration. New York: NY Acad Sci. 1995;752:267.Google Scholar
  20. 20.
    Claycomb WC, Palazzo MC. Culture of the terminally differentiated adult cardiac muscle cell: a light and scanning electron microscope study. Dev Biol. 1980;161:249.Google Scholar
  21. 21.
    Claycomb WC, Lanson NA Jr. Isolation and culture of the terminally differentiated adult cardiac muscle cell. In Vitro. 1984;20:647.PubMedCrossRefGoogle Scholar
  22. 22.
    Delcarpio JB, Claycomb WC, Moses RL. An ultrastructural morphometric analysis of cultured neonatal and adult rat ventricular cardiac myocytes. Am J Anat. 1989;186:235.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • F. W. Smart
  • W. Claycomb
  • J. Delcarpio
  • C. Van Meter

There are no affiliations available

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