Xenotransplantation of the Lung
Lung and heart-lung transplantation are now established as therapeutic interventions for many terminal conditions affecting the pulmonary system. Paradoxically, our increasing clinical success exacerbates the donor organ shortage by broadening indications for transplantation and increasing referrals of appropriate patients at an earlier stage in their disease. The most acute need is among patients with either congenital heart disease or cystic fibrosis, for whom heart-lung or double lung transplantation is at present the only viable option. Appropriate organs are often not available for this group of generally young patients; many of those listed for transplant die waiting. Additional patients with other end-stage pulmonary disorders might benefit if more lungs were available.
KeywordsComplement Activation Capillary Leak Hyperacute Rejection High Pulmonary Vascular Resistance Cobra Venom Factor
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